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Restrict the search for
beta carotene
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Class (Stereo):
CHEMICAL (RACEMIC)
Vindeburnol, a derivative of the plant alkaloid vincamine that that bears neuroprotective properties. Animal model for Alzheimer's disease has shown that vindeburnol reduced neuroinflammation and amyloid burden. In addition, the treatment with this drug can be of benefit in multiple sclerosis patients.
Status:
Investigational
Source:
INN:bedoradrine [INN]
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Bedoradrine (also known as KUR-1246 or MN-221), an ultra selective beta 2-adrenoceptor agonist, that participated in phase II clinical trials as an adjunct to standard therapy in the management of patients with acute exacerbation of asthma who did not respond to standard therapy. In addition, the drug was involved in trials for the treatment of preterm labor in obstetrical practice. Bedoradrine is also was studied in phase I of clinical trials for its use for treating chronic obstructive pulmonary disease, however, the efficacy for this disease was uncertain.
Class (Stereo):
CHEMICAL (RACEMIC)
Ridazolol is a cardioselective and vasodilating beta-adrenergic receptor antagonist. It also has moderate alpha-adrenolytic activity (the presence of a heterogeneous population of postjunctional alpha adrenoceptors has been suggested). Ridazolol was investigated for use in arrhythmias and ischaemic heart disorders. In patients with confirmed coronary artery disease and reproducible ST-segment depression, blood pressure and heart rate under exercise were significantly reduced for 5 hours, and improvement of ST-segment depression lasted 1 hour. Ridazolol is well tolerated. This drug is not currently used.
Class (Stereo):
CHEMICAL (MIXED)
Cicloxolone is a broad spectrum antiviral agent with a largely non-specific and complex mode of antiviral action. The drug was active during all stages of the virus replication cycle, indicating that it does not operate by the specific inhibition of any single essential virus gene product. The drug reduced the number of vesicular stomatitis virusparticles assembled and released by 100- to 1000-fold. Infectious virus yield was reduced 1000- to 10000-fold, giving a 10-fold or greater increase in the particle/p.f.u. ratio. The reduced number of virus particles produced in the presence of Cicloxolone results from two superimposed effects: suppression of vesicular stomatitis virussecondary transcription and viral protein synthesis, and perturbation of virion assembly.
Status:
Investigational
Class (Stereo):
CHEMICAL (RACEMIC)
Betaprodine is an opioid analgesic under international control according to the UN Single Convention 1961. It has been used in obstetrics, as pre-operative medication, for minor surgical procedures.
Class (Stereo):
CHEMICAL (RACEMIC)
Nafetolol (K5407) is a beta-blocking agent.
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Vatalanib a potent oral tyrosine kinase inhibitor with a selective range of molecular targets, has been extensively investigated and has shown promising results in patients with solid tumors in early trials. Vatalanib selectively inhibits the tyrosine kinase domains of vascular endothelial growth factor (VEGF) receptor tyrosine kinases (important enzymes in the formation of new blood vessels that contribute to tumor growth and metastasis), platelet-derived growth factor (PDGF) receptor, and c-KIT. The adverse effects of vatalanib appear similar to those of other VEGF inhibitors. In the CONFIRM trials, the most common side effects were high blood pressure, gastrointestinal upset (diarrhea, nausea, and vomiting), fatigue, and dizziness.
Class (Stereo):
CHEMICAL (RACEMIC)
Indopanolol is indole derivative patented by German pharmaceutical company Sandoz-Patent-G.m.b.H. as α- and β-adrenergic receptor blocking agent.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Ciprostene is a synthetic, chemically stable analog of prostacyclin (PGI2). In animal models, administration of ciprostene resulted in dose-dependent hypotension, tachycardia, and inhibition of ex vivo ADP-induced platelet aggregation. Ciprostene was evaluated in clinical trials in patients with peripheral vascular disease. It was found to reduce restenosis in patients with coronary artery disease undergoing therapeutic percutaneous transluminal coronary angioplasty.
Class (Stereo):
CHEMICAL (EPIMERIC)
Cloxestradiol is a chlorinated derivative of estradiol, invented by Danish company Leo Pharma AS in 1963. The compound is claimed to have estrogenic activity, as was demonstrated by the extended duration of oestrus caused by the injection of cloxestradiol to castrated female rats.
