Details
Stereochemistry | RACEMIC |
Molecular Formula | C20H24N2S2 |
Molecular Weight | 356.548 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CSC1=CC2=C(SC3=C(CC2N4CCN(C)CC4)C=CC=C3)C=C1
InChI
InChIKey=RLJFTICUTYVZDG-UHFFFAOYSA-N
InChI=1S/C20H24N2S2/c1-21-9-11-22(12-10-21)18-13-15-5-3-4-6-19(15)24-20-8-7-16(23-2)14-17(18)20/h3-8,14,18H,9-13H2,1-2H3
Molecular Formula | C20H24N2S2 |
Molecular Weight | 356.548 |
Charge | 0 |
Count |
|
Stereochemistry | RACEMIC |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Optical Activity | ( + / - ) |
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL224 |
56.0 nM [IC50] | ||
Target ID: CHEMBL1833 Sources: https://www.ncbi.nlm.nih.gov/pubmed/15322733 |
8.68 null [pKi] | ||
Target ID: CHEMBL225 Sources: https://www.ncbi.nlm.nih.gov/pubmed/15322733 |
8.35 null [pKi] | ||
Target ID: CHEMBL214 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27487565 |
71.0 nM [IC50] | ||
Target ID: CHEMBL3371 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25557493 |
4.7 nM [IC50] | ||
Target ID: CHEMBL3155 Sources: https://www.ncbi.nlm.nih.gov/pubmed/24805037 |
1.5 nM [IC50] | ||
Target ID: CHEMBL265 Sources: https://www.ncbi.nlm.nih.gov/pubmed/11784139 |
2.0 nM [Ki] | ||
Target ID: CHEMBL339 Sources: https://www.ncbi.nlm.nih.gov/pubmed/11784139 |
0.4 nM [Ki] |
PubMed
Title | Date | PubMed |
---|---|---|
Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor. | 1991 Aug |
|
Molecular cloning of a serotonin receptor from human brain (5HT1E): a fifth 5HT1-like subtype. | 1992 Jun 15 |
|
Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype. | 1993 Aug 25 |
|
Mouse 5-hydroxytryptamine5A and 5-hydroxytryptamine5B receptors define a new family of serotonin receptors: cloning, functional expression, and chromosomal localization. | 1993 Mar |
|
Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase. | 1993 Nov 5 |
|
Alniditan, a new 5-hydroxytryptamine1D agonist and migraine-abortive agent: ligand-binding properties of human 5-hydroxytryptamine1D alpha, human 5-hydroxytryptamine1D beta, and calf 5-hydroxytryptamine1D receptors investigated with [3H]5-hydroxytryptamine and [3H]alniditan. | 1996 Dec |
|
Cloning, characterization, and chromosomal localization of a human 5-HT6 serotonin receptor. | 1996 Jan |
|
Two amino acid differences in the sixth transmembrane domain are partially responsible for the pharmacological differences between the 5-HT1D beta and 5-HT1E 5-hydroxytryptamine receptors. | 1996 Nov |
|
GR127935 acts as a partial agonist at recombinant human 5-HT1D alpha and 5-HT1D beta receptors. | 1996 Oct 31 |
|
Cloning, expression and pharmacology of a truncated splice variant of the human 5-HT7 receptor (h5-HT7b). | 1997 Sep |
|
Interaction of tryptamine and ergoline compounds with threonine 196 in the ligand binding site of the 5-hydroxytryptamine6 receptor. | 1997 Sep |
|
Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study. | 1998 Aug 21 |
|
Functional characterisation of the human cloned 5-HT7 receptor (long form); antagonist profile of SB-258719. | 1998 Jul |
|
Labelling of recombinant human and native rat serotonin 5-HT1A receptors by a novel, selective radioligand, [3H]-S 15535: definition of its binding profile using agonists, antagonists and inverse agonists. | 1998 Mar |
|
Identification of residues in transmembrane regions III and VI that contribute to the ligand binding site of the serotonin 5-HT6 receptor. | 1998 Nov |
|
The 5-hydroxytryptamine6 receptor-selective radioligand [3H]Ro 63-0563 labels 5-hydroxytryptamine receptor binding sites in rat and porcine striatum. | 1998 Sep |
|
Inverse agonism and constitutive activity as functional correlates of serotonin h5-HT(1B) receptor/G-protein stoichiometry. | 2000 Nov |
|
Specific labelling of serotonin 5-HT(1B) receptors in rat frontal cortex with the novel, phenylpiperazine derivative, [3H]GR125,743. A pharmacological characterization. | 2002 Apr |
|
Molecular cloning and pharmacological characterization of the guinea pig 5-HT1E receptor. | 2004 Jan 26 |
|
Cloned human 5-HT1A receptor pharmacology determined using agonist binding and measurement of cAMP accumulation. | 2004 Oct |
|
Serotonin (5HT), fluoxetine, imipramine and dopamine target distinct 5HT receptor signaling to modulate Caenorhabditis elegans egg-laying behavior. | 2005 Mar |
|
Potential vascular alpha1-adrenoceptor blocking properties of an array of 5-HT receptor ligands in the rat. | 2006 Mar 27 |
|
Pharmacological analysis of the novel, rapid, and potent inactivation of the human 5-Hydroxytryptamine7 receptor by risperidone, 9-OH-Risperidone, and other inactivating antagonists. | 2009 Feb |
|
A repurposing approach identifies off-patent drugs with fungicidal cryptococcal activity, a common structural chemotype, and pharmacological properties relevant to the treatment of cryptococcosis. | 2013 Feb |
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 17:31:38 UTC 2023
by
admin
on
Sat Dec 16 17:31:38 UTC 2023
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Record UNII |
55D94103HL
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Record Status |
Validated (UNII)
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Record Version |
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-
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20229-30-5
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759875
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100000080917
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64203
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m7487
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3207
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4106
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DTXSID2044000
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Metitepine
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101395-30-6
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55D94103HL
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C166815
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SUB08896MIG
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CHEMBL93240
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