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Details

Stereochemistry RACEMIC
Molecular Formula C13H11N3OS
Molecular Weight 257.311
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TIMOPRAZOLE

SMILES

[O-][S+](CC1=CC=CC=N1)C2=NC3=CC=CC=C3N2

InChI

InChIKey=HBDKFZNDMVLSHM-UHFFFAOYSA-N
InChI=1S/C13H11N3OS/c17-18(9-10-5-3-4-8-14-10)13-15-11-6-1-2-7-12(11)16-13/h1-8H,9H2,(H,15,16)

HIDE SMILES / InChI
Timoprazole is a substituted benzimidazole patented by Aktiebolag Hassle as an antisecretory agent that inhibits gastric acid secretion by interference with (H+-K+)-ATPase. Timoprazole given orally was found to be cytoprotective for the stomach when given 30 min prior to a challenge to boiling water, ethanol, or HCl. Timoprazole also prevented necrosis of the mucosa and acute ulcerations induced by alcohol in the rat fundus, as evaluated by histopathology.

Approval Year

PubMed

PubMed

TitleDatePubMed
Chemistry of covalent inhibition of the gastric (H+, K+)-ATPase by proton pump inhibitors.
2004 Jun 30
Patents
Name Type Language
TIMOPRAZOLE
INN  
INN  
Official Name English
2-((2-PYRIDYLMETHYL)SULFINYL)BENZIMIDAZOLE
Systematic Name English
timoprazole [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29723
Created by admin on Sat Dec 16 17:53:44 GMT 2023 , Edited by admin on Sat Dec 16 17:53:44 GMT 2023
Code System Code Type Description
MESH
C038402
Created by admin on Sat Dec 16 17:53:44 GMT 2023 , Edited by admin on Sat Dec 16 17:53:44 GMT 2023
PRIMARY
EPA CompTox
DTXSID40866622
Created by admin on Sat Dec 16 17:53:44 GMT 2023 , Edited by admin on Sat Dec 16 17:53:44 GMT 2023
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FDA UNII
95H6S1X9CC
Created by admin on Sat Dec 16 17:53:44 GMT 2023 , Edited by admin on Sat Dec 16 17:53:44 GMT 2023
PRIMARY
WIKIPEDIA
Timoprazole
Created by admin on Sat Dec 16 17:53:44 GMT 2023 , Edited by admin on Sat Dec 16 17:53:44 GMT 2023
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ChEMBL
CHEMBL9861
Created by admin on Sat Dec 16 17:53:44 GMT 2023 , Edited by admin on Sat Dec 16 17:53:44 GMT 2023
PRIMARY
SMS_ID
100000077206
Created by admin on Sat Dec 16 17:53:44 GMT 2023 , Edited by admin on Sat Dec 16 17:53:44 GMT 2023
PRIMARY
NCI_THESAURUS
C80634
Created by admin on Sat Dec 16 17:53:44 GMT 2023 , Edited by admin on Sat Dec 16 17:53:44 GMT 2023
PRIMARY
CAS
57237-97-5
Created by admin on Sat Dec 16 17:53:44 GMT 2023 , Edited by admin on Sat Dec 16 17:53:44 GMT 2023
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INN
3985
Created by admin on Sat Dec 16 17:53:44 GMT 2023 , Edited by admin on Sat Dec 16 17:53:44 GMT 2023
PRIMARY
PUBCHEM
72171
Created by admin on Sat Dec 16 17:53:44 GMT 2023 , Edited by admin on Sat Dec 16 17:53:44 GMT 2023
PRIMARY
EVMPD
SUB11071MIG
Created by admin on Sat Dec 16 17:53:44 GMT 2023 , Edited by admin on Sat Dec 16 17:53:44 GMT 2023
PRIMARY