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Development Status

US Approved Rx

6

Investigational

1

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Primary Target

Potassium-transporting ATPase

6

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Highest Phase

Approved

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Approval Year

1995

6

Unknown

1

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Condition

Active duodenal ulcer

6

Erosive esophagitis

6

Gastric ulcer

6

Gastroesophageal reflux disease

6

Heartburn

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Treatment Modality

Curative

6

Primary

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CNS Activity

CNS Active

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Originator

Takeda Chemical Industries

6

Aktiebolag Hassle

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Substance Class

Chemical

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Code System

CAS

7

FDA UNII

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PUBCHEM

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EPA CompTox

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SMS_ID

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ATC Level 1

ALIMENTARY TRACT AND METABOLISM

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ATC Level 2

DRUGS FOR ACID RELATED DISORDERS

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ATC Level 3

DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)

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ATC Level 4

Proton pump inhibitors

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Combinations for eradication of Helicobacter pylori

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Substance Form

Salts, Hydrates, Esters, etc.

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Principal Form

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Showing 1 - 7 of 7 results

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LANSOPRAZOLE

0K5C5T2QPG

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Status:

US Approved Rx (2012)

First approved in 1995

Class (Stereo):

CHEMICAL (RACEMIC)

Targets:

Potassium-transporting ATPase

Potassium-transporting ATPase

Potassium-transporting ATPase

Conditions:

Active duodenal ulcer

Gastroesophageal reflux disease

Erosive esophagitis

Gastroesophageal reflux disease

Active duodenal ulcer

Levolansoprazole is the levorotary (L-enantiomer) form of proton-pump inhibitor (PPI) Lansoprazole. Lansoprazole is a racemic 1:1 mixture of the enantiomers dexlansoprazole (Dexilant, formerly named Kapidex) and Levolansoprazole. Lansoprazole has use...

d to the treatment of acid-reflux disorders (GERD), peptic ulcer disease, H. pylori eradication, and prevention of gastrointestinal bleeds with NSAID use. Levolansoprazole is extensively metabolized in the liver. Two metabolites have been identified in measurable quantities in plasma (the hydroxylated sulfinyl and sulfone derivatives of Levolansoprazole).

TIMOPRAZOLE

95H6S1X9CC

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Status:

Investigational

Class (Stereo):

CHEMICAL (RACEMIC)

Timoprazole is a substituted benzimidazole patented by Aktiebolag Hassle as an antisecretory agent that inhibits gastric acid secretion by interference with (H+-K+)-ATPase. Timoprazole given orally was found to be cytoprotective for the stomach when ...

given 30 min prior to a challenge to boiling water, ethanol, or HCl. Timoprazole also prevented necrosis of the mucosa and acute ulcerations induced by alcohol in the rat fundus, as evaluated by histopathology.

AG-2000 FREE BASE

7EMR32786O

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Status:

US Approved Rx (2012)

First approved in 1995

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Potassium-transporting ATPase

Potassium-transporting ATPase

Potassium-transporting ATPase

Conditions:

Active duodenal ulcer

Gastroesophageal reflux disease

Erosive esophagitis

Gastroesophageal reflux disease

Active duodenal ulcer

Levolansoprazole is the levorotary (L-enantiomer) form of proton-pump inhibitor (PPI) Lansoprazole. Lansoprazole is a racemic 1:1 mixture of the enantiomers dexlansoprazole (Dexilant, formerly named Kapidex) and Levolansoprazole. Lansoprazole has use...

d to the treatment of acid-reflux disorders (GERD), peptic ulcer disease, H. pylori eradication, and prevention of gastrointestinal bleeds with NSAID use. Levolansoprazole is extensively metabolized in the liver. Two metabolites have been identified in measurable quantities in plasma (the hydroxylated sulfinyl and sulfone derivatives of Levolansoprazole).

LEVOLANSOPRAZOLE

FB55O16184

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Status:

US Approved Rx (2012)

First approved in 1995

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Potassium-transporting ATPase

Potassium-transporting ATPase

Potassium-transporting ATPase

Conditions:

Active duodenal ulcer

Gastroesophageal reflux disease

Erosive esophagitis

Gastroesophageal reflux disease

Active duodenal ulcer

Levolansoprazole is the levorotary (L-enantiomer) form of proton-pump inhibitor (PPI) Lansoprazole. Lansoprazole is a racemic 1:1 mixture of the enantiomers dexlansoprazole (Dexilant, formerly named Kapidex) and Levolansoprazole. Lansoprazole has use...

d to the treatment of acid-reflux disorders (GERD), peptic ulcer disease, H. pylori eradication, and prevention of gastrointestinal bleeds with NSAID use. Levolansoprazole is extensively metabolized in the liver. Two metabolites have been identified in measurable quantities in plasma (the hydroxylated sulfinyl and sulfone derivatives of Levolansoprazole).

DEXLANSOPRAZOLE SESQUIHYDRATE

HS2S9VK3NH

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Status:

US Approved Rx (2012)

First approved in 1995

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Potassium-transporting ATPase

Potassium-transporting ATPase

Potassium-transporting ATPase

Conditions:

Active duodenal ulcer

Gastroesophageal reflux disease

Erosive esophagitis

Gastroesophageal reflux disease

Active duodenal ulcer

Levolansoprazole is the levorotary (L-enantiomer) form of proton-pump inhibitor (PPI) Lansoprazole. Lansoprazole is a racemic 1:1 mixture of the enantiomers dexlansoprazole (Dexilant, formerly named Kapidex) and Levolansoprazole. Lansoprazole has use...

d to the treatment of acid-reflux disorders (GERD), peptic ulcer disease, H. pylori eradication, and prevention of gastrointestinal bleeds with NSAID use. Levolansoprazole is extensively metabolized in the liver. Two metabolites have been identified in measurable quantities in plasma (the hydroxylated sulfinyl and sulfone derivatives of Levolansoprazole).

LANSOPRAZOLE SODIUM

GV9NY1U369

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Status:

US Approved Rx (2012)

First approved in 1995

Class (Stereo):

CHEMICAL (RACEMIC)

Targets:

Potassium-transporting ATPase

Potassium-transporting ATPase

Potassium-transporting ATPase

Conditions:

Active duodenal ulcer

Gastroesophageal reflux disease

Erosive esophagitis

Gastroesophageal reflux disease

Active duodenal ulcer

Levolansoprazole is the levorotary (L-enantiomer) form of proton-pump inhibitor (PPI) Lansoprazole. Lansoprazole is a racemic 1:1 mixture of the enantiomers dexlansoprazole (Dexilant, formerly named Kapidex) and Levolansoprazole. Lansoprazole has use...

d to the treatment of acid-reflux disorders (GERD), peptic ulcer disease, H. pylori eradication, and prevention of gastrointestinal bleeds with NSAID use. Levolansoprazole is extensively metabolized in the liver. Two metabolites have been identified in measurable quantities in plasma (the hydroxylated sulfinyl and sulfone derivatives of Levolansoprazole).

DEXLANSOPRAZOLE

UYE4T5I70X

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Status:

US Approved Rx (2012)

First approved in 1995

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Potassium-transporting ATPase

Potassium-transporting ATPase

Potassium-transporting ATPase

Conditions:

Active duodenal ulcer

Gastroesophageal reflux disease

Erosive esophagitis

Gastroesophageal reflux disease

Active duodenal ulcer

Levolansoprazole is the levorotary (L-enantiomer) form of proton-pump inhibitor (PPI) Lansoprazole. Lansoprazole is a racemic 1:1 mixture of the enantiomers dexlansoprazole (Dexilant, formerly named Kapidex) and Levolansoprazole. Lansoprazole has use...

d to the treatment of acid-reflux disorders (GERD), peptic ulcer disease, H. pylori eradication, and prevention of gastrointestinal bleeds with NSAID use. Levolansoprazole is extensively metabolized in the liver. Two metabolites have been identified in measurable quantities in plasma (the hydroxylated sulfinyl and sulfone derivatives of Levolansoprazole).

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