U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Showing 1 - 10 of 11 results

Status:
US Approved Rx (2011)
First approved in 2003

Class (Stereo):
CHEMICAL (RACEMIC)



Epinastine (brand names Alesion, Elestat, Purivist, Relestat) is a second-generation antihistamine and mast cell stabilizer. Epinastine is a topically active, direct H1-receptor antagonist and an inhibitor of the release of histamine from the mast ce...
Status:
US Approved Rx (2011)
First approved in 2001

Class (Stereo):
CHEMICAL (ACHIRAL)



Desloratadine is an active, descarboethoxy metabolite of loratadine. It acts by selective inhibition of H1 histamine receptor and thus provides relief to patients with allergic rhinitis and chronic idiopathic urticaria. Desloratadine was approved by ...
Status:
US Approved Rx (2008)
First approved in 1999

Class (Stereo):
CHEMICAL (ACHIRAL)



Ketotifen is a cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis. Ketotifen was developed in 1970 by Sandoz Pharmac...
Status:
US Approved Rx (2012)
First approved in 1996

Class (Stereo):
CHEMICAL (RACEMIC)



Fexofenadine is a second-generation, long lasting H1-receptor antagonist (antihistamine) which has a selective and peripheral H1-antagonist action. Histamine is a chemical that causes many of the signs that are part of allergic reactions, such as the...
Status:
US Approved Rx (2017)
First approved in 1996

Class (Stereo):
CHEMICAL (RACEMIC)



Azelastine, a phthalazine derivative, is an antihistamine and mast cell stabilizer. Azelastine is oxidatively metabolized to the principal active metabolite, desmethylazelastine, by the cytochrome P450 enzyme system. It is indicated for the relief of...
Status:
US Approved Rx (2015)
First approved in 1996

Class (Stereo):
CHEMICAL (ACHIRAL)



Olopatadine is an antihistamine (as well as anticholinergic and mast cell stabilizer) used to treat itching associated with allergic conjunctivitis (eye allergies). Olopatadine is a selective histamine H1 antagonist that binds to the histamine H1 rec...
Status:
US Approved Rx (2013)
First approved in 1995

Class (Stereo):
CHEMICAL (ABSOLUTE)



Levocetirizine is the active enantiomer of cetirizine. It is inverse agonist of H1 receptors. Levocetirizine hydrochloride was approved for treatment of Allergic Rhinitis and Chronic Idiopathic Urticaria.
Status:
US Approved Rx (2018)
First approved in 1988

Class (Stereo):
CHEMICAL (RACEMIC)



Cetirizine, a human metabolite of hydroxyzine, is an antihistamine; its principal effects are mediated via selective inhibition of peripheral H1 receptors. It is indicated for the relief of nasal and non-nasal symptoms associated with seasonal or per...
Status:
US Approved OTC
First approved in 1949

Class (Stereo):
CHEMICAL (RACEMIC)



Chlorpheniramine is an antihistamine. Chlorpheniramine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine. Chlorpheniramine...
Status:
US Approved OTC
First approved in 1946

Class (Stereo):
CHEMICAL (ACHIRAL)



Diphenhydramine is an antihistamine which is used in the combination with naproxen sodium for the relief of occasional sleeplessness when associated with minor aches and pains. Diphenhydramine has a role nighttime sleep-aid and naproxen sodium is a p...

Showing 1 - 10 of 11 results