Inxight Drugs

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29

Investigational

7

Possibly Marketed Outside US

5

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Primary Target

Acetylcholinesterase

2

CYP4C7 (Corpora allata cytochrome P450)

1

Dermatophagoides farinae viability

1

Insect juvenile hormones

1

Nicotinic acetylcholine receptor

1

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Highest Phase

Approved

4

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Approval Year

Unknown

40

2000

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Condition

Unknown

2

Ectoparasitic infestations

1

Flea infestations

1

Head lice infestation

1

Mite infestation

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Treatment Modality

Curative

2

Preventing

1

Primary

1

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CNS Activity

CNS Penetrant

3

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Originator

Sumitomo Chemical

2

Ciba-Geigy

1

Dow Chemical Co.

1

Henrick, C.A.

1

Takeda Chemical Industries

1

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Substance Class

Chemical

40

Mixture

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Code System

FDA UNII

41

CAS

40

EPA CompTox

40

PUBCHEM

40

ALANWOOD

38

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Substance Form

Principal Form

38

Salts, Hydrates, Esters, etc.

3

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Showing 1 - 10 of 41 results

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STIROFOS

DM33MW89QU

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Status:

Investigational

Class (Stereo):

CHEMICAL (ACHIRAL)

(E)-Tetrachlorovinphos is an (E)- isomer of Tetrachlorovinphos. Tetrachlorovinphos is an organophosphate cholinesterase inhibitor that is used as an insecticide. Tetrachlorvinphos was introduced and first used commercially in 1966 in the USA. Tetrach...

lorvinphos was originally registered for use on various food crops, livestock, pet animals. Tetrachlorvinphos is applied dermally to livestock to control flies and mites. It is used as an oral larvicide in cattle, hog, goats and horses; in cattle ear tags to control flies; in cattle feedlots; in poultry dust boxes to control poultry mites; and in poultry houses. Tetrachlorvinphos also is used in pet sleeping areas and pet flea collars and to control flies around refuse sites, recreational areas, and for general outdoor treatment. Tetrachlorvinphos can cause cholinesterase inhibition in humans; that is, it can overstimulate the nervous system causing nausea, dizziness, confusion, and at very high exposures (e.g., accidents or major spills), respiratory paralysis and death. In 2014, the Natural Resources Defense Council (NRDC) filed a lawsuit against the United States Environmental Protection Agency (EPA) seeking EPA to respond to NRDC’s 2009 petition to ban tetrachlorvinphos in common pet flea treatment products. Tetrachlorvinphos is reportedly registered for use in Canada, South Africa, and Australia.

CARBOSULFAN

V1DGN4AK6G

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Status:

Investigational

Class (Stereo):

CHEMICAL (ACHIRAL)

CHLORPYRIFOS-METHYL

O49S38267J

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Status:

Investigational

Class (Stereo):

CHEMICAL (ACHIRAL)

Chlorpyrifos-methyl is a broad-spectrum organophosphorous insecticide and potential toxic pollutant widely used in agriculture and effective against a wide range of insect pests in commercial importance crops. Chlorpyrifos-methyl have endocrine disr...

uption activity, especially anti-androgenic effects and Chlorpyrifos-methyl administration leads to hepatotoxicity and neurotoxicity in mammals. The fish exposed to chlorpyrifos-methyl exhibited behavioral changes in the form of neurotoxin toxicity: less general activity than control group, loss of equilibrium, erratic swimming and staying motionless at a certain location

PIRIMIPHOS-METHYL

2VQZ4PK548

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Status:

Investigational

Class (Stereo):

CHEMICAL (ACHIRAL)

DIMPYLATE

YUS1M1Q929

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Status:

Investigational

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Acetylcholinesterase

Conditions:

Dimpylate (diazinon) is a nonsystemic organophosphate insecticide, an inhibitor of the enzyme acetylcholinesterase (AChE), which hydrolyzes the neurotransmitter acetylcholine (ACh) in cholinergic synapses and neuromuscular junctions. This results in ...

abnormal accumulation of ACh in the nervous system. Dimpylate was first registered for use in the USA in 1956. It was developed as an insecticide, acaricide, and nematicide for use on a variety of pests for control of soil insects and pests of fruit, vegetables, and forage and field crops. It had been used extensively in home and garden applications, in formulations designed to prevent such pests as crickets or cockroaches from infesting homes or offices, and in pet collars. Due to the emerging health and ecological risks posed by diazinon, manufacturers agreed to phase out and cancel all residential products. Manufacturing of indoor use products containing dimpylatewas discontinued in 2001; manufacture of non-agricultural outdoor use products containing dimpylate was discontinued in 2003.

FLUPYRADIFURONE

8H7JT159D0

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

BISTRIFLURON

0806M8CX7O

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Other

Class (Stereo):

CHEMICAL (ACHIRAL)

ACETOPROLE

6PH9942U0U

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Other

Class (Stereo):

CHEMICAL (RACEMIC)

FLUFENERIM

JMT14E2D3Z

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Other

Class (Stereo):

CHEMICAL (RACEMIC)

KINOPRENE

6IW5NLQ04R

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Status:

Other

Class (Stereo):

CHEMICAL (RACEMIC)

Showing 1 - 10 of 41 results

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