U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Showing 1 - 10 of 101 results

Status:
US Approved Rx (2007)
First approved in 2007

Class (Stereo):
CHEMICAL (ABSOLUTE)



Rotigotine is an agonist at all 5 dopamine receptor subtypes (D1-D5) but binds to the D3 receptor with the highest affinity. It is also an antagonist at α-2-adrenergic receptors and an agonist at the 5HT1A receptors. Rotigotine also inhibits dopamine...
Status:
US Approved Rx (1997)
First approved in 1997

Class (Stereo):
CHEMICAL (RACEMIC)


Conditions:

Fenoldopam (marketed under the brand name Corlopam) is a drug and synthetic benzazepine derivative which acts as a selective D1 receptor partial agonist. Fenoldopam is a rapid-acting vasodilator. It is an agonist for D1-like dopamine receptors and bi...
Status:
US Approved Rx (2008)
First approved in 1978

Class (Stereo):
CHEMICAL (ABSOLUTE)



Bromocriptine is an ergot derivative with potent dopamine receptor agonist activity, which activates post-synaptic dopamine receptors. Bromocriptine is indicated for the treatment of dysfunctions associated with hyperprolactinemia. Bromocriptine ther...
Status:
US Approved Rx (1993)
First approved in 1970

Class (Stereo):
CHEMICAL (ABSOLUTE)



Levodopa (L-DOPA) was first isolated from seedlings of Vicia faba by Marcus Guggenheim in 1913. Levodopa, a dopamine precursor, is an effective and well-tolerated dopamine replacement agent used to treat Parkinson's disease. Oral levodopa has been wi...
Status:
US Approved Rx (1983)
First approved in 1962

Class (Stereo):
CHEMICAL (RACEMIC)


Conditions:

Thioridazine (Mellaril or Melleril) is a piperidine typical antipsychotic drug belonging to the phenothiazine drug group and was previously widely used in the treatment of schizophrenia and psychosis. Thioridazine blocks postsynaptic mesolimbic dopam...
Status:
US Approved Rx (2023)
First approved in 1959

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Fluphenazine is a trifluoro-methyl phenothiazine derivative intended for the management of schizophrenia and other psychotic disorders. Fluphenazine has not been shown effective in the management of behaviorial complications in patients with mental r...
Status:
US Approved Rx (1981)
First approved in 1959

Class (Stereo):
CHEMICAL (ACHIRAL)



Trifluoperazine (Eskazinyl, Eskazine, Jatroneural, Modalina, Stelazine, Terfluzine, Trifluoperaz, Triftazin) is a typical antipsychotic of the phenothiazine chemical class used for the short-term treatment of certain types of anxiety. Trifluoperazine...
Status:
US Approved Rx (2021)
First approved in 1954

Class (Stereo):
CHEMICAL (ACHIRAL)



Chlorpromazine is a psychotropic agent indicated for the treatment of schizophrenia. It also exerts sedative and antiemetic activity. Chlorpromazine has actions at all levels of the central nervous system-primarily at subcortical levels-as well as on...
Status:
US Approved Rx (2021)
First approved in 1946

Class (Stereo):
CHEMICAL (ABSOLUTE)



Methylergometrine (other names include methylergonovine, methylergobasin, methergine, and D-lysergic acid 1-butanolamide) is a synthetic analogue of ergonovine, a psychedelic alkaloid found in ergot, and many species of morning glory. In general, th...
Status:
Investigational

Class (Stereo):
CHEMICAL (RACEMIC)


Metitepine, a psychotropic agent was developed as a non-selective antagonist of serotonin, dopamine, and adrenergic receptors. Metitepine has never been marketed.