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Details

Stereochemistry RACEMIC
Molecular Formula C13H11N3OS
Molecular Weight 257.311
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TIMOPRAZOLE

SMILES

[O-][S+](CC1=CC=CC=N1)C2=NC3=CC=CC=C3N2

InChI

InChIKey=HBDKFZNDMVLSHM-UHFFFAOYSA-N
InChI=1S/C13H11N3OS/c17-18(9-10-5-3-4-8-14-10)13-15-11-6-1-2-7-12(11)16-13/h1-8H,9H2,(H,15,16)

HIDE SMILES / InChI

Molecular Formula C13H11N3OS
Molecular Weight 257.311
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Timoprazole is a substituted benzimidazole patented by Aktiebolag Hassle as an antisecretory agent that inhibits gastric acid secretion by interference with (H+-K+)-ATPase. Timoprazole given orally was found to be cytoprotective for the stomach when given 30 min prior to a challenge to boiling water, ethanol, or HCl. Timoprazole also prevented necrosis of the mucosa and acute ulcerations induced by alcohol in the rat fundus, as evaluated by histopathology.

Originator

Approval Year

PubMed

Substance Class Chemical
Record UNII
95H6S1X9CC
Record Status Validated (UNII)
Record Version