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Status:
Possibly Marketed Outside US
Source:
NCT00483795: Phase 4 Interventional Completed Corneal Staining
Source URL:
First approved in 1992
Source:
21 CFR 358A
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Aminomethylpropanol is a synthetic ingredient that functions as a buffer to adjust the pH of cosmetics and personal care products. In cosmetics and personal care products, aminomethylpropanol is used in the formulation of creams and lotions, hair sprays, wave sets, hair dyes and colors, eye and facial products, and other hair and skin care products. The main function of aminomethylpropanol in these products is to establish and hold the pH. The Food and Drug Administration (FDA) includes aminomethylpropanol on its list of indirect food additives as a component of adhesives that are in contact with food. The European Chemicals Agency (ECHA) identifies that “substance causes serious eye irritation, is harmful to aquatic life with long lasting effects and causes skin irritation, causes serious eye damage.” Toxicologically significant concentrations of AMP are unlikely to be achieved in the systemic circulation and/or target tissues in humans as a result of dermal application of products containing aminomethylpropanol. Systemically absorbed dose will be rapidly eliminated from the body with little remaining at the application site.
Status:
Possibly Marketed Outside US
Source:
HERBALIFE SKIN 7 DAY RESULTS KIT
Source URL:
First approved in 1992
Source:
21 CFR 358H
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Glycol distereate is the diester of stearic acid and ethylene glycol. It is used in cosmetic products (creams, shampoos, moisturizers, soaps) because of its pearlescent, opacity and moisturizing effects as well as its high foaming capacity. It is also used as a food additive. There are no known safety concerns.
Status:
Possibly Marketed Outside US
Source:
ERGOLOID MESYLATES
Source URL:
First approved in 1991
Source:
ANDA081113
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Epicriptine or beta-dihydroergocryptine is a dopamine agonist of the ergoline class. It constitutes one third of the mixture known as dihydroergocryptine, the other two thirds consisting of alpha-dihydroergocryptine. The alpha differs from the beta form only in the position of a single methyl group, which is a consequence of the biosynthesis in which the proteinogenic amino acid isoleucine is replaced by leucine. Mesylate salt of dihydro-β-ergocryptine is an active part of the drug: Ergoloid Mesylate, which is used for treatment of symptoms of an idiopathic decline in mental capacity (i.e., cognitive and interpersonal skills, mood, self-care, apparent motivation) can experience some symptomatic relief upon treatment with ergoloid mesylates preparations.
Status:
Possibly Marketed Outside US
Source:
SURFAXIN by Chevreul, M.E.
Source URL:
First approved in 1990
Source:
21 CFR 358A
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Palmitic acid is a saturated fatty acid, the principal constituent of refined palm oil, present in the diet and synthesized endogenously. Palmitic acid is able to activate the orphan G protein-coupled receptor GPR40. Palmitic acid was also a weak ligand of peroxisome proliferator-activated receptor gamma. Palmitic acid is a ligand of lipid chaperones - the fatty acid-binding proteins (FABPs). Dietary palm oil and palmitic acid may play a role in the development of obesity, type 2 diabetes mellitus, cardiovascular diseases and cancer.
Status:
Possibly Marketed Outside US
Source:
CORID
Source URL:
First approved in 1990
Source:
AMPROLIUM by Phibro Animal Health Ltd.
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Amprolium Hydrochloride is a broad spectrum, potent coccidiostat (anti-protozoal) used for the treatment and prevention of Coccidiosis in cattle, goats, sheep, and poultry (chicken and turkey) in veterinary. Amprolium probably acts by inhibiting thiamine uptake by parasites and thus creates disorders in the metabolism of parasites.
Status:
Possibly Marketed Outside US
Source:
SYNALAR TS
Source URL:
First approved in 1990
Source:
21 CFR 358A
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Status:
Possibly Marketed Outside US
First approved in 1990
Source:
NDA019882
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Betiatide (CAS 103725-47-9; aka S-benzoylmercapto¬acetyltriglycine or 2-[[2-[[2-[(2-benzoylsulfanylacetyl)¬amino]¬acetyl]¬amino]¬acetyl]¬amino] acetic acid) is the API in TechneScan MAG3™; a kit for the preparation of technetium Tc 99m mertiatide. It is used in the diagnosis of congenital and acquired abnormalities, renal failure, urinary tract obstruction and calculi. Furthermore it is used in providing renal function, split function, renal angiograms and renogram curves for whole kidney and renal cortex. Betiatide is light sensitive and must be protected as such.
Status:
Possibly Marketed Outside US
Source:
NCT04677712: Phase 4 Interventional Completed Edematous Fibrosclerotic Panniculopathy (EFP)
(2020)
Source URL:
First approved in 1990
Source:
M017
Source URL:
Class (Stereo):
CHEMICAL (MIXED)
Conditions:
Squalane is an emollient used as cosmetic ingredient. It naturally occurs in small amounts in the lipid layers of skin, and along with its precursor squalene, prevents moisture loss while restoring skin’s suppleness and flexibility. It is soluble in all common cosmetic media, and can be used without limits in all types of formulations being non-toxic and a non-irritant. It is used in skin care products as an active or inactive ingredient and can be used in emulsion composition in vaccines and some drug compositions. Squalane is a hydrogenated squalene - a natural product first extracted from shark liver oil, and later isolated from olive and palm oils. In a pure state, it is a mobile, colorless, odorless and tasteless hydrocarbon oil with good physical and chemical stability. Up to date, anticancer, antioxidant, drug carrier, detoxifier, skin hydrating, and emollient activities of squalane have been reported both in animal models and in vitro environments.
Status:
Possibly Marketed Outside US
First approved in 1990
Source:
NADA140833
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Clorsulon is a compound belonging to the benzenesulphonamide family. It is used in veterinary medicine for the treatment of liver fluke (monotherapy), gasrtointestinal and lung worms, lice, grubs and mites (in combination with ivermectin) in cattles. Clorsulon inhibits the enzymes involved in the glycolytic pathways of the common liver fluke (Fasciola hepatica or Fasciola gigantica), namely phosphoglycerate kinase and phosphoglyceromutase.
Status:
Possibly Marketed Outside US
Source:
TECHNETIUM TC 99M SESTAMIBI
Source URL:
First approved in 1990
Source:
NDA019785
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions: