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US Approved Rx

8

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Primary Target

Potassium-transporting ATPase

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Highest Phase

Approved

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Approval Year

1989

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1995

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Condition

Gastric ulcer

8

Gastroesophageal reflux disease

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Active duodenal ulcer

6

Erosive esophagitis

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Heartburn

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Treatment Modality

Primary

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Curative

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CNS Activity

CNS Active

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CNS Penetrant

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Originator

Takeda Chemical Industries

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Chemical

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CAS

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EPA CompTox

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ATC Level 1

ALIMENTARY TRACT AND METABOLISM

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ATC Level 2

DRUGS FOR ACID RELATED DISORDERS

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ATC Level 3

DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)

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ATC Level 4

Proton pump inhibitors

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Combinations for eradication of Helicobacter pylori

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Salts, Hydrates, Esters, etc.

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Showing 1 - 8 of 8 results

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LANSOPRAZOLE

0K5C5T2QPG

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Status:

US Approved Rx (2017)

First approved in 1995

Class (Stereo):

CHEMICAL (RACEMIC)

Targets:

Potassium-transporting ATPase

Potassium-transporting ATPase

Potassium-transporting ATPase

Conditions:

Active duodenal ulcer

Gastroesophageal reflux disease

Gastroesophageal reflux disease

Active duodenal ulcer

Erosive esophagitis

Dexlansoprazole (trade names Kapidex, Dexilant) is a proton pump inhibitor (PPI) that is marketed by Takeda Pharmaceuticals for the treatment of erosive esophagitis and gastro-oesophageal reflux disease. Dexlansoprazole is used to heal and maintain h...

ealing of erosive esophagitis and to treat heartburn associated with gastroesophageal reflux disease (GERD). It lasts longer than lansoprazole, to which it is chemically related, and needs to be taken less often. Dexlansoprazole is supplied for oral administration as a dual delayed-release formulation in capsules and orally disintegrating tablets. The capsules and tablets contain dexlansoprazole in a mixture of two types of enteric-coated granules with different pH-dependent dissolution profiles. The most significant adverse reactions (≥2%) reported in clinical trials were diarrhea, abdominal pain, nausea, upper respiratory tract infection, vomiting, and flatulence.

OMEPRAZOLE SODIUM

KV03YZ6QLW

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Status:

US Approved Rx (2016)

First approved in 1989

Class (Stereo):

CHEMICAL (RACEMIC)

Targets:

Potassium-transporting ATPase

Conditions:

Gastroesophageal reflux disease

Pathological hypersecretory conditions

Esomeprazole strontium is a proton pump inhibitor. It suppresses gastric acid secretion by specific inhibition H+/K+ ATPase in the gastric parietal cell. The S- and R-isomers of omeprazole are protonated and converted in the acidic compartment of the...

parietal cell forming the active inhibitor, the achiral sulphenamide. By acting specifically on the proton pump, esomeprazole blocks the final step in acid production, thus reducing gastric acidity. The drug is indicated for the treatment of gastroesophageal reflux disease, reduction the risk of NSAID-associated gastric ulcer, eradication of H.pylori, and pathological hypersecretory conditions.

AG-2000 FREE BASE

7EMR32786O

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Status:

US Approved Rx (2017)

First approved in 1995

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Potassium-transporting ATPase

Potassium-transporting ATPase

Potassium-transporting ATPase

Conditions:

Active duodenal ulcer

Gastroesophageal reflux disease

Gastroesophageal reflux disease

Active duodenal ulcer

Erosive esophagitis

Dexlansoprazole (trade names Kapidex, Dexilant) is a proton pump inhibitor (PPI) that is marketed by Takeda Pharmaceuticals for the treatment of erosive esophagitis and gastro-oesophageal reflux disease. Dexlansoprazole is used to heal and maintain h...

ealing of erosive esophagitis and to treat heartburn associated with gastroesophageal reflux disease (GERD). It lasts longer than lansoprazole, to which it is chemically related, and needs to be taken less often. Dexlansoprazole is supplied for oral administration as a dual delayed-release formulation in capsules and orally disintegrating tablets. The capsules and tablets contain dexlansoprazole in a mixture of two types of enteric-coated granules with different pH-dependent dissolution profiles. The most significant adverse reactions (≥2%) reported in clinical trials were diarrhea, abdominal pain, nausea, upper respiratory tract infection, vomiting, and flatulence.

LEVOLANSOPRAZOLE

FB55O16184

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Status:

US Approved Rx (2017)

First approved in 1995

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Potassium-transporting ATPase

Potassium-transporting ATPase

Potassium-transporting ATPase

Conditions:

Active duodenal ulcer

Gastroesophageal reflux disease

Gastroesophageal reflux disease

Active duodenal ulcer

Erosive esophagitis

Dexlansoprazole (trade names Kapidex, Dexilant) is a proton pump inhibitor (PPI) that is marketed by Takeda Pharmaceuticals for the treatment of erosive esophagitis and gastro-oesophageal reflux disease. Dexlansoprazole is used to heal and maintain h...

ealing of erosive esophagitis and to treat heartburn associated with gastroesophageal reflux disease (GERD). It lasts longer than lansoprazole, to which it is chemically related, and needs to be taken less often. Dexlansoprazole is supplied for oral administration as a dual delayed-release formulation in capsules and orally disintegrating tablets. The capsules and tablets contain dexlansoprazole in a mixture of two types of enteric-coated granules with different pH-dependent dissolution profiles. The most significant adverse reactions (≥2%) reported in clinical trials were diarrhea, abdominal pain, nausea, upper respiratory tract infection, vomiting, and flatulence.

DEXLANSOPRAZOLE SESQUIHYDRATE

HS2S9VK3NH

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Status:

US Approved Rx (2017)

First approved in 1995

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Potassium-transporting ATPase

Potassium-transporting ATPase

Potassium-transporting ATPase

Conditions:

Active duodenal ulcer

Gastroesophageal reflux disease

Gastroesophageal reflux disease

Active duodenal ulcer

Erosive esophagitis

Dexlansoprazole (trade names Kapidex, Dexilant) is a proton pump inhibitor (PPI) that is marketed by Takeda Pharmaceuticals for the treatment of erosive esophagitis and gastro-oesophageal reflux disease. Dexlansoprazole is used to heal and maintain h...

ealing of erosive esophagitis and to treat heartburn associated with gastroesophageal reflux disease (GERD). It lasts longer than lansoprazole, to which it is chemically related, and needs to be taken less often. Dexlansoprazole is supplied for oral administration as a dual delayed-release formulation in capsules and orally disintegrating tablets. The capsules and tablets contain dexlansoprazole in a mixture of two types of enteric-coated granules with different pH-dependent dissolution profiles. The most significant adverse reactions (≥2%) reported in clinical trials were diarrhea, abdominal pain, nausea, upper respiratory tract infection, vomiting, and flatulence.

LANSOPRAZOLE SODIUM

GV9NY1U369

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Status:

US Approved Rx (2017)

First approved in 1995

Class (Stereo):

CHEMICAL (RACEMIC)

Targets:

Potassium-transporting ATPase

Potassium-transporting ATPase

Potassium-transporting ATPase

Conditions:

Active duodenal ulcer

Gastroesophageal reflux disease

Gastroesophageal reflux disease

Active duodenal ulcer

Erosive esophagitis

Dexlansoprazole (trade names Kapidex, Dexilant) is a proton pump inhibitor (PPI) that is marketed by Takeda Pharmaceuticals for the treatment of erosive esophagitis and gastro-oesophageal reflux disease. Dexlansoprazole is used to heal and maintain h...

ealing of erosive esophagitis and to treat heartburn associated with gastroesophageal reflux disease (GERD). It lasts longer than lansoprazole, to which it is chemically related, and needs to be taken less often. Dexlansoprazole is supplied for oral administration as a dual delayed-release formulation in capsules and orally disintegrating tablets. The capsules and tablets contain dexlansoprazole in a mixture of two types of enteric-coated granules with different pH-dependent dissolution profiles. The most significant adverse reactions (≥2%) reported in clinical trials were diarrhea, abdominal pain, nausea, upper respiratory tract infection, vomiting, and flatulence.

DEXLANSOPRAZOLE

UYE4T5I70X

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Status:

US Approved Rx (2017)

First approved in 1995

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Potassium-transporting ATPase

Potassium-transporting ATPase

Potassium-transporting ATPase

Conditions:

Active duodenal ulcer

Gastroesophageal reflux disease

Gastroesophageal reflux disease

Active duodenal ulcer

Erosive esophagitis

Dexlansoprazole (trade names Kapidex, Dexilant) is a proton pump inhibitor (PPI) that is marketed by Takeda Pharmaceuticals for the treatment of erosive esophagitis and gastro-oesophageal reflux disease. Dexlansoprazole is used to heal and maintain h...

ealing of erosive esophagitis and to treat heartburn associated with gastroesophageal reflux disease (GERD). It lasts longer than lansoprazole, to which it is chemically related, and needs to be taken less often. Dexlansoprazole is supplied for oral administration as a dual delayed-release formulation in capsules and orally disintegrating tablets. The capsules and tablets contain dexlansoprazole in a mixture of two types of enteric-coated granules with different pH-dependent dissolution profiles. The most significant adverse reactions (≥2%) reported in clinical trials were diarrhea, abdominal pain, nausea, upper respiratory tract infection, vomiting, and flatulence.

OMEPRAZOLE

KG60484QX9

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Status:

US Approved Rx (2016)

First approved in 1989

Class (Stereo):

CHEMICAL (RACEMIC)

Targets:

Potassium-transporting ATPase

Conditions:

Gastroesophageal reflux disease

Pathological hypersecretory conditions

Esomeprazole strontium is a proton pump inhibitor. It suppresses gastric acid secretion by specific inhibition H+/K+ ATPase in the gastric parietal cell. The S- and R-isomers of omeprazole are protonated and converted in the acidic compartment of the...

parietal cell forming the active inhibitor, the achiral sulphenamide. By acting specifically on the proton pump, esomeprazole blocks the final step in acid production, thus reducing gastric acidity. The drug is indicated for the treatment of gastroesophageal reflux disease, reduction the risk of NSAID-associated gastric ulcer, eradication of H.pylori, and pathological hypersecretory conditions.

HHS VULNERABILITY DISCLOSURE

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