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Details

Stereochemistry ACHIRAL
Molecular Formula C7H7BrN4O2.C4H11NO
Molecular Weight 348.196
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PAMABROM

SMILES

CC(C)(N)CO.CN1C2=C(N=C(Br)N2)C(=O)N(C)C1=O

InChI

InChIKey=ATOTUUBRFJHZQG-UHFFFAOYSA-N
InChI=1S/C7H7BrN4O2.C4H11NO/c1-11-4-3(9-6(8)10-4)5(13)12(2)7(11)14;1-4(2,5)3-6/h1-2H3,(H,9,10);6H,3,5H2,1-2H3

HIDE SMILES / InChI
Molecular Formula C4H11NO
Molecular Weight 89.1362
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C7H7BrN4O2
Molecular Weight 259.06
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Pamabrom is a diuretic drug, available in over-the-counter medications. The active diuretic ingredient in pamabrom is 8-bromotheophylline. It is used for the relief of temporary water weight gain; bloating; swelling; full feeling associated with the premenstrual and menstrual periods.

Approval Year

1952
115
Targets

Targets

Primary TargetPharmacologyConditionPotency
Antagonist
2778
 10.2 µM [Ki]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
Not Provided
504
DIUREX

Approved Use

Unknown
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
3685.6 ng/mL
EXPERIMENT
http://www.annexpublishers.co/full-text/JBS/3101/Bioanalytical-Method-for-Pamabrom-Determined-As-8-Bromotheophylline-and-its-Application-to-a-Pharmacokinetic-Study.php
25 mg single, oral
dose: 25 mg
route of administration: Oral
experiment type: SINGLE
co-administered: ACETAMINOPHEN
ACETAMINOPHEN
 BROMOTHEOPHYLLINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE
food status: FASTED
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
46210.49 ng × h/mL
EXPERIMENT
http://www.annexpublishers.co/full-text/JBS/3101/Bioanalytical-Method-for-Pamabrom-Determined-As-8-Bromotheophylline-and-its-Application-to-a-Pharmacokinetic-Study.php
25 mg single, oral
dose: 25 mg
route of administration: Oral
experiment type: SINGLE
co-administered: ACETAMINOPHEN
ACETAMINOPHEN
 BROMOTHEOPHYLLINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE
food status: FASTED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
21.35 h
EXPERIMENT
http://www.annexpublishers.co/full-text/JBS/3101/Bioanalytical-Method-for-Pamabrom-Determined-As-8-Bromotheophylline-and-its-Application-to-a-Pharmacokinetic-Study.php
25 mg single, oral
dose: 25 mg
route of administration: Oral
experiment type: SINGLE
co-administered: ACETAMINOPHEN
ACETAMINOPHEN
 BROMOTHEOPHYLLINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE
food status: FASTED
Doses

Doses

DosePopulationAdverse events​
25 mg 1 times / day multiple, oral
Dose: 25 mg, 1 times / day
Route: oral
Route: multiple
Dose: 25 mg, 1 times / day
Co-administed with::
2-amino-2-methyl-1-propanol
Sources:
https://pubmed.ncbi.nlm.nih.gov/19681920
unhealthy, 26 years
n = 1
Health Status: unhealthy
Age Group: 26 years
Sex: F
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/19681920
Disc. AE: Fixed drug eruption...
AEs leading to
discontinuation/dose reduction:
Fixed drug eruption
Sources:
https://pubmed.ncbi.nlm.nih.gov/19681920
900 mg 1 times / day multiple, oral
Highest studied dose
Dose: 900 mg, 1 times / day
Route: oral
Route: multiple
Dose: 900 mg, 1 times / day
Co-administed with::
2-amino-2-methyl-1-propanol
Sources:
https://pubmed.ncbi.nlm.nih.gov/13080166
unhealthy, 44-78 years
n = 1
Health Status: unhealthy
Condition: cardiac failure
Age Group: 44-78 years
Sex: M+F
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/13080166
Disc. AE: Diarrhea...
AEs leading to
discontinuation/dose reduction:
Diarrhea (mild, 1 patient)
Sources:
https://pubmed.ncbi.nlm.nih.gov/13080166
600 mg 1 times / day multiple, oral
Dose: 600 mg, 1 times / day
Route: oral
Route: multiple
Dose: 600 mg, 1 times / day
Co-administed with::
2-amino-2-methyl-1-propanol
Sources:
https://pubmed.ncbi.nlm.nih.gov/13080166
unhealthy, 44-78 years
n = 18
Health Status: unhealthy
Condition: cardiac failure
Age Group: 44-78 years
Sex: M+F
Population Size: 18
Sources:
https://pubmed.ncbi.nlm.nih.gov/13080166
Disc. AE: Nausea, Vomiting...
AEs leading to
discontinuation/dose reduction:
Nausea (severe, 4 patients)
Vomiting (severe, 4 patients)
Skin rash (1 patient)
Sources:
https://pubmed.ncbi.nlm.nih.gov/13080166
AEs

AEs

AESignificanceDosePopulation
Fixed drug eruption Disc. AE
25 mg 1 times / day multiple, oral
Dose: 25 mg, 1 times / day
Route: oral
Route: multiple
Dose: 25 mg, 1 times / day
Co-administed with::
2-amino-2-methyl-1-propanol
Sources:
https://pubmed.ncbi.nlm.nih.gov/19681920
unhealthy, 26 years
n = 1
Health Status: unhealthy
Age Group: 26 years
Sex: F
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/19681920
Diarrhea mild, 1 patient
Disc. AE
900 mg 1 times / day multiple, oral
Highest studied dose
Dose: 900 mg, 1 times / day
Route: oral
Route: multiple
Dose: 900 mg, 1 times / day
Co-administed with::
2-amino-2-methyl-1-propanol
Sources:
https://pubmed.ncbi.nlm.nih.gov/13080166
unhealthy, 44-78 years
n = 1
Health Status: unhealthy
Condition: cardiac failure
Age Group: 44-78 years
Sex: M+F
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/13080166
Skin rash 1 patient
Disc. AE
600 mg 1 times / day multiple, oral
Dose: 600 mg, 1 times / day
Route: oral
Route: multiple
Dose: 600 mg, 1 times / day
Co-administed with::
2-amino-2-methyl-1-propanol
Sources:
https://pubmed.ncbi.nlm.nih.gov/13080166
unhealthy, 44-78 years
n = 18
Health Status: unhealthy
Condition: cardiac failure
Age Group: 44-78 years
Sex: M+F
Population Size: 18
Sources:
https://pubmed.ncbi.nlm.nih.gov/13080166
Nausea severe, 4 patients
Disc. AE
600 mg 1 times / day multiple, oral
Dose: 600 mg, 1 times / day
Route: oral
Route: multiple
Dose: 600 mg, 1 times / day
Co-administed with::
2-amino-2-methyl-1-propanol
Sources:
https://pubmed.ncbi.nlm.nih.gov/13080166
unhealthy, 44-78 years
n = 18
Health Status: unhealthy
Condition: cardiac failure
Age Group: 44-78 years
Sex: M+F
Population Size: 18
Sources:
https://pubmed.ncbi.nlm.nih.gov/13080166
Vomiting severe, 4 patients
Disc. AE
600 mg 1 times / day multiple, oral
Dose: 600 mg, 1 times / day
Route: oral
Route: multiple
Dose: 600 mg, 1 times / day
Co-administed with::
2-amino-2-methyl-1-propanol
Sources:
https://pubmed.ncbi.nlm.nih.gov/13080166
unhealthy, 44-78 years
n = 18
Health Status: unhealthy
Condition: cardiac failure
Age Group: 44-78 years
Sex: M+F
Population Size: 18
Sources:
https://pubmed.ncbi.nlm.nih.gov/13080166
Sourcing

Sourcing

Vendor/AggregatorIDURL
001 Chemical
DY459469
https://www.001chemical.com/chem/10381-75-6
3B Scientific (Wuhan) Corp
3B3-061733
http://www.3bsc.com/index/pro_info.php?id=100822
AA Blocks
AA003NF8
http://www.aablocks.com/goods/Goods/detail?id=AA003NF8
AEchem Scientific Corp., USA
AE1-002819
http://www.aechemsc.com/info_products/AE1-002819.php
AK Scientific, Inc. (AKSCI)
Z3068
http://www.aksci.com/item_detail.php?cat=Z3068
Acadechem
ACDS-034597
http://www.acadechemical.com/product/109296
Accela ChemBio Inc
SY023545
http://www.accelachem.com/cn/search.html?keyword=SY023545&attname=GoodsCode
Achemica
ACMC-20989f
http://www.achemica.com/prodinfo/?id=118906
Achemo Scientific Limited
AC-91722
http://www.achemo.com/search/?Keyword=10381-75-6
Alfa Chemistry
AP10381756
https://reagents.alfa-chemistry.com/product/8-bromotheophylline-cas-10381-75-6-955.html
Alichem
449040608
http://www.alichem.com/en/products/10381-75-6.html
Ambinter
Amb17989182
http://www.ambinter.com/reference/17989182
Anward
ANW-14977
http://www.anward.com/pro_result/20744
Anward
ANW-60462
http://www.anward.com/pro_result/46913
Aronis
ARONIS24331
http://www.aronis.ru/store/index.php?main_page=product_info&cPath=1&products_id=1467
Aurora Fine Chemicals LLC
A00.352.961
http://online.aurorafinechemicals.com/info?ID=A00.352.961
Aurora Fine Chemicals LLC
K00.380.043
http://online.aurorafinechemicals.com/info?ID=K00.380.043
Aurum Pharmatech LLC
NE22738
http://www.Aurumpharmatech.com/Product/ProductDetails/NE22738
Aurum Pharmatech LLC
W-6261
http://www.Aurumpharmatech.com/Product/ProductDetails/W_6261
Beijing Acemol Technology
AMMD00018
http://www.acemol.com/products/PAMMD00018.shtml
BioSynth
W-108837
https://www.biosynth.com/en/products/life-science/other-biochemicals/products/W-108837.html
ChemMol
80101484
http://www.chemmol.com/chemmol/80101484.html
ChemMol
97804561
http://www.chemmol.com/chemmol/97804561.html
Chemspace
CSSB00000185366
https://chem-space.com/CSSB00000185366
Clearsynth
CS-T-08990
https://www.clearsynth.com/en/CST08990.html
Debye Scientific
DB-040487
http://www.debyesci.com/cas_10381-75-6.html
Enamine
Z57161790
https://www.enaminestore.com/catalog/Z57161790
Finetech
FT-0636693
http://www.finetechnology-ind.com/prod/detail/pub/10381-75-6.html
Glentham Life Sciences
GK0131
http://www.glentham.com/products/product/GK0131/
Hairui
HR136666
http://www.hairuichem.com/en/product/10381-75-6.html
Hefei Hirisun Pharmatech Co., Ltd
HR130273
http://www.hirisunpharm.com/10381-75-6.html
Lab Network
LN00182656
https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN00182656
Matrix Scientific
84106
https://www.matrixscientific.com/084106.html
Molcore
MC459469
https://www.molcore.com/product/10381-75-6
Oakwood
38840
http://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=32716&ExtHyperLink=1
Otava
128760678
https://search.otavachemicals.com/#!/search?query=0128760678&type=code&base=dbb
Sigma-Aldrich
S168378_ALDRICH
https://www.sigmaaldrich.com/catalog/product/aldrich/s168378
Sigma-Aldrich
S359041_ALDRICH
https://www.sigmaaldrich.com/catalog/product/aldrich/s359041
Sinfoo Biotech
S018940
http://www.sinfoobiotech.com/product/1022338
Smolecule
S589595
https://www.smolecule.com/products/s589595
TCI (Tokyo Chemical Industry)
B3456
http://www.tcichemicals.com/eshop/en/us/commodity/B3456/index.html
THE BioTek
bt-295659
https://www.thebiotek.com/product/others/bt-295659
TripleBond
CP0064
http://www.triplebond-canada.com/prod/1510/
Vesino Industrial Co Ltd
VZ35733
http://www.vsnchem.com/goto/product/44307/
VladaChem
VL260980-1G
https://www.vladachem.com/product.php?products=10381-75-6
abcr GmbH
AB261343
http://www.abcr.com/shop/en/AB261343
eNovation Chemicals
D547226
http://www.enovationchem.com/productDetails.asp?productID=D547226
eNovation Chemicals
D665659
https://enovationchem.com/ProductDetails.asp?ProductID=D665659
eNovation Chemicals
D912216
https://www.enovationchem.com/ProductDetails.asp?ProductID=D912216
eNovation Chemicals
Y1045702
https://www.enovationchem.com/ProductDetails.asp?ProductID=Y1045702
iChemical
EBD15297
http://www.ichemical.com/products/10381-75-6.html?utm_source=PubChem&utm_medium=website&utm_campaign=product%20catalogs
mcule
MCULE-1062341165
https://mcule.com/MCULE-1062341165/
PubMed

PubMed

TitleDatePubMed
A study of diuretic action of pamabrom (2-amino-2-methyl-propanol-1-8-bromotheophylline) in cardiac failure.
1953 Aug
Fixed drug eruption caused by pamabrom.
2009 Oct
Erythema multiforme secondary to dimenhydrinate in a patient with previous similar reactions to pamabrom.
2014 Mar
Patents

Patents

20040170681
2

Sample Use Guides

In Vivo Use Guide
Adults:  Take one (1) capsule after breakfast with a full glass of water.  Dose may be repeated after six (6) hours, not to exceed four (4) capsules per day. Start taking 5 or 6 days before onset of period and continue until desired relief is obtained or end of period. Drink 6 to 8 glasses of water daily.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:08:30 GMT 2023
Edited
by admin
on Fri Dec 15 15:08:30 GMT 2023
Record UNII
UA8U0KJM72
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PAMABROM
MART.   MI   USAN   USP   VANDF   WHO-DD  
USAN  
Official Name English
2-AMINO-2-METHYLPROPANOL-1-8-BROMOTHEOPHYLLINATE
Systematic Name English
PAMABROM [VANDF]
Common Name English
PAMABROM [USAN]
Common Name English
Pamabrom [WHO-DD]
Common Name English
PAMABROM [MI]
Common Name English
PAMABROM [USP MONOGRAPH]
Common Name English
8-Bromotheophylline compound with 2-amino-2-methyl-1-propanol (1:1)
Systematic Name English
8-BROMO-3,7-DIHYDRO-1,3-DIMETHYL-1H-PURINE-2,6-DIONE COMPOUND WITH 2-AMINO-2-METHYL-1-PROPANOL (1:1)
Systematic Name English
PAMABROM [MART.]
Common Name English
Classification Tree Code System Code
LIVERTOX 734
Created by admin on Fri Dec 15 15:08:30 GMT 2023 , Edited by admin on Fri Dec 15 15:08:30 GMT 2023
NCI_THESAURUS C448
Created by admin on Fri Dec 15 15:08:30 GMT 2023 , Edited by admin on Fri Dec 15 15:08:30 GMT 2023
CFR 21 CFR 310.201
Created by admin on Fri Dec 15 15:08:30 GMT 2023 , Edited by admin on Fri Dec 15 15:08:30 GMT 2023
Code System Code Type Description
EPA CompTox
DTXSID80209397
Created by admin on Fri Dec 15 15:08:30 GMT 2023 , Edited by admin on Fri Dec 15 15:08:30 GMT 2023
PRIMARY
NCI_THESAURUS
C81076
Created by admin on Fri Dec 15 15:08:30 GMT 2023 , Edited by admin on Fri Dec 15 15:08:30 GMT 2023
PRIMARY
MESH
C069987
Created by admin on Fri Dec 15 15:08:30 GMT 2023 , Edited by admin on Fri Dec 15 15:08:30 GMT 2023
PRIMARY
RXCUI
54365
Created by admin on Fri Dec 15 15:08:30 GMT 2023 , Edited by admin on Fri Dec 15 15:08:30 GMT 2023
PRIMARY RxNorm
DRUG BANK
DBSALT002688
Created by admin on Fri Dec 15 15:08:30 GMT 2023 , Edited by admin on Fri Dec 15 15:08:30 GMT 2023
PRIMARY
FDA UNII
UA8U0KJM72
Created by admin on Fri Dec 15 15:08:30 GMT 2023 , Edited by admin on Fri Dec 15 15:08:30 GMT 2023
PRIMARY
CAS
606-04-2
Created by admin on Fri Dec 15 15:08:30 GMT 2023 , Edited by admin on Fri Dec 15 15:08:30 GMT 2023
PRIMARY
SMS_ID
100000079715
Created by admin on Fri Dec 15 15:08:30 GMT 2023 , Edited by admin on Fri Dec 15 15:08:30 GMT 2023
PRIMARY
WIKIPEDIA
Pamabrom
Created by admin on Fri Dec 15 15:08:30 GMT 2023 , Edited by admin on Fri Dec 15 15:08:30 GMT 2023
PRIMARY
EVMPD
SUB14745MIG
Created by admin on Fri Dec 15 15:08:30 GMT 2023 , Edited by admin on Fri Dec 15 15:08:30 GMT 2023
PRIMARY
DAILYMED
UA8U0KJM72
Created by admin on Fri Dec 15 15:08:30 GMT 2023 , Edited by admin on Fri Dec 15 15:08:30 GMT 2023
PRIMARY
ECHA (EC/EINECS)
210-103-4
Created by admin on Fri Dec 15 15:08:30 GMT 2023 , Edited by admin on Fri Dec 15 15:08:30 GMT 2023
PRIMARY
DRUG CENTRAL
2047
Created by admin on Fri Dec 15 15:08:30 GMT 2023 , Edited by admin on Fri Dec 15 15:08:30 GMT 2023
PRIMARY
ChEMBL
CHEMBL316160
Created by admin on Fri Dec 15 15:08:30 GMT 2023 , Edited by admin on Fri Dec 15 15:08:30 GMT 2023
PRIMARY
MERCK INDEX
m8371
Created by admin on Fri Dec 15 15:08:30 GMT 2023 , Edited by admin on Fri Dec 15 15:08:30 GMT 2023
PRIMARY Merck Index
PUBCHEM
11806
Created by admin on Fri Dec 15 15:08:30 GMT 2023 , Edited by admin on Fri Dec 15 15:08:30 GMT 2023
PRIMARY
Related Record Type Details
Structure of BROMOTHEOPHYLLINE
PARENT -> SALT/SOLVATE
Structure of AMINOMETHYLPROPANOL
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of BROMOTHEOPHYLLINE
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