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Details

Stereochemistry ACHIRAL
Molecular Formula C7H7BrN4O2
Molecular Weight 259.06
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BROMOTHEOPHYLLINE

SMILES

CN1C2=C(NC(Br)=N2)C(=O)N(C)C1=O

InChI

InChIKey=SKTFQHRVFFOHTQ-UHFFFAOYSA-N
InChI=1S/C7H7BrN4O2/c1-11-4-3(9-6(8)10-4)5(13)12(2)7(11)14/h1-2H3,(H,9,10)

HIDE SMILES / InChI

Molecular Formula C7H7BrN4O2
Molecular Weight 259.06
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Pamabrom is a diuretic drug, available in over-the-counter medications. The active diuretic ingredient in pamabrom is 8-bromotheophylline. It is used for the relief of temporary water weight gain; bloating; swelling; full feeling associated with the premenstrual and menstrual periods.

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
10.2 µM [Ki]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
DIUREX

Cmax

ValueDoseCo-administeredAnalytePopulation
3685.6 ng/mL
25 mg single, oral
BROMOTHEOPHYLLINE plasma
Homo sapiens

AUC

ValueDoseCo-administeredAnalytePopulation
46210.49 ng × h/mL
25 mg single, oral
BROMOTHEOPHYLLINE plasma
Homo sapiens

T1/2

ValueDoseCo-administeredAnalytePopulation
21.35 h
25 mg single, oral
BROMOTHEOPHYLLINE plasma
Homo sapiens

Doses

AEs

PubMed

Patents

Sample Use Guides

In Vivo Use Guide
Adults:  Take one (1) capsule after breakfast with a full glass of water.  Dose may be repeated after six (6) hours, not to exceed four (4) capsules per day. Start taking 5 or 6 days before onset of period and continue until desired relief is obtained or end of period. Drink 6 to 8 glasses of water daily.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Record UNII
FZG87K1MQ6
Record Status Validated (UNII)
Record Version