| Stereochemistry | RACEMIC |
| Molecular Formula | C30H31ClN4O4 |
| Molecular Weight | 547.045 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCOC1=CC=CC=C1N2C(=O)C3=C(C=CC=C3)N=C2C(C)N4CCN(CC4)C(=O)COC5=CC=C(Cl)C=C5
InChI
InChIKey=BKQFRNYHFIQEKN-UHFFFAOYSA-N
InChI=1S/C30H31ClN4O4/c1-3-38-27-11-7-6-10-26(27)35-29(32-25-9-5-4-8-24(25)30(35)37)21(2)33-16-18-34(19-17-33)28(36)20-39-23-14-12-22(31)13-15-23/h4-15,21H,3,16-20H2,1-2H3
| Molecular Formula | C30H31ClN4O4 |
| Molecular Weight | 547.045 |
| Charge | 0 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
Originator
Approval Year
PubMed
Sample Use Guides
Erastin-induced cell death in human cancer cells involves DFO-sensitive ROS accumulation and can occur in cells lacking a functional electron transport chain (ETC). It was shown, that in erastin-treated (10 µM, 6 hrs) HT-1080 cells, observed no increase in MitoSOX-sensitive mitochondrial ROS production. KRAS-mutant 143B osteosarcoma cells incapable of ETC-dependent ROS formation, due to the depletion of mitochondrial DNA (mtDNA)-encoded transcripts, were as sensitive to erastin and RSL3 as matched mtDNA-wild-type (ρ+) cells.