p-Phenylenediamine is one of the simplest aromatic diamine primarily used as a component of engineering polymers, composites, dye intermediate and as a hair dye. p-Phenylenediamine is easily oxidized, and for this reason derivatives of p-Phenylenediamine are used as antiozonants in the production of rubber products. The substituents, naphthyl, isopropyl etc. affect the effectiveness of their antioxidant roles as well as their properties as skin irritants. Acute (short-term) exposure to high levels of p-phenylenediamine may cause severe dermatitis, eye irritation and asthma, gastritis, renal failure, vertigo, tremors, convulsions, and coma in humans. Eczematoid contact dermatitis may result from chronic (long-term) exposure in humans. In rats and mice chronically exposed to p-phenylenediamine in their diet, depressed body weights, but no other clinical signs of toxicity were observed in several studies. No information is available on the reproductive, developmental, or carcinogenic effects of p-phenylenediamine in humans. EPA has not classified p-phenylenediamine with respect to carcinogenicity.

Gold monoiodide (AuI; Aurum iodatum) is a chemical compound of gold and iodine. This compound can be synthesized by heating gold and iodine in a sealed tube at 120°C for about four months. It decomposes when treated with hot water, but its related complexes are much more stable. It’s used like unapproved homeopathic product for treatment of Senile Paresis. This product is to be used for self-limiting conditions. If symptoms do not improve in 4 days, or worsen, discontinue use and seek assistance of health professional

Quaternium-15, a preservative, is one of the most used substances and is added to several cosmetics and other industrial products. Quaternium-15 is a mixture of isomers, where the cis-form is the dominant form and where the trans-form is the minor component present as an impurity. Quaternium-15 can be found under a variety of names, most commonly those of the Dow Chemical Company: Dowicil 200 (cis isomer only), Dowicil 75 and Dowicil 100 (both a mix of cis and trans isomers). The isolated cis-compound is used primarily in cosmetic applications, with a maximum permitted concentration in the EU of 0.2%. DOWICIL 200 preservative (cis form) is used primarily as a preservative in a wide variety of personal-care and cosmetic products. It is designed to provide highly effective broad-spectrum antimicrobial activity, especially in water-based formulations. It is used in both leave-on and rinse-off application such as baby-care products, hair-care products, lotions, powders, and creams. The mixed product (cis- and trans-) is used in a wider range of formulations such as: emulsifiable metal-cutting fluids; latex and emulsion paints; liquid floor polishes and floor waxes; glues and adhesives. Recently, the cis-form has been classified as a CMR substance with the classification toxic to reproduction, category 3. This classification only concerns the cis-isomer:

Diphenylguanidine (DPG) has been used as a primary and secondary accelerator in the vulcanization of rubber. Exposure to DPG may occur as a result of dermal contact during rubber manufacture or from contact with the finished products. DPG is poorly absorbed through skin. It can be found in latex gloves and other rubber products found in homes and offices. Diphenylguanidine is a standardized chemical allergen. It is used for diagnosis of contact allergy. It is a component of Carba Mix, used in the epicutaneous patch test, called T.R.U.E. TEST, approved by FDA in 1994. T.R.U.E. TEST is indicated for use as an aid in the diagnosis of allergic contact dermatitis in persons 18 years of age and older whose history suggests sensitivity to one or more of the 35 substances included on the T.R.U.E. TEST panels.

Cinnamyl alcohol (CAL, 3-phenyl-2-propen-1-ol) is found mostly in esterized form as a natural component in cinnamon oil obtained from the bark of the Cylonese cinnamon tree. Furthermore, (esterized) CAL is a component of the balsam of Peru from Myroxylon pereirae, of Styrax (balsam) from the wood of Liquidambar orientalis Miller or Liquidambar styraciflua L. and further plant extracts. The regulatory status of CAL includes approval (21 CFR 172.515) by the FDA and Generally Recognized as Safe (GRAS) as flavor ingredient [Number 2294] by the Flavor and Extract Manufacturers
Association. CAL included in the Council of Europe
s list of substances which may be used in foodstuffs. CAL have been reported as common component of food occurring mainly in a wide variety of fruits, vegetables, and spices in varying concentrations. The plant phenolic CAL is used as a fragrance ingredient and has antipyretic and antiproliferative effects. A recent report also demonstrated its vasodilatory activity.

Sodium dichromate is an inorganic compound, containing hexavalent chromium. It is highly corrosive and is a strong oxidizing agent. Sodium dichromate is mainly used to produce other chromium compounds but is also used in drilling muds, in metal treatments, in wood preservatives, in the production of dyes and organic chemicals and as a corrosion inhibitor. Sodium dichromate primarily affects the respiratory system causing ulcerations, shortness of breath, bronchitis, pneumonia, and asthma but can also affect the gastrointestinal tract, liver, kidneys and immune system. This substance is a known human carcinogen and is associated with an increased risk of developing lung cancer and cancer of the sinonasal cavity.

Tixocortol is a synthetic steroid with topical anti-inflammatory properties. In form of Tixocortol pivalate, also known as Pivalone, it is used to treat the inflammatory and allergic manifestations of the rhino-pharynx: allergic rhinitis, acute and chronic congestive rhinitis, vasomotor rhinitis. In addition, it has been shown to be a useful agent for assessing corticosteroid contact dermatitis, particularly for hydrocortisone-type derivatives. Labeled adverse effects are: itchy nose, dryness of the nasal mucosa, edema of the face mucosa, cataract, glaucoma, Cushing syndrome, skin thinning.