Dihydrotanshinone I (DHI), a diterpenoid first isolated from the roots of Salvia miltiorrhiza, is a relatively high affinity inhibitor of human AChE. Dihydrotanshinone I (10 and 25 mg/kg) significantly attenuates atherosclerotic plaque formation, alteres serum lipid profile, decreases oxidative stress and shrinks necrotic core areas in ApoE-/- mice. Dihydrotanshinone I dramatically inhibits the enhanced expression of LOX-1, NOX4, and NF-κB in aorta. Dihydrotanshinone I treatment can improve cardiac function, reduce infarct size, ameliorate the variations in myocardial zymogram and histopathological disorders, decrease 20-HETE generation, and regulate apoptosis-related protein in myocardial ischemia-reperfusion rats.

P7C3 is a chemical compound belongs to a class of proneurogenic compounds that are potential nicotinamide phosphoribosyltransferase (NAMPT) activators, and might shed light on future drug development in neurogenesis restoration. This compound protects newborn neurons in the dentate gyrus by mitigating cell death. Also enhances learning and memory in aged rats. In addition on animal models was shown, that P7C3 is sufficient to restore the neurogenic deficits observed in the Ts65Dn mouse model of Down Syndrome, and also was discovered, that P7C3 might provide a basis for the discovery and optimization of pharmacologic agents for the treatment of amyotrophic lateral sclerosis (ALS) and for the treatment of patients with Parkinson disease (PD).

3-O-methyldopa (3-OMD) is a metabolite of L-3,4-dihydroxyphenylalanine (L-DOPA), a drug used for the treatment of Parkinson's disease patients. 3-OMD is formed by catechol-O-methyltransferase. 3-OMD may be responsible for the side effects of L-DOPA.

Erastin is antitumor agent, exhibiting selectivity for tumor cells bearing oncogenic RAS. Erastin is a ferroptosis activator; it induces oxidative, non-apoptotic cell death in tumors by acting directly on voltage-dependent anion channel 2 (VDAC2).

KU0058948 is an inhibitor of Poly(ADP-ribose) polymerase (PARP). In addition KU0058948 was shown to activate extracellular signal-regulated kinase 8 (ERK8). It affects viability of leukemia, pancreatic and endometrial cancer cells.