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11

Possibly Marketed Outside US

3

US Approved Rx

1

US Previously Marketed

1

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Primary Target

Muscarinic acetylcholine receptor M1

1

Muscarinic acetylcholine receptor M2

1

Muscarinic acetylcholine receptor M3

1

Muscarinic acetylcholine receptor M4

1

Muscarinic acetylcholine receptor M5

1

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Highest Phase

Approved

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Approval Year

Unknown

11

1982

1

2000

1

2009

1

2013

1

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Condition

Chronic obstructive pulmonary disease

1

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Treatment Modality

Primary

1

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CNS Activity

CNS Non-penetrant

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Originator

Theravance, Inc.

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Substance Class

Chemical

14

Structurally Diverse

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INN Stem

Chemical substance(-ine)

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Code System

FDA UNII

16

WIKIPEDIA

16

CAS

15

EPA CompTox

15

PUBCHEM

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Substance Form

Principal Form

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Search results for m root_codes_WIKIPEDIA in WIKIPEDIA (approximate match)

Showing 1 - 10 of 16 results

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REVEFENACIN

G2AE2VE07O

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Status:

US Approved Rx (2018)

First approved in 2018

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Muscarinic acetylcholine receptor M5

Muscarinic acetylcholine receptor M4

Muscarinic acetylcholine receptor M2

Muscarinic acetylcholine receptor M3

Muscarinic acetylcholine receptor M1

Conditions:

Chronic obstructive pulmonary disease

Revefenacin (trade name Yupelri is a long-acting muscarinic antagonist developed by Mylan Ireland ltd for the treatment of chronic obstructive pulmonary disease (COPD). It has similar affinity to the subtypes of muscarinic receptors M1 to M5. In the...

airways, it exhibits pharmacological effects through inhibition of M3 receptor at the smooth muscle leading to bronchodilation. The competitive and reversible nature of antagonism was shown with human and animal origin receptors and isolated organ preparations. In preclinical in vitro as well as in vivo models, prevention of methacholine- and acetylcholine-induced bronchoconstrictive effects was dose-dependent and lasted longer than 24 hours.

2-CHLORO-M-CRESOL

XZT2VD3JL6

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

TETRACHLORO-M-XYLENE

O8XMK3B4S9

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

VERAPHENOL

L9FI83128D

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

M-TOLUIC ACID

1UA7K8EEXT

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

CARBONYL CYANIDE (M-CHLOROPHENYL)HYDRAZONE

4D4NW27CG5

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

oxidative phosphorylation uncoupler activity

3'-HYDROXYCINNAMIC ACID

KWJ2DDJ34H

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

M-ISOPROPYLPHENOL METHYLCARBAMATE

27502G8UZX

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

1,3-BENZENEDIMETHANAMINE

1E84B9YLJD

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

M-ANISIDINE

JXA144KX2I

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

Showing 1 - 10 of 16 results

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