Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C26H35N7O5 |
| Molecular Weight | 525.6 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(=O)N[C@H](CC1=CC=C(O)C=C1)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CC2=CC=CC=C2)C(N)=O
InChI
InChIKey=AOUZPXZGMZUQQS-YPAWHYETSA-N
InChI=1S/C26H35N7O5/c1-16(34)31-22(15-18-9-11-19(35)12-10-18)25(38)32-20(8-5-13-30-26(28)29)24(37)33-21(23(27)36)14-17-6-3-2-4-7-17/h2-4,6-7,9-12,20-22,35H,5,8,13-15H2,1H3,(H2,27,36)(H,31,34)(H,32,38)(H,33,37)(H4,28,29,30)/t20-,21-,22-/m1/s1
| Molecular Formula | C26H35N7O5 |
| Molecular Weight | 525.6 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
DescriptionCurator's Comment: description was created based on several sources, including:
https://www.ncbi.nlm.nih.gov/pubmed/27441658 | http://adisinsight.springer.com/drugs/800047384
Curator's Comment: description was created based on several sources, including:
https://www.ncbi.nlm.nih.gov/pubmed/27441658 | http://adisinsight.springer.com/drugs/800047384
DTP3 is a D-tripeptide with a molecular weight of 525 Da, which retained all the main characteristics of the parental D-tetrapeptides in terms of bioactivity and specificity, including subnanomolar activity and high stability in vitro and potent and selective capacity to kill MM cells via apoptosis. DTP3 is a selective MKK7 binder, driving to a sustained JNK activation and consequent death of MM cell lines expressing GADD45β. DTP3 is about to enter clinical studies as a potential treatment for multiple myeloma.
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 11:53:31 GMT 2023
by
admin
on
Sat Dec 16 11:53:31 GMT 2023
|
| Record UNII |
7UXW0T8LS8
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Code | English | ||
|
Systematic Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
7UXW0T8LS8
Created by
admin on Sat Dec 16 11:53:31 GMT 2023 , Edited by admin on Sat Dec 16 11:53:31 GMT 2023
|
PRIMARY | |||
|
1809784-29-9
Created by
admin on Sat Dec 16 11:53:31 GMT 2023 , Edited by admin on Sat Dec 16 11:53:31 GMT 2023
|
PRIMARY | |||
|
86295191
Created by
admin on Sat Dec 16 11:53:31 GMT 2023 , Edited by admin on Sat Dec 16 11:53:31 GMT 2023
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
ACTIVE MOIETY |
