Details
Stereochemistry | RACEMIC |
Molecular Formula | C30H31ClN4O4 |
Molecular Weight | 547.045 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCOC1=C(C=CC=C1)N2C(=O)C3=CC=CC=C3N=C2C(C)N4CCN(CC4)C(=O)COC5=CC=C(Cl)C=C5
InChI
InChIKey=BKQFRNYHFIQEKN-UHFFFAOYSA-N
InChI=1S/C30H31ClN4O4/c1-3-38-27-11-7-6-10-26(27)35-29(32-25-9-5-4-8-24(25)30(35)37)21(2)33-16-18-34(19-17-33)28(36)20-39-23-14-12-22(31)13-15-23/h4-15,21H,3,16-20H2,1-2H3
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL6190 Sources: https://www.ncbi.nlm.nih.gov/pubmed/17568748 |
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Target ID: ferroptosis Sources: https://www.ncbi.nlm.nih.gov/pubmed/22632970 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Primary | Unknown Approved UseUnknown |
PubMed
Title | Date | PubMed |
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Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells. | 2003 Mar |
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Mitochondrial voltage-dependent anion channels (VDACs) as novel pharmacological targets for anti-cancer agents. | 2008 Jun |
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Caspase-independent cell death is involved in the negative effect of EGF receptor inhibitors on cisplatin in non-small cell lung cancer cells. | 2013 Feb 15 |
Sample Use Guides
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/22632970
Erastin-induced cell death in human cancer cells involves DFO-sensitive ROS accumulation and can occur in cells lacking a functional electron transport chain (ETC). It was shown, that in erastin-treated (10 µM, 6 hrs) HT-1080 cells, observed no increase in MitoSOX-sensitive mitochondrial ROS production. KRAS-mutant 143B osteosarcoma cells incapable of ETC-dependent ROS formation, due to the depletion of mitochondrial DNA (mtDNA)-encoded transcripts, were as sensitive to erastin and RSL3 as matched mtDNA-wild-type (ρ+) cells.
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11214940
Created by
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Erastin
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571203-78-6
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ZJA3NS42T9
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DTXSID80458949
Created by
admin on Sat Dec 16 16:56:56 GMT 2023 , Edited by admin on Sat Dec 16 16:56:56 GMT 2023
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SUBSTANCE RECORD