Details
Stereochemistry | ACHIRAL |
Molecular Formula | C4H11NO |
Molecular Weight | 89.1362 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)(N)CO
InChI
InChIKey=CBTVGIZVANVGBH-UHFFFAOYSA-N
InChI=1S/C4H11NO/c1-4(2,5)3-6/h6H,3,5H2,1-2H3
Molecular Formula | C4H11NO |
Molecular Weight | 89.1362 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Aminomethylpropanol is a synthetic ingredient that functions as a buffer to adjust the pH of cosmetics and personal care products. In cosmetics and personal care products, aminomethylpropanol is used in the formulation of creams and lotions, hair sprays, wave sets, hair dyes and colors, eye and facial products, and other hair and skin care products. The main function of aminomethylpropanol in these products is to establish and hold the pH. The Food and Drug Administration (FDA) includes aminomethylpropanol on its list of indirect food additives as a component of adhesives that are in contact with food. The European Chemicals Agency (ECHA) identifies that “substance causes serious eye irritation, is harmful to aquatic life with long lasting effects and causes skin irritation, causes serious eye damage.” Toxicologically significant concentrations of AMP are unlikely to be achieved in the systemic circulation and/or target tissues in humans as a result of dermal application of products containing aminomethylpropanol. Systemically absorbed dose will be rapidly eliminated from the body with little remaining at the application site.
Approval Year
PubMed
Title | Date | PubMed |
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[Influences of uncommon isoenzymes on determination of alkaline phosphatase activity by dry-chemistry analyzers]. | 2001 Apr |
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Alkaline phosphatase activity: new assay for the Reflotron system. Results of the evaluation in eight clinical laboratories. | 2001 Jan |
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Modifying hepatic phospholipid synthesis associates with biliary phospholipid secretion rate in a transporter-independent manner in rats: relation to canalicular membrane fluidity. | 2001 Jun |
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Preparation and characterisation of a range of diclofenac salts. | 2001 Sep 11 |
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Fluorimetric determination of alkaline phosphatase in solid and fluid dairy products. | 2002 Apr 8 |
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Dimethylethanolamine does not prevent liver failure in phosphatidylethanolamine N-methyltransferase-deficient mice fed a choline-deficient diet. | 2004 Mar 22 |
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Synthesis of levan in water-miscible organic solvents. | 2004 Oct 19 |
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ATR-FTIR characterization of transport properties of benzoic acid ion-pairs in silicone membranes. | 2004 Sep 28 |
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Comparative analysis of mouse skeletal muscle fibre type composition and contractile responses to calcium channel blocker. | 2005 Feb 14 |
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Ion chromatographic analysis of amines, alkanolamines, and associated anions in concrete. | 2005 Mar |
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Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells. | 2005 Nov 11 |
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Ion exchange preconcentration and separation of mercury species by CE with indirect contactless conductometric detection. | 2006 Nov |
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Proteomic analysis of plasma membrane and secretory vesicles from human neutrophils. | 2007 Aug 10 |
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2-(2-Methoxy-phen-yl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole. | 2007 Dec 6 |
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Micro-morphologic changes around biophysically-stimulated titanium implants in ovariectomized rats. | 2007 Jul 16 |
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Enhanced enteric properties and stability of shellac films through composite salts formation. | 2007 Nov |
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Gene profile analysis of osteoblast genes differentially regulated by histone deacetylase inhibitors. | 2007 Oct 9 |
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Membrane potential controls adipogenic and osteogenic differentiation of mesenchymal stem cells. | 2008 |
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Regeneration of 2-amino-2-methyl-1-propanol used for carbon dioxide absorption. | 2008 |
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Pharmacokinetics of aminomethylpropanol in rats following oral and a novel dermal study design. | 2008 Feb |
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Oxidation of suspected N-nitrosodimethylamine (NDMA) precursors by ferrate (VI): kinetics and effect on the NDMA formation potential of natural waters. | 2008 Jan |
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1-Hydroxymethyl-1-methylethan-aminium chloride. | 2008 May 24 |
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Bis[N-(2-hydroxy-ethyl)-N-methyl-glycinato]copper(II). | 2008 Nov 22 |
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Serotonin increases cilia-driven particle transport via an acetylcholine-independent pathway in the mouse trachea. | 2009 |
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Epidemiology and genetic epidemiology of the liver function test proteins. | 2009 |
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Optimization of automated large-scale production of [(18)F]fluoroethylcholine for PET prostate cancer imaging. | 2009 Jul |
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Influence of fluorocarbon flat-membrane hydrophobicity on carbon dioxide recovery. | 2009 Jun |
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Isolation, identification and expression analysis of salt-induced genes in Suaeda maritima, a natural halophyte, using PCR-based suppression subtractive hybridization. | 2009 Jun 5 |
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Cell response to a newly developed Ti-10Ta-10Nb alloy and its sputtered nanoscale coating. | 2009 Mar |
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1,4a,7-Trimethyl-7-vinyl-1,2,3,4,4a,4b,5,6,7,8,10,10a-dodeca-hydro-phenanthrene-1-carboxylic acid. | 2009 May 29 |
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Advanced oxidation and reduction process chemistry of methyl tert-butyl ether (MTBE) reaction intermediates in aqueous solution: 2-methoxy-2-methyl-propanal, 2-methoxy-2-methyl-propanol, and 2-methoxy-2-methyl-propanoic acid. | 2009 Nov |
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Helminth immunoregulation: the role of parasite secreted proteins in modulating host immunity. | 2009 Sep |
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Capture of carbon dioxide by amine-impregnated as-synthesized MCM-41. | 2010 |
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Developmental and molecular physiological evidence for the role of phosphoenolpyruvate carboxylase in rapid cotton fibre elongation. | 2010 |
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Nucleophilicity and accessibility calculations of alkanolamines: applications to carbon dioxide absorption reactions. | 2010 Dec 16 |
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Crystal structure and electronic properties of 2-amino-2-methyl-1-propanol (AMP) carbamate. | 2010 Dec 28 |
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Determination of calcium in synovial fluid samples as an aid to diagnosing osteoarthritis. | 2010 Feb |
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Association of urinary bisphenol a concentration with heart disease: evidence from NHANES 2003/06. | 2010 Jan 13 |
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Effects of shape, porosity, and operating parameters on carbon dioxide recovery in polytetrafluoroethylene membranes. | 2010 Jul 15 |
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Harmonization of values for serum alkaline phosphatase catalytic activity concentration employing commutable calibration materials. | 2010 Jun 3 |
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Evaluation of alkanolamine solutions for carbon dioxide removal in cross-flow rotating packed beds. | 2010 Mar 15 |
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N-(2-Hy-droxy-1,1-dimethyl-eth-yl)-benzene-sulfonamide. | 2010 Oct 31 |
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Distinguishing between maternally-mediated and directly embryotoxic modes-of-action for postimplantation loss induced in rats by 2-amino-2-methylpropanol. | 2014 Nov |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/17961896
Curator's Comment: rat data
18 mg/kg in water
Route of Administration:
Other
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:04:53 UTC 2023
by
admin
on
Fri Dec 15 15:04:53 UTC 2023
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Record UNII |
LU49E6626Q
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Record Status |
Validated (UNII)
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CFR |
21 CFR 176.170
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EPA PESTICIDE CODE |
5801
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11807
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C006551
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C45678
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CONCEPT | Industrial Aid | ||
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Aminomethyl propanol
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DTXSID8027032
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Related Record | Type | Details | ||
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SALT/SOLVATE -> PARENT | |||
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SALT/SOLVATE -> PARENT | |||
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SALT/SOLVATE -> PARENT |