Class (Stereo):
CHEMICAL (RACEMIC)
Targets:
Sulindac is a nonsteroidal anti-inflammatory agent (NSAIA) of the arylalkanoic acid class that is marketed in the U.S. by Merck as Clinoril. Like other NSAIAs, it may be used in the treatment of acute or chronic inflammatory conditions. Sulindac is a...
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Sorbinil (also known as CP-45,634), an aldose reductase inhibitor that has been in phase III clinical trials in preventing the development of diabetic retinopathy and neuropathy in persons with insulin-dependent diabetes. However, this research has b...
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Ranirestat (AS-3201, SX-3030, SX-3202) is an oral aldose reductase inhibitor. (-)-enantiomer (AS-3201) is 10 times more potent in inhibition of the aldose reductase and 500 times more potent in the in vivo activity than the corresponding (+)-enantiom...
Ponalrestat is the inhibitor of aldehyde reductase 2 from a number of sources. Ponalrestat blunted Prostaglandin F2 alpha synthesis by preadipocytes in basal and stimulated conditions. Ponalrestat suppresses IL-1 production both in vitro and in vivo,...
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Aldose reductase-IN-1 is an inhibitor of aldose reductase
Lidorestat is a highly potent and selective aldose reductase inhibitor with good oral bioavailability that is reported to improve nerve conduction and reduce cataract formation. Lidorestat reduced mortality rates in hAR transgenic mice. Mice receivin...
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Protocatechuic acid (3,4-dihydroxybenzoic acid, PCA) is a simple phenolic acid. It is found in a large variety of edible plants and possesses various pharmacological activities. This bioactive compound is famous for its biological properties and phar...
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Isovitexin (apigenin-6-C-glucoside), an isomer of vitexin, is found in plants such as pigeon pea, Passiflora, bamboo, mimosa, wheat leaves, rice hull of Oryza sativa and others. Isovitexin is poorly absorbed in the gastrointestinal tract. The highest...
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Sylvatesmin is a furofuran lignin isolated from Forsythia suspense, Osmanthus fragrans and other plants. It protected LDL from lipid peroxidation and demonstrated free radical scavenging activity. Molecular modeling showed that sylvatesmin exhibited ...