Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C26H38O5S |
| Molecular Weight | 462.642 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 7 / 7 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)(C)C(=O)SCC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O)C[C@]12C
InChI
InChIKey=BISFDZNIUZIKJD-XDANTLIUSA-N
InChI=1S/C26H38O5S/c1-23(2,3)22(30)32-14-20(29)26(31)11-9-18-17-7-6-15-12-16(27)8-10-24(15,4)21(17)19(28)13-25(18,26)5/h12,17-19,21,28,31H,6-11,13-14H2,1-5H3/t17-,18-,19-,21+,24-,25-,26-/m0/s1
Tixocortol is a synthetic steroid with topical anti-inflammatory properties. In form of Tixocortol pivalate, also known as Pivalone, it is used to treat the inflammatory and allergic manifestations of the rhino-pharynx: allergic rhinitis, acute and chronic congestive rhinitis, vasomotor rhinitis. In addition, it has been shown to be a useful agent for assessing corticosteroid contact dermatitis, particularly for hydrocortisone-type derivatives. Labeled adverse effects are: itchy nose, dryness of the nasal mucosa, edema of the face mucosa, cataract, glaucoma, Cushing syndrome, skin thinning.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Pattern of corticosteroid allergy in Thailand. | 2010-07-22 |
|
| [Allergic contact dermatitis due to corticosteroids: a 3-year retrospective study in a hospital skin allergy unit]. | 2009-05 |
|
| Positive patch-test reactions to propylene glycol: a retrospective cross-sectional analysis from the North American Contact Dermatitis Group, 1996 to 2006. | 2009-03-27 |
|
| Concordance of patch test results with four new TRUE test allergens compared with the same allergens from Chemotechnique. | 2009-01 |
|
| [The value of allergy survey in a retrospective series of 40 patients with burning-mouth syndrome (stomatodynia)]. | 2008-02 |
|
| [Epidemiologic surveillance of contact allergens. The "monitoring series" of IVDK (Information Network ofDermatologic Clinics for Detection and Scientific Evaluation of Contact Allergy]. | 2003-08 |
Patents
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Preferred Name | English | ||
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Official Name | English | ||
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| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
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NDF-RT |
N0000185508
Created by
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NCI_THESAURUS |
C211
Created by
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| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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TIXOCORTOL PIVALATE
Created by
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PRIMARY | |||
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CHEMBL2107112
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C152668
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63564
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PRIMARY | |||
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SUB04894MIG
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PRIMARY | |||
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55560-96-8
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PRIMARY | |||
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DTXSID30970904
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PRIMARY | |||
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15052414
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PRIMARY | |||
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6K28E35M3B
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PRIMARY | |||
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6K28E35M3B
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PRIMARY | |||
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DBSALT001131
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PRIMARY | |||
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N0000184306
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PRIMARY | Cell-mediated Immunity [PE] | ||
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Y-58
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38336
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PRIMARY | RxNorm | ||
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100000091288
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PRIMARY | |||
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N0000171131
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PRIMARY | Allergens [Chemical/Ingredient] | ||
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259-706-4
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PRIMARY | |||
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C019112
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PRIMARY | |||
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N0000175629
Created by
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PRIMARY | Increased Histamine Release [PE] | ||
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m10911
Created by
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PRIMARY | Merck Index |
ACTIVE MOIETY
METABOLITE (PARENT)
SUBSTANCE RECORD
