U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C7H7BrN4O2.C4H11NO
Molecular Weight 348.196
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PAMABROM

SMILES

CC(C)(N)CO.CN1C2=C(N=C(Br)N2)C(=O)N(C)C1=O

InChI

InChIKey=ATOTUUBRFJHZQG-UHFFFAOYSA-N
InChI=1S/C7H7BrN4O2.C4H11NO/c1-11-4-3(9-6(8)10-4)5(13)12(2)7(11)14;1-4(2,5)3-6/h1-2H3,(H,9,10);6H,3,5H2,1-2H3

HIDE SMILES / InChI
Molecular Formula C4H11NO
Molecular Weight 89.1362
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C7H7BrN4O2
Molecular Weight 259.06
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Pamabrom is a diuretic drug, available in over-the-counter medications. The active diuretic ingredient in pamabrom is 8-bromotheophylline. It is used for the relief of temporary water weight gain; bloating; swelling; full feeling associated with the premenstrual and menstrual periods.

Approval Year

1952
114
Targets

Targets

Primary TargetPharmacologyConditionPotency
Antagonist
2849
 10.2 µM [Ki]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
Not Provided
511
DIUREX

Approved Use

Unknown
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
3685.6 ng/mL
EXPERIMENT
http://www.annexpublishers.co/full-text/JBS/3101/Bioanalytical-Method-for-Pamabrom-Determined-As-8-Bromotheophylline-and-its-Application-to-a-Pharmacokinetic-Study.php
25 mg single, oral
dose: 25 mg
route of administration: Oral
experiment type: SINGLE
co-administered: ACETAMINOPHEN
ACETAMINOPHEN
 BROMOTHEOPHYLLINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE
food status: FASTED
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
46210.49 ng × h/mL
EXPERIMENT
http://www.annexpublishers.co/full-text/JBS/3101/Bioanalytical-Method-for-Pamabrom-Determined-As-8-Bromotheophylline-and-its-Application-to-a-Pharmacokinetic-Study.php
25 mg single, oral
dose: 25 mg
route of administration: Oral
experiment type: SINGLE
co-administered: ACETAMINOPHEN
ACETAMINOPHEN
 BROMOTHEOPHYLLINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE
food status: FASTED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
21.35 h
EXPERIMENT
http://www.annexpublishers.co/full-text/JBS/3101/Bioanalytical-Method-for-Pamabrom-Determined-As-8-Bromotheophylline-and-its-Application-to-a-Pharmacokinetic-Study.php
25 mg single, oral
dose: 25 mg
route of administration: Oral
experiment type: SINGLE
co-administered: ACETAMINOPHEN
ACETAMINOPHEN
 BROMOTHEOPHYLLINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE
food status: FASTED
Doses

Doses

DosePopulationAdverse events​
25 mg 1 times / day multiple, oral
Dose: 25 mg, 1 times / day
Route: oral
Route: multiple
Dose: 25 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/19681920
unhealthy, 26 years
Health Status: unhealthy
Age Group: 26 years
Sex: F
Sources:
https://pubmed.ncbi.nlm.nih.gov/19681920
Disc. AE: Fixed drug eruption...
AEs leading to
discontinuation/dose reduction:
Fixed drug eruption
Sources:
https://pubmed.ncbi.nlm.nih.gov/19681920
900 mg 1 times / day multiple, oral
Highest studied dose
Dose: 900 mg, 1 times / day
Route: oral
Route: multiple
Dose: 900 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/13080166
unhealthy, 44-78 years
Health Status: unhealthy
Age Group: 44-78 years
Sex: M+F
Sources:
https://pubmed.ncbi.nlm.nih.gov/13080166
Disc. AE: Diarrhea...
AEs leading to
discontinuation/dose reduction:
Diarrhea (mild, 1 patient)
Sources:
https://pubmed.ncbi.nlm.nih.gov/13080166
600 mg 1 times / day multiple, oral
Dose: 600 mg, 1 times / day
Route: oral
Route: multiple
Dose: 600 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/13080166
unhealthy, 44-78 years
Health Status: unhealthy
Age Group: 44-78 years
Sex: M+F
Sources:
https://pubmed.ncbi.nlm.nih.gov/13080166
Disc. AE: Nausea, Vomiting...
AEs leading to
discontinuation/dose reduction:
Nausea (severe, 4 patients)
Vomiting (severe, 4 patients)
Skin rash (1 patient)
Sources:
https://pubmed.ncbi.nlm.nih.gov/13080166
AEs

AEs

AESignificanceDosePopulation
Fixed drug eruption Disc. AE
25 mg 1 times / day multiple, oral
Dose: 25 mg, 1 times / day
Route: oral
Route: multiple
Dose: 25 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/19681920
unhealthy, 26 years
Health Status: unhealthy
Age Group: 26 years
Sex: F
Sources:
https://pubmed.ncbi.nlm.nih.gov/19681920
Diarrhea mild, 1 patient
Disc. AE
900 mg 1 times / day multiple, oral
Highest studied dose
Dose: 900 mg, 1 times / day
Route: oral
Route: multiple
Dose: 900 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/13080166
unhealthy, 44-78 years
Health Status: unhealthy
Age Group: 44-78 years
Sex: M+F
Sources:
https://pubmed.ncbi.nlm.nih.gov/13080166
Skin rash 1 patient
Disc. AE
600 mg 1 times / day multiple, oral
Dose: 600 mg, 1 times / day
Route: oral
Route: multiple
Dose: 600 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/13080166
unhealthy, 44-78 years
Health Status: unhealthy
Age Group: 44-78 years
Sex: M+F
Sources:
https://pubmed.ncbi.nlm.nih.gov/13080166
Nausea severe, 4 patients
Disc. AE
600 mg 1 times / day multiple, oral
Dose: 600 mg, 1 times / day
Route: oral
Route: multiple
Dose: 600 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/13080166
unhealthy, 44-78 years
Health Status: unhealthy
Age Group: 44-78 years
Sex: M+F
Sources:
https://pubmed.ncbi.nlm.nih.gov/13080166
Vomiting severe, 4 patients
Disc. AE
600 mg 1 times / day multiple, oral
Dose: 600 mg, 1 times / day
Route: oral
Route: multiple
Dose: 600 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/13080166
unhealthy, 44-78 years
Health Status: unhealthy
Age Group: 44-78 years
Sex: M+F
Sources:
https://pubmed.ncbi.nlm.nih.gov/13080166
Sourcing

Sourcing

Vendor/AggregatorIDURL
001 Chemical
DY459469
https://www.001chemical.com/chem/10381-75-6
3B Scientific (Wuhan) Corp
3B3-061733
http://www.3bsc.com/index/pro_info.php?id=100822
AA Blocks
AA003NF8
http://www.aablocks.com/goods/Goods/detail?id=AA003NF8
abcr GmbH
AB261343
http://www.abcr.com/shop/en/AB261343
Acadechem
ACDS-034597
http://www.acadechemical.com/product/109296
Accela ChemBio Inc
SY023545
http://www.accelachem.com/cn/search.html?keyword=SY023545&attname=GoodsCode
Achemica
ACMC-20989f
http://www.achemica.com/prodinfo/?id=118906
Achemo Scientific Limited
AC-91722
http://www.achemo.com/search/?Keyword=10381-75-6
AEchem Scientific Corp., USA
AE1-002819
http://www.aechemsc.com/info_products/AE1-002819.php
AK Scientific, Inc. (AKSCI)
Z3068
http://www.aksci.com/item_detail.php?cat=Z3068
Alfa Chemistry
AP10381756
https://reagents.alfa-chemistry.com/product/8-bromotheophylline-cas-10381-75-6-955.html
Alichem
449040608
http://www.alichem.com/en/products/10381-75-6.html
Ambinter
Amb17989182
http://www.ambinter.com/reference/17989182
Anward
ANW-14977
http://www.anward.com/pro_result/20744
Anward
ANW-60462
http://www.anward.com/pro_result/46913
Aronis
ARONIS24331
http://www.aronis.ru/store/index.php?main_page=product_info&cPath=1&products_id=1467
Aurora Fine Chemicals LLC
A00.352.961
http://online.aurorafinechemicals.com/info?ID=A00.352.961
Aurora Fine Chemicals LLC
K00.380.043
http://online.aurorafinechemicals.com/info?ID=K00.380.043
Aurum Pharmatech LLC
NE22738
http://www.Aurumpharmatech.com/Product/ProductDetails/NE22738
Aurum Pharmatech LLC
W-6261
http://www.Aurumpharmatech.com/Product/ProductDetails/W_6261
Beijing Acemol Technology
AMMD00018
http://www.acemol.com/products/PAMMD00018.shtml
BioSynth
W-108837
https://www.biosynth.com/en/products/life-science/other-biochemicals/products/W-108837.html
ChemMol
80101484
http://www.chemmol.com/chemmol/80101484.html
ChemMol
97804561
http://www.chemmol.com/chemmol/97804561.html
Chemspace
CSSB00000185366
https://chem-space.com/CSSB00000185366
Clearsynth
CS-T-08990
https://www.clearsynth.com/en/CST08990.html
Debye Scientific
DB-040487
http://www.debyesci.com/cas_10381-75-6.html
Enamine
Z57161790
https://www.enaminestore.com/catalog/Z57161790
eNovation Chemicals
D547226
http://www.enovationchem.com/productDetails.asp?productID=D547226
eNovation Chemicals
D665659
https://enovationchem.com/ProductDetails.asp?ProductID=D665659
eNovation Chemicals
D912216
https://www.enovationchem.com/ProductDetails.asp?ProductID=D912216
eNovation Chemicals
Y1045702
https://www.enovationchem.com/ProductDetails.asp?ProductID=Y1045702
Finetech
FT-0636693
http://www.finetechnology-ind.com/prod/detail/pub/10381-75-6.html
Glentham Life Sciences
GK0131
http://www.glentham.com/products/product/GK0131/
Hairui
HR136666
http://www.hairuichem.com/en/product/10381-75-6.html
Hefei Hirisun Pharmatech Co., Ltd
HR130273
http://www.hirisunpharm.com/10381-75-6.html
iChemical
EBD15297
http://www.ichemical.com/products/10381-75-6.html?utm_source=PubChem&utm_medium=website&utm_campaign=product%20catalogs
Lab Network
LN00182656
https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN00182656
Matrix Scientific
84106
https://www.matrixscientific.com/084106.html
mcule
MCULE-1062341165
https://mcule.com/MCULE-1062341165/
Molcore
MC459469
https://www.molcore.com/product/10381-75-6
Oakwood
38840
http://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=32716&ExtHyperLink=1
Otava
128760678
https://search.otavachemicals.com/#!/search?query=0128760678&type=code&base=dbb
Sigma-Aldrich
S168378_ALDRICH
https://www.sigmaaldrich.com/catalog/product/aldrich/s168378
Sigma-Aldrich
S359041_ALDRICH
https://www.sigmaaldrich.com/catalog/product/aldrich/s359041
Sinfoo Biotech
S018940
http://www.sinfoobiotech.com/product/1022338
Smolecule
S589595
https://www.smolecule.com/products/s589595
TCI (Tokyo Chemical Industry)
B3456
http://www.tcichemicals.com/eshop/en/us/commodity/B3456/index.html
THE BioTek
bt-295659
https://www.thebiotek.com/product/others/bt-295659
TripleBond
CP0064
http://www.triplebond-canada.com/prod/1510/
Vesino Industrial Co Ltd
VZ35733
http://www.vsnchem.com/goto/product/44307/
VladaChem
VL260980-1G
https://www.vladachem.com/product.php?products=10381-75-6
PubMed

PubMed

TitleDatePubMed
Erythema multiforme secondary to dimenhydrinate in a patient with previous similar reactions to pamabrom.
2014-03
Fixed drug eruption caused by pamabrom.
2009-10
A study of diuretic action of pamabrom (2-amino-2-methyl-propanol-1-8-bromotheophylline) in cardiac failure.
1953-08
Patents

Patents

20040170681
2

Sample Use Guides

In Vivo Use Guide
Adults:  Take one (1) capsule after breakfast with a full glass of water.  Dose may be repeated after six (6) hours, not to exceed four (4) capsules per day. Start taking 5 or 6 days before onset of period and continue until desired relief is obtained or end of period. Drink 6 to 8 glasses of water daily.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Mon Mar 31 17:47:51 GMT 2025
Edited
by admin
on Mon Mar 31 17:47:51 GMT 2025
Record UNII
UA8U0KJM72
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
2-AMINO-2-METHYLPROPANOL-1-8-BROMOTHEOPHYLLINATE
Preferred Name English
PAMABROM
MART.   MI   USAN   USP   VANDF   WHO-DD  
USAN  
Official Name English
PAMABROM [VANDF]
Common Name English
PAMABROM [USAN]
Common Name English
Pamabrom [WHO-DD]
Common Name English
PAMABROM [MI]
Common Name English
PAMABROM [USP MONOGRAPH]
Common Name English
8-Bromotheophylline compound with 2-amino-2-methyl-1-propanol (1:1)
Systematic Name English
8-BROMO-3,7-DIHYDRO-1,3-DIMETHYL-1H-PURINE-2,6-DIONE COMPOUND WITH 2-AMINO-2-METHYL-1-PROPANOL (1:1)
Systematic Name English
PAMABROM [MART.]
Common Name English
Classification Tree Code System Code
LIVERTOX 734
Created by admin on Mon Mar 31 17:47:51 GMT 2025 , Edited by admin on Mon Mar 31 17:47:51 GMT 2025
NCI_THESAURUS C448
Created by admin on Mon Mar 31 17:47:51 GMT 2025 , Edited by admin on Mon Mar 31 17:47:51 GMT 2025
CFR 21 CFR 310.201
Created by admin on Mon Mar 31 17:47:51 GMT 2025 , Edited by admin on Mon Mar 31 17:47:51 GMT 2025
Code System Code Type Description
EPA CompTox
DTXSID80209397
Created by admin on Mon Mar 31 17:47:51 GMT 2025 , Edited by admin on Mon Mar 31 17:47:51 GMT 2025
PRIMARY
NCI_THESAURUS
C81076
Created by admin on Mon Mar 31 17:47:51 GMT 2025 , Edited by admin on Mon Mar 31 17:47:51 GMT 2025
PRIMARY
MESH
C069987
Created by admin on Mon Mar 31 17:47:51 GMT 2025 , Edited by admin on Mon Mar 31 17:47:51 GMT 2025
PRIMARY
RXCUI
54365
Created by admin on Mon Mar 31 17:47:51 GMT 2025 , Edited by admin on Mon Mar 31 17:47:51 GMT 2025
PRIMARY RxNorm
DRUG BANK
DBSALT002688
Created by admin on Mon Mar 31 17:47:51 GMT 2025 , Edited by admin on Mon Mar 31 17:47:51 GMT 2025
PRIMARY
FDA UNII
UA8U0KJM72
Created by admin on Mon Mar 31 17:47:51 GMT 2025 , Edited by admin on Mon Mar 31 17:47:51 GMT 2025
PRIMARY
CAS
606-04-2
Created by admin on Mon Mar 31 17:47:51 GMT 2025 , Edited by admin on Mon Mar 31 17:47:51 GMT 2025
PRIMARY
SMS_ID
100000079715
Created by admin on Mon Mar 31 17:47:51 GMT 2025 , Edited by admin on Mon Mar 31 17:47:51 GMT 2025
PRIMARY
WIKIPEDIA
Pamabrom
Created by admin on Mon Mar 31 17:47:51 GMT 2025 , Edited by admin on Mon Mar 31 17:47:51 GMT 2025
PRIMARY
EVMPD
SUB14745MIG
Created by admin on Mon Mar 31 17:47:51 GMT 2025 , Edited by admin on Mon Mar 31 17:47:51 GMT 2025
PRIMARY
DAILYMED
UA8U0KJM72
Created by admin on Mon Mar 31 17:47:51 GMT 2025 , Edited by admin on Mon Mar 31 17:47:51 GMT 2025
PRIMARY
ECHA (EC/EINECS)
210-103-4
Created by admin on Mon Mar 31 17:47:51 GMT 2025 , Edited by admin on Mon Mar 31 17:47:51 GMT 2025
PRIMARY
DRUG CENTRAL
2047
Created by admin on Mon Mar 31 17:47:51 GMT 2025 , Edited by admin on Mon Mar 31 17:47:51 GMT 2025
PRIMARY
ChEMBL
CHEMBL316160
Created by admin on Mon Mar 31 17:47:51 GMT 2025 , Edited by admin on Mon Mar 31 17:47:51 GMT 2025
PRIMARY
MERCK INDEX
m8371
Created by admin on Mon Mar 31 17:47:51 GMT 2025 , Edited by admin on Mon Mar 31 17:47:51 GMT 2025
PRIMARY Merck Index
PUBCHEM
11806
Created by admin on Mon Mar 31 17:47:51 GMT 2025 , Edited by admin on Mon Mar 31 17:47:51 GMT 2025
PRIMARY
Related Record Type Details
Structure of BROMOTHEOPHYLLINE
PARENT -> SALT/SOLVATE
Structure of AMINOMETHYLPROPANOL
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of BROMOTHEOPHYLLINE
ACTIVE MOIETY
NIH
NCATS
PRIVACY NOTICE
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966