LANSOPRAZOLE

Details

Stereochemistry	RACEMIC
Molecular Formula	C16H14F3N3O2S
Molecular Weight	369.361
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=C(C[S+]([O-])C2=NC3=C(N2)C=CC=C3)N=CC=C1OCC(F)(F)F

InChI

InChIKey=MJIHNNLFOKEZEW-UHFFFAOYSA-N

InChI=1S/C16H14F3N3O2S/c1-10-13(20-7-6-14(10)24-9-16(17,18)19)8-25(23)15-21-11-4-2-3-5-12(11)22-15/h2-7H,8-9H2,1H3,(H,21,22)

HIDE SMILES / InChI

Description
Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208056lbl.pdfhttp://www.accessdata.fda.gov/drugsatfda_docs/label/2002/21-428lbl.pdf
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/22950496

Lansoprazole is a proton pump inhibitor, which prevents the stomach from producing acid. Lansoprazole has been marketed for many years and is one of several proton-pump inhibitors (PPI's). It was used for the treatment of acid-reflux disorders (GERD), peptic ulcer disease, H. pylori eradication, and prevention of gastrointestinal bleeds with NSAID use. Lansoprazole belongs to a class of ant secretory compounds, the substituted benzimidazoles, that do not exhibit anticholinergic or histamine H2-receptor antagonist properties, but that suppress gastric acid secretion by specific inhibition of the (H+, K+ )-ATPase enzyme system at the secretory surface of the gastric parietal cell. Because this enzyme system is regarded as the acid (proton) pump within the parietal cell, lansoprazole has been characterized as a gastric acid-pump inhibitor, in that it blocks the final step of acid production. This effect is dose-related and leads to inhibition of both basal and stimulated gastric acid secretion irrespective of the stimulus. Lansoprazole is extensively metabolized in the liver. Two metabolites have been identified in measurable quantities in plasma (the hydroxylated sulfinyl and sulfone derivatives of lansoprazole). These metabolites have very little or no antisecretory activity. Lansoprazole is thought to be transformed into two active species which inhibit acid secretion by (H+, K+ )-ATPase within the parietal cell canaliculus, but are not present in the systemic circulation. The plasma elimination half-life of lansoprazole does not reflect its duration of suppression of gastric acid secretion. Thus, the plasma elimination half-life is less than two hours, while the acid inhibitory effect lasts more than 24 hours.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Potency
Potassium-transporting ATPase 32 Target ID: CHEMBL2095173 Sources: https://www.ncbi.nlm.nih.gov/pubmed/11693467	Inhibitor 8228
Potassium-transporting ATPase 32 Target ID: CHEMBL2095173 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20974316	Inhibitor 8228
Potassium-transporting ATPase 32 Target ID: CHEMBL2095173 Sources: http://www.sciencedirect.com/science/article/pii/000629529190584R?via%3Dihub	Inhibitor 8228	5.2 µM [IC50]

Conditions

Condition	Modality	Highest Phase	Product
Active duodenal ulcer 6 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2002/21-428lbl.pdf	Primary	Approved 8360	PREVACID Approved Use Use •treats frequent heartburn (occurs 2 or more days a week) •not intended for immediate relief of heartburn; this drug may take 1 to 4 days for full effect Launch Date 1.0306656E12
Gastric ulcer 66 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2002/21-428lbl.pdf	Primary	Approved 8360	PREVACID Approved Use Use •treats frequent heartburn (occurs 2 or more days a week) •not intended for immediate relief of heartburn; this drug may take 1 to 4 days for full effect Launch Date 1.0306656E12
Gastroesophageal reflux disease 60 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2002/21-428lbl.pdf	Primary	Approved 8360	PREVACID Approved Use Use •treats frequent heartburn (occurs 2 or more days a week) •not intended for immediate relief of heartburn; this drug may take 1 to 4 days for full effect Launch Date 1.0306656E12
Erosive esophagitis 7 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208056lbl.pdf	Primary	Approved 8360	DEXILANT Approved Use DEXILANT is a proton pump inhibitor (PPI) indicated for: •Healing of all grades of erosive esophagitis (EE). (1.1) •Maintaining healing of EE and relief of heartburn. (1.2) •Treating heartburn associated with symptomatic non-erosive gastroesophageal reflux disease (GERD). (1.3) 1.1 Healing of Erosive Esophagitis DEXILANT is indicated for healing of all grades of erosive esophagitis (EE) for up to eight weeks. 1.2 Maintenance of Healed Erosive Esophagitis DEXILANT is indicated to maintain healing of EE and relief of heartburn for up to six months. 1.3 Symptomatic Non-Erosive Gastroesophageal Reflux Disease DEXILANT is indicated for the treatment of heartburn associated with symptomatic non-erosive gastroesophageal reflux disease (GERD) for four weeks. Launch Date 1.23327362E12
Heartburn 24 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208056lbl.pdf	Curative	Approved 8360	DEXILANT Approved Use DEXILANT is a proton pump inhibitor (PPI) indicated for: •Healing of all grades of erosive esophagitis (EE). (1.1) •Maintaining healing of EE and relief of heartburn. (1.2) •Treating heartburn associated with symptomatic non-erosive gastroesophageal reflux disease (GERD). (1.3) 1.1 Healing of Erosive Esophagitis DEXILANT is indicated for healing of all grades of erosive esophagitis (EE) for up to eight weeks. 1.2 Maintenance of Healed Erosive Esophagitis DEXILANT is indicated to maintain healing of EE and relief of heartburn for up to six months. 1.3 Symptomatic Non-Erosive Gastroesophageal Reflux Disease DEXILANT is indicated for the treatment of heartburn associated with symptomatic non-erosive gastroesophageal reflux disease (GERD) for four weeks. Launch Date 1.23327362E12
Active duodenal ulcer 6 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2002/21-428lbl.pdf	Primary	Approved 8360	PREVACID Approved Use INDICATIONS AND USAGE. Short-Term Treatment of Active Duodenal Ulcer PREVACID is indicated for short-term treatment (up to 4 weeks) for healing and symptom relief of active duodenal ulcer. H. pylori Eradication to Reduce the Risk of Duodenal Ulcer Recurrence. Triple Therapy: PREVACID/amoxicillin/clarithromycin. PREVACID in combination with amoxicillin plus clarithromycin as triple therapy, is indicated for the treatment of patients with H. pylori infection and duodenal ulcer disease (active or one-year history of a duodenal ulcer) to eradicate H. pylori. Eradication of H. pylori has been shown to reduce the risk of duodenal ulcer recurrence. Dual Therapy: PREVACID/amoxicillin. PREVACID in combination with amoxicillin as dual therapy, is indicated for the treatment of patients with H. pylori infection and duodenal ulcer disease (active or one-year history of a duodenal ulcer) who are either allergic or intolerant to clarithromycin or in whom resistance to clarithromycin is known or suspected. Eradication of H. pylori has been shown to reduce the risk of duodenal ulcer recurrence. Maintenance of Healed Duodenal Ulcers PREVACID is indicated to maintain healing of duodenal ulcers. Controlled studies do not extend beyond 12 months. Short-Term Treatment of Active Benign Gastric Ulcer PREVACID is indicated for short-term treatment (up to 8 weeks) for healing and symptom relief of active benign gastric ulcer Healing of NSAID-Associated Gastric Ulcer PREVACID IS INDICATED FOR THE TREATMENT OF NSAID-ASSOCIATED GASTRIC ULCER IN PATIENTS WHO CONTINUE NSAID USE. CONTROLLED STUDIES DID NOT EXTEND BEYOND 8 WEEKS. Risk Reduction of NSAID-Associated Gastric Ulcer PREVACID is indicated for reducing the risk of NSAID-associated gastric ulcers in patients with a history of a documented gastric ulcer who require the use of an NSAID. Controlled studies did not extend beyond 12 weeks. Gastroesophageal Reflux Disease (GERD) Short-Term Treatment of Symptomatic GERD PREVACID is indicated for the treatment of heartburn and other symptoms associated with GERD. Short-Term Treatment of Erosive Esophagitis PREVACID is indicated for short-term treatment (up to 8 weeks) for healing and symptom relief of all grades of erosive esophagitis. For patients who do not heal with PREVACID for 8 weeks (5-10%), it may be helpful to give an additional 8 weeks of treatment. If there is a recurrence of erosive esophagitis an additional 8-week course of PREVACID may be considered. Maintenance of Healing of Erosive Esophagitis PREVACID is indicated to maintain healing of erosive esophagitis. Controlled studies did not extend beyond 12 months. Pathological Hypersecretory Conditions Including Zollinger-Ellison Syndrome PREVACID is indicated for the long-term treatment of pathological hypersecretory conditions, including Zollinger-Ellison syndrome. Launch Date 1.03057922E12
Gastric ulcer 66 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2002/21-428lbl.pdf	Primary	Approved 8360	PREVACID Approved Use INDICATIONS AND USAGE. Short-Term Treatment of Active Duodenal Ulcer PREVACID is indicated for short-term treatment (up to 4 weeks) for healing and symptom relief of active duodenal ulcer. H. pylori Eradication to Reduce the Risk of Duodenal Ulcer Recurrence. Triple Therapy: PREVACID/amoxicillin/clarithromycin. PREVACID in combination with amoxicillin plus clarithromycin as triple therapy, is indicated for the treatment of patients with H. pylori infection and duodenal ulcer disease (active or one-year history of a duodenal ulcer) to eradicate H. pylori. Eradication of H. pylori has been shown to reduce the risk of duodenal ulcer recurrence. Dual Therapy: PREVACID/amoxicillin. PREVACID in combination with amoxicillin as dual therapy, is indicated for the treatment of patients with H. pylori infection and duodenal ulcer disease (active or one-year history of a duodenal ulcer) who are either allergic or intolerant to clarithromycin or in whom resistance to clarithromycin is known or suspected. Eradication of H. pylori has been shown to reduce the risk of duodenal ulcer recurrence. Maintenance of Healed Duodenal Ulcers PREVACID is indicated to maintain healing of duodenal ulcers. Controlled studies do not extend beyond 12 months. Short-Term Treatment of Active Benign Gastric Ulcer PREVACID is indicated for short-term treatment (up to 8 weeks) for healing and symptom relief of active benign gastric ulcer Healing of NSAID-Associated Gastric Ulcer PREVACID IS INDICATED FOR THE TREATMENT OF NSAID-ASSOCIATED GASTRIC ULCER IN PATIENTS WHO CONTINUE NSAID USE. CONTROLLED STUDIES DID NOT EXTEND BEYOND 8 WEEKS. Risk Reduction of NSAID-Associated Gastric Ulcer PREVACID is indicated for reducing the risk of NSAID-associated gastric ulcers in patients with a history of a documented gastric ulcer who require the use of an NSAID. Controlled studies did not extend beyond 12 weeks. Gastroesophageal Reflux Disease (GERD) Short-Term Treatment of Symptomatic GERD PREVACID is indicated for the treatment of heartburn and other symptoms associated with GERD. Short-Term Treatment of Erosive Esophagitis PREVACID is indicated for short-term treatment (up to 8 weeks) for healing and symptom relief of all grades of erosive esophagitis. For patients who do not heal with PREVACID for 8 weeks (5-10%), it may be helpful to give an additional 8 weeks of treatment. If there is a recurrence of erosive esophagitis an additional 8-week course of PREVACID may be considered. Maintenance of Healing of Erosive Esophagitis PREVACID is indicated to maintain healing of erosive esophagitis. Controlled studies did not extend beyond 12 months. Pathological Hypersecretory Conditions Including Zollinger-Ellison Syndrome PREVACID is indicated for the long-term treatment of pathological hypersecretory conditions, including Zollinger-Ellison syndrome. Launch Date 1.03057922E12
Gastroesophageal reflux disease 60 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2002/21-428lbl.pdf	Primary	Approved 8360	PREVACID Approved Use INDICATIONS AND USAGE. Short-Term Treatment of Active Duodenal Ulcer PREVACID is indicated for short-term treatment (up to 4 weeks) for healing and symptom relief of active duodenal ulcer. H. pylori Eradication to Reduce the Risk of Duodenal Ulcer Recurrence. Triple Therapy: PREVACID/amoxicillin/clarithromycin. PREVACID in combination with amoxicillin plus clarithromycin as triple therapy, is indicated for the treatment of patients with H. pylori infection and duodenal ulcer disease (active or one-year history of a duodenal ulcer) to eradicate H. pylori. Eradication of H. pylori has been shown to reduce the risk of duodenal ulcer recurrence. Dual Therapy: PREVACID/amoxicillin. PREVACID in combination with amoxicillin as dual therapy, is indicated for the treatment of patients with H. pylori infection and duodenal ulcer disease (active or one-year history of a duodenal ulcer) who are either allergic or intolerant to clarithromycin or in whom resistance to clarithromycin is known or suspected. Eradication of H. pylori has been shown to reduce the risk of duodenal ulcer recurrence. Maintenance of Healed Duodenal Ulcers PREVACID is indicated to maintain healing of duodenal ulcers. Controlled studies do not extend beyond 12 months. Short-Term Treatment of Active Benign Gastric Ulcer PREVACID is indicated for short-term treatment (up to 8 weeks) for healing and symptom relief of active benign gastric ulcer Healing of NSAID-Associated Gastric Ulcer PREVACID IS INDICATED FOR THE TREATMENT OF NSAID-ASSOCIATED GASTRIC ULCER IN PATIENTS WHO CONTINUE NSAID USE. CONTROLLED STUDIES DID NOT EXTEND BEYOND 8 WEEKS. Risk Reduction of NSAID-Associated Gastric Ulcer PREVACID is indicated for reducing the risk of NSAID-associated gastric ulcers in patients with a history of a documented gastric ulcer who require the use of an NSAID. Controlled studies did not extend beyond 12 weeks. Gastroesophageal Reflux Disease (GERD) Short-Term Treatment of Symptomatic GERD PREVACID is indicated for the treatment of heartburn and other symptoms associated with GERD. Short-Term Treatment of Erosive Esophagitis PREVACID is indicated for short-term treatment (up to 8 weeks) for healing and symptom relief of all grades of erosive esophagitis. For patients who do not heal with PREVACID for 8 weeks (5-10%), it may be helpful to give an additional 8 weeks of treatment. If there is a recurrence of erosive esophagitis an additional 8-week course of PREVACID may be considered. Maintenance of Healing of Erosive Esophagitis PREVACID is indicated to maintain healing of erosive esophagitis. Controlled studies did not extend beyond 12 months. Pathological Hypersecretory Conditions Including Zollinger-Ellison Syndrome PREVACID is indicated for the long-term treatment of pathological hypersecretory conditions, including Zollinger-Ellison syndrome. Launch Date 1.03057922E12

C_max

Value	Dose	Analyte	Population
1705 ng/mL DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/021566s005lbl.pdf	30 mg single, intravenous dose: 30 mg route of administration: Intravenous experiment type: SINGLE co-administered:	LANSOPRAZOLE plasma	Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
1136 ng/mL Clinical Trial https://clinicaltrials.gov/ct2/show/NCT00847210	60 mg 1 times / day multiple, oral dose: 60 mg route of administration: oral experiment type: multiple co-administered:	DEXLANSOPRAZOLE plasma	Homo sapiens population: unhealthy age: Adolescents sex: food status:
691 ng/mL Clinical Trial https://clinicaltrials.gov/ct2/show/NCT00847210	30 mg 1 times / day multiple, oral dose: 30 mg route of administration: oral experiment type: multiple co-administered:	DEXLANSOPRAZOLE plasma	Homo sapiens population: unhealthy age: Adolescents sex: food status:
16.1 (ng/mL)/mg Clinical Trial https://clinicaltrials.gov/ct2/show/NCT01045096	60 mg 1 times / day multiple, oral dose: 60 mg route of administration: oral experiment type: multiple co-administered:	DEXLANSOPRAZOLE plasma	Homo sapiens population: unhealthy age: Children sex: food status:
33.5 (ng/mL)/mg Clinical Trial https://clinicaltrials.gov/ct2/show/NCT01045096	30 mg 1 times / day multiple, oral dose: 30 mg route of administration: oral experiment type: multiple co-administered:	DEXLANSOPRAZOLE plasma	Homo sapiens population: unhealthy age: Children sex: food status:
37.3 (ng/mL)/mg Clinical Trial https://clinicaltrials.gov/ct2/show/NCT01045096	15 mg 1 times / day multiple, oral dose: 15 mg route of administration: oral experiment type: multiple co-administered:	DEXLANSOPRAZOLE plasma	Homo sapiens population: unhealthy age: Children sex: food status:
1005 ng/mL Clinical Trial https://clinicaltrials.gov/ct2/show/NCT01045096	30 mg 1 times / day multiple, oral dose: 30 mg route of administration: oral experiment type: multiple co-administered:	DEXLANSOPRAZOLE plasma	Homo sapiens population: unhealthy age: Children sex: food status:
559 ng/mL Clinical Trial https://clinicaltrials.gov/ct2/show/NCT01045096	15 mg 1 times / day multiple, oral dose: 15 mg route of administration: oral experiment type: multiple co-administered:	DEXLANSOPRAZOLE plasma	Homo sapiens population: unhealthy age: Children sex: food status:
964 ng/mL Clinical Trial https://clinicaltrials.gov/ct2/show/NCT01045096	60 mg 1 times / day multiple, oral dose: 60 mg route of administration: oral experiment type: multiple co-administered:	DEXLANSOPRAZOLE plasma	Homo sapiens population: unhealthy age: Children sex: food status:
658 ng/mL DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/022287s031lbl.pdf	30 mg 1 times / day multiple, oral dose: 30 mg route of administration: Oral experiment type: MULTIPLE co-administered:	DEXLANSOPRAZOLE plasma	Homo sapiens population: HEALTHY age: UNKNOWN sex: UNKNOWN food status: UNKNOWN
1397 ng/mL DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/022287s031lbl.pdf	60 mg 1 times / day multiple, oral dose: 60 mg route of administration: Oral experiment type: MULTIPLE co-administered:	DEXLANSOPRAZOLE plasma	Homo sapiens population: HEALTHY age: UNKNOWN sex: UNKNOWN food status: UNKNOWN

AUC

Value	Dose	Analyte	Population
3192 ng × h/mL DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/021566s005lbl.pdf	30 mg single, intravenous dose: 30 mg route of administration: Intravenous experiment type: SINGLE co-administered:	LANSOPRAZOLE plasma	Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
143.2 (ng*h/mL)/mg Clinical Trial https://clinicaltrials.gov/ct2/show/NCT01045096	15 mg 1 times / day multiple, oral dose: 15 mg route of administration: oral experiment type: multiple co-administered:	DEXLANSOPRAZOLE plasma	Homo sapiens population: unhealthy age: Children sex: food status:
55.5 (ng*h/mL)/mg Clinical Trial https://clinicaltrials.gov/ct2/show/NCT01045096	60 mg 1 times / day multiple, oral dose: 60 mg route of administration: oral experiment type: multiple co-administered:	DEXLANSOPRAZOLE plasma	Homo sapiens population: unhealthy age: Children sex: food status:
87.6 (ng*h/mL)/mg Clinical Trial https://clinicaltrials.gov/ct2/show/NCT01045096	30 mg 1 times / day multiple, oral dose: 30 mg route of administration: oral experiment type: multiple co-administered:	DEXLANSOPRAZOLE plasma	Homo sapiens population: unhealthy age: Children sex: food status:
2149 ng*h/mL Clinical Trial https://clinicaltrials.gov/ct2/show/NCT01045096	15 mg 1 times / day multiple, oral dose: 15 mg route of administration: oral experiment type: multiple co-administered:	DEXLANSOPRAZOLE plasma	Homo sapiens population: unhealthy age: Children sex: food status:
2628 ng*h/mL Clinical Trial https://clinicaltrials.gov/ct2/show/NCT01045096	30 mg 1 times / day multiple, oral dose: 30 mg route of administration: oral experiment type: multiple co-administered:	DEXLANSOPRAZOLE plasma	Homo sapiens population: unhealthy age: Children sex: food status:
3330 ng*h/mL Clinical Trial https://clinicaltrials.gov/ct2/show/NCT01045096	60 mg 1 times / day multiple, oral dose: 60 mg route of administration: oral experiment type: multiple co-administered:	DEXLANSOPRAZOLE plasma	Homo sapiens population: unhealthy age: Children sex: food status:
128 (ng*h/mL)/mg Clinical Trial https://clinicaltrials.gov/ct2/show/NCT01045096	15 mg 1 times / day multiple, oral dose: 15 mg route of administration: oral experiment type: multiple co-administered:	DEXLANSOPRAZOLE plasma	Homo sapiens population: unhealthy age: Children sex: food status:
62 (ng*h/mL)/mg Clinical Trial https://clinicaltrials.gov/ct2/show/NCT01045096	60 mg 1 times / day multiple, oral dose: 60 mg route of administration: oral experiment type: multiple co-administered:	DEXLANSOPRAZOLE plasma	Homo sapiens population: unhealthy age: Children sex: food status:
96 (ng*h/mL)/mg Clinical Trial https://clinicaltrials.gov/ct2/show/NCT01045096	30 mg 1 times / day multiple, oral dose: 30 mg route of administration: oral experiment type: multiple co-administered:	DEXLANSOPRAZOLE plasma	Homo sapiens population: unhealthy age: Children sex: food status:
1914 ng*h/mL Clinical Trial https://clinicaltrials.gov/ct2/show/NCT01045096	15 mg 1 times / day multiple, oral dose: 15 mg route of administration: oral experiment type: multiple co-administered:	DEXLANSOPRAZOLE plasma	Homo sapiens population: unhealthy age: Children sex: food status:
2892 ng*h/mL Clinical Trial https://clinicaltrials.gov/ct2/show/NCT01045096	30 mg 1 times / day multiple, oral dose: 30 mg route of administration: oral experiment type: multiple co-administered:	DEXLANSOPRAZOLE plasma	Homo sapiens population: unhealthy age: Children sex: food status:
3747 ng*h/mL Clinical Trial https://clinicaltrials.gov/ct2/show/NCT01045096	60 mg 1 times / day multiple, oral dose: 60 mg route of administration: oral experiment type: multiple co-administered:	DEXLANSOPRAZOLE plasma	Homo sapiens population: unhealthy age: Children sex: food status:
3275 ng × h/mL DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/022287s031lbl.pdf	30 mg 1 times / day multiple, oral dose: 30 mg route of administration: Oral experiment type: MULTIPLE co-administered:	DEXLANSOPRAZOLE plasma	Homo sapiens population: HEALTHY age: UNKNOWN sex: UNKNOWN food status: UNKNOWN
6529 ng × h/mL DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/022287s031lbl.pdf	60 mg 1 times / day multiple, oral dose: 60 mg route of administration: Oral experiment type: MULTIPLE co-administered:	DEXLANSOPRAZOLE plasma	Homo sapiens population: HEALTHY age: UNKNOWN sex: UNKNOWN food status: UNKNOWN

T_1/2

Value	Dose	Analyte	Population
1.3 h DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/021566s005lbl.pdf	30 mg single, intravenous dose: 30 mg route of administration: Intravenous experiment type: SINGLE co-administered:	LANSOPRAZOLE plasma	Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
2.59 h Clinical Trial https://clinicaltrials.gov/ct2/show/NCT00847210	60 mg 1 times / day multiple, oral dose: 60 mg route of administration: oral experiment type: multiple co-administered:	DEXLANSOPRAZOLE plasma	Homo sapiens population: unhealthy age: Adolescents sex: food status:
1.66 h Clinical Trial https://clinicaltrials.gov/ct2/show/NCT00847210	30 mg 1 times / day multiple, oral dose: 30 mg route of administration: oral experiment type: multiple co-administered:	DEXLANSOPRAZOLE plasma	Homo sapiens population: unhealthy age: Adolescents sex: food status:

Doses

Dose	Population	Adverse events
30 mg 2 times / day multiple, intravenous Dose: 30 mg, 2 times / day Route: intravenous Route: multiple Dose: 30 mg, 2 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/28138748	healthy, 18-29 years n = 18 Health Status: healthy Age Group: 18-29 years Sex: M+F Population Size: 18 Sources: https://pubmed.ncbi.nlm.nih.gov/28138748	Sources: https://pubmed.ncbi.nlm.nih.gov/28138748
90 mg single, intravenous Dose: 90 mg Route: intravenous Route: single Dose: 90 mg Sources: https://pubmed.ncbi.nlm.nih.gov/28138748	healthy, 18-29 years n = 8 Health Status: healthy Age Group: 18-29 years Sex: M+F Population Size: 8 Sources: https://pubmed.ncbi.nlm.nih.gov/28138748	Sources: https://pubmed.ncbi.nlm.nih.gov/28138748
300 mg single, oral Highest studied dose Dose: 300 mg Route: oral Route: single Dose: 300 mg Sources: https://pubmed.ncbi.nlm.nih.gov/19826060	healthy, 35 years (range: 18 - 50 years) n = 36 Health Status: healthy Age Group: 35 years (range: 18 - 50 years) Sex: M+F Population Size: 36 Sources: https://pubmed.ncbi.nlm.nih.gov/19826060	Sources: https://pubmed.ncbi.nlm.nih.gov/19826060
60 mg 1 times / day steady, oral Recommended Dose: 60 mg, 1 times / day Route: oral Route: steady Dose: 60 mg, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208056lbl.pdf https://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022287s000_MedR_P1.pdf	unhealthy, 48 years (range: 18-90 years) n = 2218 Health Status: unhealthy Age Group: 48 years (range: 18-90 years) Sex: M+F Population Size: 2218 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208056lbl.pdf https://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022287s000_MedR_P1.pdf	Disc. AE: Diarrhea... AEs leading to discontinuation/dose reduction: Diarrhea (0.7%) Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208056lbl.pdf https://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022287s000_MedR_P1.pdf
60 mg 1 times / day steady, oral Recommended Dose: 60 mg, 1 times / day Route: oral Route: steady Dose: 60 mg, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022287s000_MedR_P1.pdf Page: p. 35	unhealthy, 48 years (range: 18-90 years) n = 2218 Health Status: unhealthy Age Group: 48 years (range: 18-90 years) Sex: M+F Population Size: 2218 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022287s000_MedR_P1.pdf Page: p. 35	Disc. AE: Abdominal pain... AEs leading to discontinuation/dose reduction: Abdominal pain (0.5%) Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022287s000_MedR_P1.pdf Page: p. 35
30 mg 1 times / day steady, oral Dose: 30 mg, 1 times / day Route: oral Route: steady Dose: 30 mg, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022287s000_MedR_P1.pdf Page: p. 35	unhealthy, 48 years (range: 18-90 years) n = 455 Health Status: unhealthy Age Group: 48 years (range: 18-90 years) Sex: M+F Population Size: 455 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022287s000_MedR_P1.pdf Page: p. 35	Disc. AE: Diarrhea... AEs leading to discontinuation/dose reduction: Diarrhea (0.2%) Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022287s000_MedR_P1.pdf Page: p. 35
90 mg 1 times / day steady, oral Dose: 90 mg, 1 times / day Route: oral Route: steady Dose: 90 mg, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022287s000_MedR_P1.pdf Page: p. 35	unhealthy, 48 years (range: 18-90 years) n = 1754 Health Status: unhealthy Age Group: 48 years (range: 18-90 years) Sex: M+F Population Size: 1754 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022287s000_MedR_P1.pdf Page: p. 35	Disc. AE: Diarrhea, Abdominal pain... AEs leading to discontinuation/dose reduction: Diarrhea (0.7%) Abdominal pain (0.6%) Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022287s000_MedR_P1.pdf Page: p. 35
60 mg 1 times / day steady, oral Recommended Dose: 60 mg, 1 times / day Route: oral Route: steady Dose: 60 mg, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022287s000_MedR_P1.pdf Page: p. 36	unhealthy, adult n = 2311 Health Status: unhealthy Age Group: adult Population Size: 2311 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022287s000_MedR_P1.pdf Page: p. 36	Disc. AE: Dyspepsia, Eructation... AEs leading to discontinuation/dose reduction: Dyspepsia (3 patients) Eructation (2 patients) Nausea (6 patients) Vomiting (6 patients) Erosive esophagitis (1 patient) Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022287s000_MedR_P1.pdf Page: p. 36
90 mg 1 times / day steady, oral Dose: 90 mg, 1 times / day Route: oral Route: steady Dose: 90 mg, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022287s000_MedR_P1.pdf Page: p. 36	unhealthy, adult n = 2142 Health Status: unhealthy Age Group: adult Population Size: 2142 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022287s000_MedR_P1.pdf Page: p. 36	Disc. AE: Dyspepsia, Eructation... AEs leading to discontinuation/dose reduction: Dyspepsia (1 patient) Eructation (1 patient) Nausea (9 patients) Vomiting (6 patients) Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022287s000_MedR_P1.pdf Page: p. 36
60 mg 2 times / day steady, oral Overdose Dose: 60 mg, 2 times / day Route: oral Route: steady Dose: 60 mg, 2 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208056lbl.pdf	unhealthy Health Status: unhealthy Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208056lbl.pdf	Other AEs: Hypertension... Other AEs: Hypertension (serious) Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208056lbl.pdf

AEs

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
substrate 1709 inhibitor 1579	inhibitor 1752	inhibitor 1837

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
CYP1A1 110 CYP1A2 1509 CYP2A6 704 CYP2B6 799 CYP2C8 901 CYP2E1 876 CYP2C19 1463	CYP2C19 985

Drug as perpetrator

Target	Modality	Activity	Clinical evidence
CYP1A1 218	inhibitor 3240 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/022287s019lbl.pdf#page=11 Page: 11.0	unlikely
CYP2A6 736	inhibitor 3240 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/022287s019lbl.pdf#page=13 Page: 11.0	unlikely
CYP2B6 985	inhibitor 3240 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/022287s019lbl.pdf#page=14 Page: 11.0	unlikely
CYP2C8 955	inhibitor 3240 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/022287s019lbl.pdf#page=15 Page: 11.0	unlikely
CYP2D6 1875	inhibitor 3240 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/022287s019lbl.pdf#page=17 Page: 11.0	unlikely
CYP2E1 964	inhibitor 3240 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/022287s019lbl.pdf#page=18 Page: 11.0	unlikely
CYP3A4 1909	inhibitor 3240 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/022287s019lbl.pdf#page=19 Page: 11.0	unlikely
CYP1A2 1673	inhibitor 3240 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/022287s019lbl.pdf#page=12 Page: 11.0	unlikely	no (co-administration study) Comment: in vivo studies showed that DEXILANT did not have an impact on the pharmacokinetics of coadministered theophylline (CYP1A2 substrate) Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/022287s019lbl.pdf#page=12 Page: 11.0
CYP2C9 1803	inhibitor 3240 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/022287s019lbl.pdf#page=16 Page: 11.0	unlikely	no (co-administration study) Comment: in vivo studies showed that DEXILANT did not have an impact on the pharmacokinetics of coadministered phenytoin (CYP2C9 substrate) Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/022287s019lbl.pdf#page=16 Page: 11.0
CYP2C19 1537	inhibitor 3240 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/022287s019lbl.pdf#page=19#page=12; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930293/#:~:text=Metabolism,and%2048%25%20in%20the%20feces.&text=No%20dose%20adjustments%20are%20needed,impairment%20or%20mild%20hepatic%20impairment.	weak	unknown (co-administration study) Comment: The mean AUC of the active metabolite of clopidogrel was reduced by approximately 9% (mean AUC ratio was 91%, with 90% CI of 86- 97%) Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/022287s019lbl.pdf#page=19#page=12; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930293/#:~:text=Metabolism,and%2048%25%20in%20the%20feces.&text=No%20dose%20adjustments%20are%20needed,impairment%20or%20mild%20hepatic%20impairment.

Drug as victim

Target	Modality	Activity	Metabolite	Clinical evidence
CYP3A4 1709	substrate 3326 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/022287s019lbl.pdf#page=10 Page: 10.0	yes
CYP2C19 985	substrate 3326 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/022287s019lbl.pdf#page=10 Page: 10,12	yes		yes (pharmacogenomic study) Comment: mean dexlansoprazole Cmax and AUC values were up to 2 times higher in intermediate compared to extensive metabolizers; in poor metabolizers, mean Cmax was up to 4 times higher and mean AUC was up to 12 times higher compared to extensive metabolizers Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/022287s019lbl.pdf#page=10 Page: 10,12

Sourcing

Vendor/Aggregator	ID	URL
001 Chemical	DY521004	https://www.001chemical.com/chem/138530-94-6
AEchem Scientific Corp., USA	AE047759	http://www.aechemsc.com/info_products/AE047759.php
AK Scientific, Inc. (AKSCI)	W0028	http://www.aksci.com/item_detail.php?cat=W0028
AbMole Bioscience	M2627	http://www.abmole.com/products/dexlansoprazole.html
Aceschem	ACF021692	https://www.aceschem.com/catalog/138530-94-6.html
Achemo Scientific Limited	AC-74368	http://www.achemo.com/search/?Keyword= 138530-94-6
Acorn PharmaTech	ACN-046381	http://www.acornpharmatech.com/
Alsachim	890	http://www.alsachim.com/product-C1208-glo.bal-view.html
Ambinter	Amb2444038	http://www.ambinter.com/reference/2444038
Ark Pharm	AK170558	http://www.arkpharminc.com/products/138530-94-6.html
Aurum Pharmatech LLC	Q-1374	http://www.Aurumpharmatech.com/Product/ProductDetails/Q_1374
ChEBI	CHEBI:6375	https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:6375
Chem Scene	CS-2820	http://www.chemscene.com/138530-94-6.html
ChemMol	49420692	http://www.chemmol.com/chemmol/49420692.html
ChemMol	99043051	http://www.chemmol.com/chemmol/99043051.html
Chemenu	CM106762	http://www.chemenu.com/products/CM106762
ChemicalBook	CB6396972	https://www.chemicalbook.com/ChemicalProductProperty_EN_CB6396972
Chemspace	CSSB00016993951	https://chem-space.com/CSSB00016993951
Combi-Blocks	QC-7636	http://www.combi-blocks.com/cgi-bin/find.cgi?QC-7636
DC Chemicals	DC9092	http://www.dcchemicals.com/product_show-_R_Lansoprazole.html
Hairui	HR111133	http://www.hairuichem.com/en/product/138530-94-6.html
Lab Network	LN01349254	https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN01349254
MedChem Express	HY-13662B	https://www.medchemexpress.com/_R_-Lansoprazole.html
MolPort	MolPort-003-666-508	https://www.molport.com/shop/molecule-link/MolPort-003-666-508
Molcore	MC521004	https://www.molcore.com/product/138530-94-6
Selleck Chemicals	Lansoprazole	http://www.selleckchem.com/products/Lansoprazole.html
Smolecule	S525777	http://www.smolecule.com/products/s525777
Synblock Inc	PB33188	http://www.synblock.com/product/138530-94-6.html
THE BioTek	bt-267370	https://www.thebiotek.com/product/inhibitors/bt-267370
abcr GmbH	AB455993	http://www.abcr.com/shop/en/AB455993
eMolecules	902018	https://www.emolecules.com/cgi-bin/more?vid=902018
eNovation Chemicals	D588547	https://www.enovationchem.com/ProductDetails.asp?ProductID=D588547
eNovation Chemicals	D676423	https://www.enovationchem.com/ProductDetails.asp?ProductID=D676423
eNovation Chemicals	D762688	https://www.enovationchem.com/ProductDetails.asp?ProductID=D762688
iChemical	EBD14854	http://www.ichemical.com/products/138530-94-6.html?utm_source=PubChem&utm_medium=website&utm_campaign=product%20catalogs

PubMed

Title	Date	PubMed
The treatment of gastroesophageal reflux disease with proton-pump inhibitors and its implications on managed care--pharmacoeconomics and its application to antisecretory drugs: a case study.	2001	11569296
Advantage of expressing the variations in some digestive parameters as a function of gastric emptying instead of time.	2001	11549836
[The effectiveness of 7-day combined Helicobacter eradication therapy in patients with peptic ulcer and chronic gastritis].	2001	11521379
Effects of lansoprazole on human gastric lipase secretion and intragastric lipolysis in healthy human volunteers.	2001	11435719
Hyposecretion of the adrenal androgen dehydroepiandrosterone sulfate and its relation to clinical variables in inflammatory arthritis.	2001	11299059
Lansoprazole treatment of patients with chronic idiopathic laryngitis: a placebo-controlled trial.	2001 Apr	11316215
Intragastric acidification reduces the occurrence of false-negative urea breath test results in patients taking a proton pump inhibitor.	2001 Apr	11316142
[H2 receptor antagonists and proton pump inhibitors: principles and rules of use].	2001 Apr 15	11387678
[A strategy for second-line anti-Helicobacter pylori therapy in patients with previously failed treatment].	2001 Feb	11218406
Current approaches to reducing gastrointestinal toxicity of low-dose aspirin.	2001 Jan 8	11166003
Factors affecting Helicobacter pylori eradication using a seven-day triple therapy with a proton pump inhibitor, tinidazole and clarithromycin, in Brazilian patients with peptic ulcer.	2001 Jan-Feb	11378678
Inhibition of hyphal growth of Candida albicans by activated lansoprazole, a novel benzimidazole proton pump inhibitor.	2001 Jun	11446532
Helicobacter pylori and early duodenal ulcer status post-treatment: a review.	2001 Jun	11422462
Treatment of gastroesophageal reflux disease: to step or not to step.	2001 Jun	11419813
Proton pump inhibitors: a study of GPs' prescribing.	2001 Jun	11356744
Helicobacter pylori and symptomatic relapse of gastro-oesophageal reflux disease: a randomised controlled trial.	2001 Jun 2	11403809
Gastroprotective effect of aparisthman, a diterpene isolated from Aparisthmium cordatum, on experimental gastric ulcer models in rats and mice.	2001 Mar	11315762
Acetaldehyde production and other ADH-related characteristics of aerobic bacteria isolated from hypochlorhydric human stomach.	2001 Mar	11290854
Bioequivalence evaluation of lansoprazole 30-mg capsules (Lanfast and Lanzor) in healthy volunteers.	2001 Mar	11226823
[Gynecomastia associated with the simultaneous use of cisapride and lansoprazole].	2001 Mar 24	11333695
Shortcomings of the first-generation proton pump inhibitors.	2001 May	11430506
Impact of different therapeutic regimens on the outcome of patients with Crohn's disease of the upper gastrointestinal tract.	2001 May	11383598
Review article: long-term use of proton pump inhibitors in GORD--help or hindrance?	2001 Sep	11556874
Lansoprazole in children: pharmacokinetics and efficacy in reflux oesophagitis.	2001 Sep	11552911
Bedtime H2 blockers improve nocturnal gastric acid control in GERD patients on proton pump inhibitors.	2001 Sep	11552905
Noninvasive Helicobacter pylori testing for the "test-and-treat" strategy: a decision analysis to assess the effect of past infection on test choice.	2001 Sep 24	11570943
[New triple therapy for Helicobacter pylori infection in Japan].	2003 Jan	12607326
Safety and pharmacokinetics of oral lansoprazole in preadolescent rats exposed from weaning through sexual maturity.	2003 Jan-Feb	12507665
Does eradication of Helicobacter pylori reduce hypergastrinaemia during long term therapy with proton pump inhibitors?	2003 Mar	12762431
Flavor and taste of lansoprazole strawberry-flavored delayed-release oral suspension preferred over ranitidine peppermint-flavored oral syrup: in children aged between 5-11 years.	2004	15035653
Effect of lansoprazole and rabeprazole on tacrolimus pharmacokinetics in healthy volunteers with CYP2C19 mutations.	2004 Aug	15285851
Drug-induced tubulo-interstitial nephritis secondary to proton pump inhibitors: experience from a single UK renal unit.	2004 Jun	15004262
Lansoprazole ameliorates intestinal mucosal damage induced by ischemia-reperfusion in rats.	2004 Oct 1	15334676
Management of acid-related disorders in patients with dysphagia.	2004 Sep 6	15478852
Hyponatremia with consciousness disturbance associated with esomeprazole.	2005 Apr	15741423
Prediction of genotoxicity of chemical compounds by statistical learning methods.	2005 Jun	15962942
Preventive therapy for non-steroidal anti-inflammatory drug-induced ulcers in Japanese patients with rheumatoid arthritis: the current situation and a prospective controlled-study of the preventive effects of lansoprazole or famotidine.	2005 Jun	15943850
Comparison of enantioselective disposition of rabeprazole versus lansoprazole in renal-transplant recipients who are CYP2C19 extensive metabolizers.	2005 May	16012079
"Proton-pump inhibitor-first" strategy versus "step-up" strategy for the acute treatment of reflux esophagitis: a cost-effectiveness analysis in Japan.	2005 Nov	16322946
Helicobacter pylori infection with a duodenal ulcer in a 6-year-old boy.	2006 Oct	17106182
Lack of pharmacokinetic interaction between omeprazole or lansoprazole and ivabradine in healthy volunteers: an open-label, randomized, crossover, pharmacokinetic interaction clinical trial.	2006 Oct	16988209
Functional involvement of PHOSPHO1 in matrix vesicle-mediated skeletal mineralization.	2007 Apr	17227223
Protective effects of proton pump inhibitors against indomethacin-induced lesions in the rat small intestine.	2007 Jan	17151854
Antiulcerogenic effect and acute toxicity of a hydroethanolic extract from the cashew (Anacardium occidentale L.) leaves.	2007 Jun 13	17499463
Influence of H pylori on plasma ghrelin in patients without atrophic gastritis.	2007 Mar 14	17461454
Influence of rabeprazole and lansoprazole on the pharmacokinetics of tacrolimus in relation to CYP2C19, CYP3A5 and MDR1 polymorphisms in renal transplant recipients.	2007 May	17377957
Lansoprazole protects and heals gastric mucosa from non-steroidal anti-inflammatory drug (NSAID)-induced gastropathy by inhibiting mitochondrial as well as Fas-mediated death pathways with concurrent induction of mucosal cell renewal.	2008 May 23	18375387
Delayed release dexlansoprazole in the treatment of GERD and erosive esophagitis.	2009	21694835
Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development.	2009	19515014
New insights into the structural features and functional relevance of human cytochrome P450 2C9. Part II.	2009 Dec	20167000

Patents

Sample Use Guides

In Vivo Use Guide

For erosive esophagitis: One 60 mg capsule once daily for up to 8 weeks Relief of Heartburn: One 30 mg capsule once daily

Route of Administration: Oral

In Vitro Use Guide

A stably transfected gene reporter cell line AZ-AHR, derived from human hepatoma HepG2 cells transfected with a construct containing several AhR binding sites upstream of a luciferase reporter gene, was used for assessment of AhR transcriptional activity. Cells were incubated for 24 h with DEXLANSOPRAZOLE and/or vehicle (DMSO; 0.1% v/v), in the presence or absence of TCDD (10 nM; AZ-AHR cells) or DEX (100 nM; AZ-GR cells). After the treatments, cells were lysed and luciferase activity was measured. In parallel, cell viability was determined by conventional MTT test.

Name

Type

Language

LANSOPRAZOLE

Official Name

English

LANSOPRAZOLE [MI]

Common Name

English

LANZOR

Brand Name

English

AG-1749

Code

English

LANSOPRAZOLE [ORANGE BOOK]

Common Name

English

2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]benzimidazole

Systematic Name

English

LANSOPRAZOLE COMPONENT OF PREVPAC

Common Name

English

LANSOPRAZOLE [USP MONOGRAPH]

Common Name

English

PREVACID

Brand Name

English

PREVPAC COMPONENT LANSOPRAZOLE

Brand Name

English

TAKEPRON

Brand Name

English

2-(((3-METHYL-4-(2,2,2-TRIFLUOROETHOXY)PYRIDIN-2-YL)METHYL)SULFINYL)-1H-BENZIMIDAZOLE

Systematic Name

English

Lansoprazole [WHO-DD]

Common Name

English

A-65006

Code

English

LANSOPRAZOLE [EP MONOGRAPH]

Common Name

English

LANZOPRAZOLE

Common Name

English

AGOPTON

Brand Name

English

lansoprazole [INN]

Common Name

English

(±)-LANSOPRAZOLE

Common Name

English

PREVONCO

Brand Name

English

NSC-758638

Code

English

LANSOX

Brand Name

English

LANSOPRAZOLE [USP-RS]

Common Name

English

LIMPIDEX

Brand Name

English

LANSOPRAZOLE [HSDB]

Common Name

English

LANSOPRAZOLE [JAN]

Common Name

English

LANSOPRAZOLE [MART.]

Common Name

English

1H-BENZIMIDAZOLE, 2-(((3-METHYL-4-(2,2,2-TRIFLUOROETHOXY)-2-PYRIDINYL)METHYL)SULFINYL)-

Systematic Name

English

OGAST

Brand Name

English

ZOTON

Brand Name

English

OGASTORO

Brand Name

English

LANSOPRAZOLE [VANDF]

Common Name

English

LANSOPRAZOLE [USAN]

Common Name

English

Classification Tree Code System Code

WHO-ATC

A02BC03