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US Approved OTC

9

US Previously Marketed

6

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Primary Target

Bacterial 70S ribosome

15

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Highest Phase

Approved

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Approval Year

1953

9

1971

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Condition

Bacterial infections

9

Acute gonorrheal urethritis

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Treatment Modality

Curative

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CNS Activity

CNS Penetrant

9

CNS Non-penetrant

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Originator

Pfizer|Lederle

9

Sokolski, W.T.|Chidester, C.G.|Schadewald, L.K.

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Chemical

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CAS

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FDA UNII

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PUBCHEM

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SMS_ID

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NCI_THESAURUS

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ATC Level 1

ANTIINFECTIVES FOR SYSTEMIC USE

2

ALIMENTARY TRACT AND METABOLISM

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DERMATOLOGICALS

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SENSORY ORGANS

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ATC Level 2

ANTIBACTERIALS FOR SYSTEMIC USE

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ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE

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DRUGS FOR ACID RELATED DISORDERS

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OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS

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OPHTHALMOLOGICALS

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ATC Level 3

ANTIBIOTICS FOR TOPICAL USE

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ANTIINFECTIVES

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COMBINATIONS OF ANTIBACTERIALS

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DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)

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OTHER ANTIBACTERIALS

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ATC Level 4

Antibiotics

1

Antiinfectives

1

Antiinfectives and antiseptics for local oral treatment

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Combinations for eradication of Helicobacter pylori

1

Combinations of antibacterials

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Substance Form

Salts, Hydrates, Esters, etc.

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TETRACYCLINE PHOSPHATE COMPLEX

6B7BK5H33B

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Status:

US Approved OTC

First approved in 1953

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Bacterial 70S ribosome

Conditions:

Bacterial infections

Discovered as natural products from actinomycetes soil bacteria, the tetracyclines were first reported in the scientific literature in 1948. They were noted for their broad spectrum antibacterial activity and were commercialized with clinical success...

beginning in the late 1940s to the early 1950s. By catalytic hydrogenation of Aureomycin, using palladium metal and hydrogen, the C7 deschloro derivative was synthesized, producing a compound of higher potency, a better solubility profile, and favorable pharmacological activity; it was subsequently named tetracycline. Tetracyclines are primarily bacteriostatic and exert their antimicrobial effect by the inhibition of protein synthesis by binding to the 30S ribosomal subunit. Tetracycline is active against a broad range of gram-negative and gram-positive organisms. Tetracycline is indicated in the treatment of infections caused by susceptible strains. To reduce the development of drug-resistant bacteria and maintain the effectiveness of tetracycline hydrochloride and other antibacterial drugs, tetracycline hydrochloride should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.

SPECTINOMYCIN

93AKI1U6QF

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Status:

US Previously Marketed

First approved in 1971

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Bacterial 70S ribosome

Conditions:

Acute gonorrheal urethritis

Acute gonorrheal urethritis

Acute gonorrheal urethritis

Spectinomycin is an antibiotic produced by Streptomyces spectabilis. It is active against gram-negative bacteria and used for the treatment of acute gonorrheal urethritis and proctitis in the male and acute gonorrheal cervicitis and proctitis in the ...

female when due to susceptible strains of Neisseria gonorrhoeae. In vitro studies have shown spectinomycin to be active against most strains of Neisseria gonorrhoeae (minimum inhibitory concentration <7.5 to 20 mcg/mL). Footprint studies indicate that spectinomycin exerts regional effects on ribosomal structure. Spectinomycin hydrochloride is an inhibitor of protein synthesis in the bacterial cell; the site of action is the 30S ribosomal subunit. The antibiotic is not significantly bound to plasma protein. Spectinomycin was discovered 1961. It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system. This antibiotic is no longer available in the United States. Pfizer has discontinued distribution of spectinomycin (Trobicin) in the U.S. The drug continues to be distributed outside the U.S.

DITETRACYCLINE TETRASODIUM EDETATE

WX0A0IT7K5

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Status:

US Approved OTC

First approved in 1953

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Bacterial 70S ribosome

Conditions:

Bacterial infections

Discovered as natural products from actinomycetes soil bacteria, the tetracyclines were first reported in the scientific literature in 1948. They were noted for their broad spectrum antibacterial activity and were commercialized with clinical success...

beginning in the late 1940s to the early 1950s. By catalytic hydrogenation of Aureomycin, using palladium metal and hydrogen, the C7 deschloro derivative was synthesized, producing a compound of higher potency, a better solubility profile, and favorable pharmacological activity; it was subsequently named tetracycline. Tetracyclines are primarily bacteriostatic and exert their antimicrobial effect by the inhibition of protein synthesis by binding to the 30S ribosomal subunit. Tetracycline is active against a broad range of gram-negative and gram-positive organisms. Tetracycline is indicated in the treatment of infections caused by susceptible strains. To reduce the development of drug-resistant bacteria and maintain the effectiveness of tetracycline hydrochloride and other antibacterial drugs, tetracycline hydrochloride should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.

TETRACYCLINE TRIHYDRATE

93V6NC52SB

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Status:

US Approved OTC

First approved in 1953

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Bacterial 70S ribosome

Conditions:

Bacterial infections

Discovered as natural products from actinomycetes soil bacteria, the tetracyclines were first reported in the scientific literature in 1948. They were noted for their broad spectrum antibacterial activity and were commercialized with clinical success...

beginning in the late 1940s to the early 1950s. By catalytic hydrogenation of Aureomycin, using palladium metal and hydrogen, the C7 deschloro derivative was synthesized, producing a compound of higher potency, a better solubility profile, and favorable pharmacological activity; it was subsequently named tetracycline. Tetracyclines are primarily bacteriostatic and exert their antimicrobial effect by the inhibition of protein synthesis by binding to the 30S ribosomal subunit. Tetracycline is active against a broad range of gram-negative and gram-positive organisms. Tetracycline is indicated in the treatment of infections caused by susceptible strains. To reduce the development of drug-resistant bacteria and maintain the effectiveness of tetracycline hydrochloride and other antibacterial drugs, tetracycline hydrochloride should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.

TETRACYCLINE PHOSPHATE

NZ662XY5PP

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Status:

US Approved OTC

First approved in 1953

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Bacterial 70S ribosome

Conditions:

Bacterial infections

Discovered as natural products from actinomycetes soil bacteria, the tetracyclines were first reported in the scientific literature in 1948. They were noted for their broad spectrum antibacterial activity and were commercialized with clinical success...

beginning in the late 1940s to the early 1950s. By catalytic hydrogenation of Aureomycin, using palladium metal and hydrogen, the C7 deschloro derivative was synthesized, producing a compound of higher potency, a better solubility profile, and favorable pharmacological activity; it was subsequently named tetracycline. Tetracyclines are primarily bacteriostatic and exert their antimicrobial effect by the inhibition of protein synthesis by binding to the 30S ribosomal subunit. Tetracycline is active against a broad range of gram-negative and gram-positive organisms. Tetracycline is indicated in the treatment of infections caused by susceptible strains. To reduce the development of drug-resistant bacteria and maintain the effectiveness of tetracycline hydrochloride and other antibacterial drugs, tetracycline hydrochloride should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.

TETRACYCLINE CALCIUM

9ON2SH59JS

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Status:

US Approved OTC

First approved in 1953

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Bacterial 70S ribosome

Conditions:

Bacterial infections

Discovered as natural products from actinomycetes soil bacteria, the tetracyclines were first reported in the scientific literature in 1948. They were noted for their broad spectrum antibacterial activity and were commercialized with clinical success...

beginning in the late 1940s to the early 1950s. By catalytic hydrogenation of Aureomycin, using palladium metal and hydrogen, the C7 deschloro derivative was synthesized, producing a compound of higher potency, a better solubility profile, and favorable pharmacological activity; it was subsequently named tetracycline. Tetracyclines are primarily bacteriostatic and exert their antimicrobial effect by the inhibition of protein synthesis by binding to the 30S ribosomal subunit. Tetracycline is active against a broad range of gram-negative and gram-positive organisms. Tetracycline is indicated in the treatment of infections caused by susceptible strains. To reduce the development of drug-resistant bacteria and maintain the effectiveness of tetracycline hydrochloride and other antibacterial drugs, tetracycline hydrochloride should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.

TETRACYCLINE 4-GUAIACOLSULFONATE

05T77P89WE

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Status:

US Approved OTC

First approved in 1953

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Bacterial 70S ribosome

Conditions:

Bacterial infections

Discovered as natural products from actinomycetes soil bacteria, the tetracyclines were first reported in the scientific literature in 1948. They were noted for their broad spectrum antibacterial activity and were commercialized with clinical success...

beginning in the late 1940s to the early 1950s. By catalytic hydrogenation of Aureomycin, using palladium metal and hydrogen, the C7 deschloro derivative was synthesized, producing a compound of higher potency, a better solubility profile, and favorable pharmacological activity; it was subsequently named tetracycline. Tetracyclines are primarily bacteriostatic and exert their antimicrobial effect by the inhibition of protein synthesis by binding to the 30S ribosomal subunit. Tetracycline is active against a broad range of gram-negative and gram-positive organisms. Tetracycline is indicated in the treatment of infections caused by susceptible strains. To reduce the development of drug-resistant bacteria and maintain the effectiveness of tetracycline hydrochloride and other antibacterial drugs, tetracycline hydrochloride should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.

TETRACYCLINE HYDROCHLORIDE

P6R62377KV

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Status:

US Approved OTC

First approved in 1953

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Bacterial 70S ribosome

Conditions:

Bacterial infections

Discovered as natural products from actinomycetes soil bacteria, the tetracyclines were first reported in the scientific literature in 1948. They were noted for their broad spectrum antibacterial activity and were commercialized with clinical success...

beginning in the late 1940s to the early 1950s. By catalytic hydrogenation of Aureomycin, using palladium metal and hydrogen, the C7 deschloro derivative was synthesized, producing a compound of higher potency, a better solubility profile, and favorable pharmacological activity; it was subsequently named tetracycline. Tetracyclines are primarily bacteriostatic and exert their antimicrobial effect by the inhibition of protein synthesis by binding to the 30S ribosomal subunit. Tetracycline is active against a broad range of gram-negative and gram-positive organisms. Tetracycline is indicated in the treatment of infections caused by susceptible strains. To reduce the development of drug-resistant bacteria and maintain the effectiveness of tetracycline hydrochloride and other antibacterial drugs, tetracycline hydrochloride should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.

TETRACYCLINE HEXAHYDRATE

7D3LAT01HT

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Status:

US Approved OTC

First approved in 1953

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Bacterial 70S ribosome

Conditions:

Bacterial infections

Discovered as natural products from actinomycetes soil bacteria, the tetracyclines were first reported in the scientific literature in 1948. They were noted for their broad spectrum antibacterial activity and were commercialized with clinical success...

beginning in the late 1940s to the early 1950s. By catalytic hydrogenation of Aureomycin, using palladium metal and hydrogen, the C7 deschloro derivative was synthesized, producing a compound of higher potency, a better solubility profile, and favorable pharmacological activity; it was subsequently named tetracycline. Tetracyclines are primarily bacteriostatic and exert their antimicrobial effect by the inhibition of protein synthesis by binding to the 30S ribosomal subunit. Tetracycline is active against a broad range of gram-negative and gram-positive organisms. Tetracycline is indicated in the treatment of infections caused by susceptible strains. To reduce the development of drug-resistant bacteria and maintain the effectiveness of tetracycline hydrochloride and other antibacterial drugs, tetracycline hydrochloride should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.

TETRACYCLINE

F8VB5M810T

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Search for Structure

Status:

US Approved OTC

First approved in 1953

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Bacterial 70S ribosome

Conditions:

Bacterial infections

Discovered as natural products from actinomycetes soil bacteria, the tetracyclines were first reported in the scientific literature in 1948. They were noted for their broad spectrum antibacterial activity and were commercialized with clinical success...

beginning in the late 1940s to the early 1950s. By catalytic hydrogenation of Aureomycin, using palladium metal and hydrogen, the C7 deschloro derivative was synthesized, producing a compound of higher potency, a better solubility profile, and favorable pharmacological activity; it was subsequently named tetracycline. Tetracyclines are primarily bacteriostatic and exert their antimicrobial effect by the inhibition of protein synthesis by binding to the 30S ribosomal subunit. Tetracycline is active against a broad range of gram-negative and gram-positive organisms. Tetracycline is indicated in the treatment of infections caused by susceptible strains. To reduce the development of drug-resistant bacteria and maintain the effectiveness of tetracycline hydrochloride and other antibacterial drugs, tetracycline hydrochloride should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.

Showing 1 - 10 of 15 results

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