Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C76H52O46.C27H39NO3 |
Molecular Weight | 2126.8019 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 15 / 15 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12C[C@H](C)CN[C@@]1([H])[C@@H](C)[C@@]3(CC[C@]4([H])C(C(=O)[C@@]5([H])[C@@]4([H])CC=C6C[C@@H](O)CC[C@]56C)=C3C)O2.OC7=CC(=CC(O)=C7O)C(=O)OC8=CC(=CC(O)=C8O)C(=O)OC[C@H]9O[C@@H](OC(=O)C%10=CC(O)=C(O)C(OC(=O)C%11=CC(O)=C(O)C(O)=C%11)=C%10)[C@H](OC(=O)C%12=CC(O)=C(O)C(OC(=O)C%13=CC(O)=C(O)C(O)=C%13)=C%12)[C@@H](OC(=O)C%14=CC(O)=C(O)C(OC(=O)C%15=CC(O)=C(O)C(O)=C%15)=C%14)[C@@H]9OC(=O)C%16=CC(O)=C(O)C(OC(=O)C%17=CC(O)=C(O)C(O)=C%17)=C%16
InChI
InChIKey=ILZNSORIOPBINX-BMBUXRDQSA-N
InChI=1S/C76H52O46.C27H39NO3/c77-32-1-22(2-33(78)53(32)92)67(103)113-47-16-27(11-42(87)58(47)97)66(102)112-21-52-63(119-72(108)28-12-43(88)59(98)48(17-28)114-68(104)23-3-34(79)54(93)35(80)4-23)64(120-73(109)29-13-44(89)60(99)49(18-29)115-69(105)24-5-36(81)55(94)37(82)6-24)65(121-74(110)30-14-45(90)61(100)50(19-30)116-70(106)25-7-38(83)56(95)39(84)8-25)76(118-52)122-75(111)31-15-46(91)62(101)51(20-31)117-71(107)26-9-40(85)57(96)41(86)10-26;1-14-11-21-24(28-13-14)16(3)27(31-21)10-8-19-20-6-5-17-12-18(29)7-9-26(17,4)23(20)25(30)22(19)15(27)2/h1-20,52,63-65,76-101H,21H2;5,14,16,18-21,23-24,28-29H,6-13H2,1-4H3/t52-,63-,64+,65-,76+;14-,16+,18-,19-,20-,21+,23+,24-,26-,27-/m10/s1
Molecular Formula | C27H39NO3 |
Molecular Weight | 425.6035 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 10 / 10 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Molecular Formula | C76H52O46 |
Molecular Weight | 1701.1985 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 5 / 5 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/15137822Curator's Comment: description was created based on several sources, including:
https://en.wikipedia.org/wiki/Jervine | https://www.google.com/patents/US20150259313
Sources: https://www.ncbi.nlm.nih.gov/pubmed/15137822
Curator's Comment: description was created based on several sources, including:
https://en.wikipedia.org/wiki/Jervine | https://www.google.com/patents/US20150259313
Jervine (11-Ketocyclopamine) is a naturally occuring steroidal alkaloid is derived from the Veratrum plant species. Jervine is a teratogen implicated in birth defects when consumed by animals during a certain period of their gestation. Over the Hedgehog signaling pathway Jervine effectively inhibit the tumor growth using three human tumor xenograft models including lung cancer, pancreatic cancer and basal cell carcinoma. Jervine has the potential to advance to a treatment for different tumors.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: map04340 Sources: https://www.ncbi.nlm.nih.gov/pubmed/12606278 |
50.0 nM [IC50] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Unknown Approved UseUnknown |
PubMed
Title | Date | PubMed |
---|---|---|
Roughing up Smoothened: chemical modulators of hedgehog signaling. | 2002 Nov 6 |
|
Development of an enzyme-linked immunosorbent assay for the veratrum plant teratogens: cyclopamine and jervine. | 2003 Jan 29 |
|
Sonic hedgehog exerts distinct, stage-specific effects on tongue and taste papilla development. | 2004 Dec 15 |
|
Glycoalkaloids and metabolites inhibit the growth of human colon (HT29) and liver (HepG2) cancer cells. | 2004 May 19 |
|
Factors that regulate embryonic gustatory development. | 2007 Sep 18 |
|
Antitumor activity of extracts and compounds from the rhizomes of Veratrum dahuricum. | 2008 Aug |
|
[Determination of jervine and veratramine in Veratrum plants using high performance liquid chromatography coupled with evaporative light scattering detection]. | 2008 Jan |
|
Isolation, purification, and full NMR assignments of cyclopamine from Veratrum californicum. | 2008 Jun 24 |
|
Accidental intoxication with Veratrum album. | 2008 Nov-Dec |
|
Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium. | 2009 |
|
Synthesis of all diastereomers of the piperidine--alkaloid substructure of cyclopamine. | 2009 Dec 3 |
|
Ingestion of false hellebore plants can cross-react with a digoxin clinical chemistry assay. | 2010 Jun |
|
Antitumor and antiplatelet activity of alkaloids from veratrum dahuricum. | 2010 Jun |
|
Hedgehog signaling is required at multiple stages of zebrafish tooth development. | 2010 Nov 30 |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://www.google.com/patents/US20150259313
Oral: 40 or 60 or 80 mg/kg once every day (during 21 days).
Intravenous: 20 or 40 or 80 mg/kg once every day (during 21 days).
Route of Administration:
Other
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/12606278
Tongues treated with jervine at 10 μM exhibited a dorsal anterior tongue that was almost completely occupied by fungiform papillae.
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 01:03:34 GMT 2023
by
admin
on
Sat Dec 16 01:03:34 GMT 2023
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Record UNII |
4L3IA7D34B
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Record Status |
Validated (UNII)
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Record Version |
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