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Status:
Other
Class (Stereo):
CHEMICAL (UNKNOWN)
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
MFZ 10-7 is a high affinity negative allosteric modulator at the mGlu5 receptor (Ki = 0.67 nM). MFZ 10-7 demonstrates anxyolitic properties in mouse models. Intraperitoneal administration of MFZ 10-7 inhibited intravenous cocaine self-administration, cocaine-induced reinstatement of drug-seeking behavior and cocaine-associated cue-induced cocaine-seeking behavior in rats.
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Methoxy-PEPy is a selective ligand for the Metabotropic Glutamate Subtype 5 (mGlu5) Receptor. [3H]Methoxy-PEPy is used as a radiolabel to study mGlu5 R distribution and binding with other agents.
