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Details

Stereochemistry ACHIRAL
Molecular Formula C7H7BrN4O2
Molecular Weight 259.06
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BROMOTHEOPHYLLINE

SMILES

CN1C2=C(NC(Br)=N2)C(=O)N(C)C1=O

InChI

InChIKey=SKTFQHRVFFOHTQ-UHFFFAOYSA-N
InChI=1S/C7H7BrN4O2/c1-11-4-3(9-6(8)10-4)5(13)12(2)7(11)14/h1-2H3,(H,9,10)

HIDE SMILES / InChI

Molecular Formula C7H7BrN4O2
Molecular Weight 259.06
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Pamabrom is a diuretic drug, available in over-the-counter medications. The active diuretic ingredient in pamabrom is 8-bromotheophylline. It is used for the relief of temporary water weight gain; bloating; swelling; full feeling associated with the premenstrual and menstrual periods.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
10.2 µM [Ki]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
DIUREX
PubMed

PubMed

TitleDatePubMed
A study of diuretic action of pamabrom (2-amino-2-methyl-propanol-1-8-bromotheophylline) in cardiac failure.
1953 Aug
Fixed drug eruption caused by pamabrom.
2009 Oct
Erythema multiforme secondary to dimenhydrinate in a patient with previous similar reactions to pamabrom.
2014 Mar
Patents

Patents

Sample Use Guides

In Vivo Use Guide
Adults:  Take one (1) capsule after breakfast with a full glass of water.  Dose may be repeated after six (6) hours, not to exceed four (4) capsules per day. Start taking 5 or 6 days before onset of period and continue until desired relief is obtained or end of period. Drink 6 to 8 glasses of water daily.
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Tue Oct 22 13:48:42 UTC 2019
Edited
by admin
on Tue Oct 22 13:48:42 UTC 2019
Record UNII
FZG87K1MQ6
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BROMOTHEOPHYLLINE
Systematic Name English
8-BROMOTHEOPHYLLINE [USP-RS]
Common Name English
NSC-164940
Code English
8-BROMOTHEOPHYLLINE
USP-RS  
Systematic Name English
1H-PURINE-2,6-DIONE, 8-BROMO-3,9-DIHYDRO-1,3-DIMETHYL-
Systematic Name English
Code System Code Type Description
PUBCHEM
11808
Created by admin on Tue Oct 22 13:48:42 UTC 2019 , Edited by admin on Tue Oct 22 13:48:42 UTC 2019
PRIMARY
RXCUI
1546386
Created by admin on Tue Oct 22 13:48:42 UTC 2019 , Edited by admin on Tue Oct 22 13:48:42 UTC 2019
PRIMARY RxNorm
CAS
10381-75-6
Created by admin on Tue Oct 22 13:48:42 UTC 2019 , Edited by admin on Tue Oct 22 13:48:42 UTC 2019
PRIMARY
ECHA (EC/EINECS)
233-846-6
Created by admin on Tue Oct 22 13:48:42 UTC 2019 , Edited by admin on Tue Oct 22 13:48:42 UTC 2019
PRIMARY
EPA CompTox
10381-75-6
Created by admin on Tue Oct 22 13:48:42 UTC 2019 , Edited by admin on Tue Oct 22 13:48:42 UTC 2019
PRIMARY
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SALT/SOLVATE -> PARENT
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SALT/SOLVATE -> PARENT
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ACTIVE MOIETY