Chelerythrine is a kind of benzo[c] phenanthridine alkaloids, which is widely found in plant of Fumariaceae, Papaveraceae, Ranunculaceae and Rutaceae families. Chelerythrine is a potent and specific inhibitor of protein kinase C. In addition chelerythrine inhibits pro-survival protein Bcl(XL) thereby inducing apoptosis. It exerts antitumor properties.

DTP3 is a D-tripeptide with a molecular weight of 525 Da, which retained all the main characteristics of the parental D-tetrapeptides in terms of bioactivity and specificity, including subnanomolar activity and high stability in vitro and potent and selective capacity to kill MM cells via apoptosis. DTP3 is a selective MKK7 binder, driving to a sustained JNK activation and consequent death of MM cell lines expressing GADD45β. DTP3 is about to enter clinical studies as a potential treatment for multiple myeloma.