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Details

Stereochemistry ACHIRAL
Molecular Formula C4H11NO
Molecular Weight 89.1362
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of AMINOMETHYLPROPANOL

SMILES

CC(C)(N)CO

InChI

InChIKey=CBTVGIZVANVGBH-UHFFFAOYSA-N
InChI=1S/C4H11NO/c1-4(2,5)3-6/h6H,3,5H2,1-2H3

HIDE SMILES / InChI

Molecular Formula C4H11NO
Molecular Weight 89.1362
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Aminomethylpropanol is a synthetic ingredient that functions as a buffer to adjust the pH of cosmetics and personal care products. In cosmetics and personal care products, aminomethylpropanol is used in the formulation of creams and lotions, hair sprays, wave sets, hair dyes and colors, eye and facial products, and other hair and skin care products. The main function of aminomethylpropanol in these products is to establish and hold the pH. The Food and Drug Administration (FDA) includes aminomethylpropanol on its list of indirect food additives as a component of adhesives that are in contact with food. The European Chemicals Agency (ECHA) identifies that “substance causes serious eye irritation, is harmful to aquatic life with long lasting effects and causes skin irritation, causes serious eye damage.” Toxicologically significant concentrations of AMP are unlikely to be achieved in the systemic circulation and/or target tissues in humans as a result of dermal application of products containing aminomethylpropanol. Systemically absorbed dose will be rapidly eliminated from the body with little remaining at the application site.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Inactive ingredient
24 HOUR PIMPLE PUNISHER
PubMed

PubMed

TitleDatePubMed
[Influences of uncommon isoenzymes on determination of alkaline phosphatase activity by dry-chemistry analyzers].
2001 Apr
Modifying hepatic phospholipid synthesis associates with biliary phospholipid secretion rate in a transporter-independent manner in rats: relation to canalicular membrane fluidity.
2001 Jun
Preparation and characterisation of a range of diclofenac salts.
2001 Sep 11
Poly(amide ester)s from 2,6-pyridinedicarboxylic acid and ethanolamine derivatives: identification of macrocycles by matrix-assisted laser desorption/ionization mass spectrometry.
2002
Fluorimetric determination of alkaline phosphatase in solid and fluid dairy products.
2002 Apr 8
The effect of different buffers and amounts of intestinal alkaline phosphatase isoforms on total alkaline phosphatase activity.
2002 May 7
Vascular responsiveness to dimethylaminoethyl methacrylate and its degradation products.
2003 Jul 1
Facile syntheses of oxazolines and thiazolines with N-acylbenzotriazoles under microwave irradiation.
2004 Feb 6
Determination of carbon dioxide and acid components in exhaust gas by suppressed ion chromatography.
2004 Jan
Dimethylethanolamine does not prevent liver failure in phosphatidylethanolamine N-methyltransferase-deficient mice fed a choline-deficient diet.
2004 Mar 22
Rhodovarius lipocyclicus gen. nov. sp. nov., a new genus of the alpha-1 subclass of the Proteobacteria.
2004 Sep
Comparative analysis of mouse skeletal muscle fibre type composition and contractile responses to calcium channel blocker.
2005 Feb 14
Ion exchange preconcentration and separation of mercury species by CE with indirect contactless conductometric detection.
2006 Nov
Proteomic analysis of plasma membrane and secretory vesicles from human neutrophils.
2007 Aug 10
2-(2-Methoxy-phen-yl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole.
2007 Dec 6
Synthesis and characterization of a new layered fluoroaluminophosphate (C4H11NOH)3.5[Al4(PO4)5F] x 0.5H3O with extra-large 16-rings.
2007 Jan 8
Ethanolamine and related amino alcohols increase basal and evoked release of [3H]-D-aspartic acid from synaptosomes by enhancing the filling of synaptic vesicles.
2007 Jul 2
Oxidation of N-nitrosodimethylamine (NDMA) precursors with ozone and chlorine dioxide: kinetics and effect on NDMA formation potential.
2007 Mar 15
[Study of new blended chemical absorbents to absorb CO2].
2007 Nov
Evaluation of a method for measuring tissue non-specific alkaline phosphatase activity in healthy subjects.
2007 Nov
Adiponectin and AMP kinase activator stimulate proliferation, differentiation, and mineralization of osteoblastic MC3T3-E1 cells.
2007 Nov 29
Gene profile analysis of osteoblast genes differentially regulated by histone deacetylase inhibitors.
2007 Oct 9
Membrane potential controls adipogenic and osteogenic differentiation of mesenchymal stem cells.
2008
Regeneration of 2-amino-2-methyl-1-propanol used for carbon dioxide absorption.
2008
Influence of additives including amine and hydroxyl groups on aqueous ammonia absorbent for CO2 capture.
2008 Apr 10
Pharmacokinetics of aminomethylpropanol in rats following oral and a novel dermal study design.
2008 Feb
1-Hydroxymethyl-1-methylethan-aminium chloride.
2008 May 24
Biochemical characterization of the initial steps of the Kennedy pathway in Trypanosoma brucei: the ethanolamine and choline kinases.
2008 Oct 1
Removal characteristics of CO2 using aqueous MEA/AMP solutions in the absorption and regeneration process.
2009
Serotonin increases cilia-driven particle transport via an acetylcholine-independent pathway in the mouse trachea.
2009
Epidemiology and genetic epidemiology of the liver function test proteins.
2009
Optimization of automated large-scale production of [(18)F]fluoroethylcholine for PET prostate cancer imaging.
2009 Jul
Influence of fluorocarbon flat-membrane hydrophobicity on carbon dioxide recovery.
2009 Jun
Isolation, identification and expression analysis of salt-induced genes in Suaeda maritima, a natural halophyte, using PCR-based suppression subtractive hybridization.
2009 Jun 5
Cell response to a newly developed Ti-10Ta-10Nb alloy and its sputtered nanoscale coating.
2009 Mar
Advanced oxidation and reduction process chemistry of methyl tert-butyl ether (MTBE) reaction intermediates in aqueous solution: 2-methoxy-2-methyl-propanal, 2-methoxy-2-methyl-propanol, and 2-methoxy-2-methyl-propanoic acid.
2009 Nov
Effect of short-time povidone-iodine application on osteoblast proliferation and differentiation.
2009 Oct 16
Helminth immunoregulation: the role of parasite secreted proteins in modulating host immunity.
2009 Sep
Developmental and molecular physiological evidence for the role of phosphoenolpyruvate carboxylase in rapid cotton fibre elongation.
2010
Estrogens attenuate oxidative stress and the differentiation and apoptosis of osteoblasts by DNA-binding-independent actions of the ERalpha.
2010 Apr
Nucleophilicity and accessibility calculations of alkanolamines: applications to carbon dioxide absorption reactions.
2010 Dec 16
Crystal structure and electronic properties of 2-amino-2-methyl-1-propanol (AMP) carbamate.
2010 Dec 28
Determination of calcium in synovial fluid samples as an aid to diagnosing osteoarthritis.
2010 Feb
Association of urinary bisphenol a concentration with heart disease: evidence from NHANES 2003/06.
2010 Jan 13
Effects of shape, porosity, and operating parameters on carbon dioxide recovery in polytetrafluoroethylene membranes.
2010 Jul 15
Intranasal delivery of influenza subunit vaccine formulated with GEM particles as an adjuvant.
2010 Jun
Harmonization of values for serum alkaline phosphatase catalytic activity concentration employing commutable calibration materials.
2010 Jun 3
Evaluation of alkanolamine solutions for carbon dioxide removal in cross-flow rotating packed beds.
2010 Mar 15
N-(2-Hy-droxy-1,1-dimethyl-eth-yl)-benzene-sulfonamide.
2010 Oct 31
Distinguishing between maternally-mediated and directly embryotoxic modes-of-action for postimplantation loss induced in rats by 2-amino-2-methylpropanol.
2014 Nov
Patents

Sample Use Guides

In Vivo Use Guide
18 mg/kg in water
Route of Administration: Oral; Topical
Substance Class Chemical
Created
by admin
on Tue Oct 22 05:28:36 UTC 2019
Edited
by admin
on Tue Oct 22 05:28:36 UTC 2019
Record UNII
LU49E6626Q
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
AMINOMETHYLPROPANOL
II  
Systematic Name English
2-AMINO-2-METHYL-1-PROPANOL [MI]
Common Name English
2-AMINO-2-METHYL-1-PROPANOL [VANDF]
Common Name English
2-AMINO-2-METHYL-1-PROPANOL
MI   VANDF   WHO-DD  
Systematic Name English
2-AMINOISOBUTANOL
Common Name English
NSC-441
Code English
AMINOMETHYL PROPANOL [INCI]
Common Name English
2-AMINO-2-METHYLPROPAN-1-OL
Systematic Name English
2-AMINO-2-METHYL-1-PROPANOL [WHO-DD]
Common Name English
2-AMINO-2-METHYLPROPANOL [HSDB]
Common Name English
1-PROPANOL, 2-AMINO-2-METHYL-
Systematic Name English
ISOBUTANOLAMINE
Common Name English
AMINOMETHYL PROPANOL
INCI  
INCI  
Official Name English
AMP-95
Brand Name English
AMINOMETHYLPROPANOL [II]
Common Name English
Classification Tree Code System Code
CFR 21 CFR 176.170
Created by admin on Tue Oct 22 05:28:36 UTC 2019 , Edited by admin on Tue Oct 22 05:28:36 UTC 2019
EPA PESTICIDE CODE 5801
Created by admin on Tue Oct 22 05:28:36 UTC 2019 , Edited by admin on Tue Oct 22 05:28:36 UTC 2019
Code System Code Type Description
MERCK INDEX
M1716
Created by admin on Tue Oct 22 05:28:36 UTC 2019 , Edited by admin on Tue Oct 22 05:28:36 UTC 2019
PRIMARY Merck Index
PUBCHEM
11807
Created by admin on Tue Oct 22 05:28:36 UTC 2019 , Edited by admin on Tue Oct 22 05:28:36 UTC 2019
PRIMARY
MESH
C006551
Created by admin on Tue Oct 22 05:28:36 UTC 2019 , Edited by admin on Tue Oct 22 05:28:36 UTC 2019
PRIMARY
CAS
124-68-5
Created by admin on Tue Oct 22 05:28:36 UTC 2019 , Edited by admin on Tue Oct 22 05:28:36 UTC 2019
PRIMARY
ECHA (EC/EINECS)
204-709-8
Created by admin on Tue Oct 22 05:28:36 UTC 2019 , Edited by admin on Tue Oct 22 05:28:36 UTC 2019
PRIMARY
NCI_THESAURUS
C77445
Created by admin on Tue Oct 22 05:28:36 UTC 2019 , Edited by admin on Tue Oct 22 05:28:36 UTC 2019
PRIMARY
HSDB
124-68-5
Created by admin on Tue Oct 22 05:28:36 UTC 2019 , Edited by admin on Tue Oct 22 05:28:36 UTC 2019
PRIMARY
EVMPD
SUB128087
Created by admin on Tue Oct 22 05:28:36 UTC 2019 , Edited by admin on Tue Oct 22 05:28:36 UTC 2019
PRIMARY
NCI_THESAURUS
C45678
Created by admin on Tue Oct 22 05:28:36 UTC 2019 , Edited by admin on Tue Oct 22 05:28:36 UTC 2019
CONCEPT Industrial Aid
RXCUI
1310544
Created by admin on Tue Oct 22 05:28:36 UTC 2019 , Edited by admin on Tue Oct 22 05:28:36 UTC 2019
PRIMARY RxNorm
EPA CompTox
124-68-5
Created by admin on Tue Oct 22 05:28:36 UTC 2019 , Edited by admin on Tue Oct 22 05:28:36 UTC 2019
PRIMARY
Related Record Type Details
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT