Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C26H35N7O5 |
Molecular Weight | 525.6 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 3 / 3 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(=O)N[C@H](CC1=CC=C(O)C=C1)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CC2=CC=CC=C2)C(N)=O
InChI
InChIKey=AOUZPXZGMZUQQS-YPAWHYETSA-N
InChI=1S/C26H35N7O5/c1-16(34)31-22(15-18-9-11-19(35)12-10-18)25(38)32-20(8-5-13-30-26(28)29)24(37)33-21(23(27)36)14-17-6-3-2-4-7-17/h2-4,6-7,9-12,20-22,35H,5,8,13-15H2,1H3,(H2,27,36)(H,31,34)(H,32,38)(H,33,37)(H4,28,29,30)/t20-,21-,22-/m1/s1
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/25314077Curator's Comment: description was created based on several sources, including:
https://www.ncbi.nlm.nih.gov/pubmed/27441658 | http://adisinsight.springer.com/drugs/800047384
Sources: https://www.ncbi.nlm.nih.gov/pubmed/25314077
Curator's Comment: description was created based on several sources, including:
https://www.ncbi.nlm.nih.gov/pubmed/27441658 | http://adisinsight.springer.com/drugs/800047384
DTP3 is a D-tripeptide with a molecular weight of 525 Da, which retained all the main characteristics of the parental D-tetrapeptides in terms of bioactivity and specificity, including subnanomolar activity and high stability in vitro and potent and selective capacity to kill MM cells via apoptosis. DTP3 is a selective MKK7 binder, driving to a sustained JNK activation and consequent death of MM cell lines expressing GADD45β. DTP3 is about to enter clinical studies as a potential treatment for multiple myeloma.
Originator
Sources: https://www.ncbi.nlm.nih.gov/pubmed/25314077
Curator's Comment: http://kesios.com/about-us-2/
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL3530 |
64.8 nM [Kd] | ||
Target ID: GADD45β/MKK7 complex Sources: https://www.ncbi.nlm.nih.gov/pubmed/25314077 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Unknown Approved UseUnknown |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/25314077
14.5 mg/kg/day
Route of Administration:
Other
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/25314077
IC50 value of DTP3 at 48 hr in CD138+ cells from the patients with multiple myeloma is 28.2 nM
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ACTIVE MOIETY