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Details

Stereochemistry ABSOLUTE
Molecular Formula C26H38O5S
Molecular Weight 462.642
Optical Activity UNSPECIFIED
Defined Stereocenters 7 / 7
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TIXOCORTOL PIVALATE

SMILES

[H][C@@]12CC[C@](O)(C(=O)CSC(=O)C(C)(C)C)[C@@]1(C)C[C@H](O)[C@@]3([H])[C@@]2([H])CCC4=CC(=O)CC[C@]34C

InChI

InChIKey=BISFDZNIUZIKJD-XDANTLIUSA-N
InChI=1S/C26H38O5S/c1-23(2,3)22(30)32-14-20(29)26(31)11-9-18-17-7-6-15-12-16(27)8-10-24(15,4)21(17)19(28)13-25(18,26)5/h12,17-19,21,28,31H,6-11,13-14H2,1-5H3/t17-,18-,19-,21+,24-,25-,26-/m0/s1

HIDE SMILES / InChI
Molecular Formula C26H38O5S
Molecular Weight 462.642
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 7 / 7
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Tixocortol is a synthetic steroid with topical anti-inflammatory properties. In form of Tixocortol pivalate, also known as Pivalone, it is used to treat the inflammatory and allergic manifestations of the rhino-pharynx: allergic rhinitis, acute and chronic congestive rhinitis, vasomotor rhinitis. In addition, it has been shown to be a useful agent for assessing corticosteroid contact dermatitis, particularly for hydrocortisone-type derivatives. Labeled adverse effects are: itchy nose, dryness of the nasal mucosa, edema of the face mucosa, cataract, glaucoma, Cushing syndrome, skin thinning.

Approval Year

1994
149
Targets

Targets

Primary TargetPharmacologyConditionPotency
Agonist
2678
PubMed

PubMed

TitleDatePubMed
Patents

Patents

JP2011518796A
15

Sample Use Guides

In Vivo Use Guide
1 to 2 sprays of 1 % Suspension in each nostril 2 to 4 times daily.
Route of Administration: Nasal
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:01:32 GMT 2023
Edited
by admin
on Fri Dec 15 15:01:32 GMT 2023
Record UNII
6K28E35M3B
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TIXOCORTOL PIVALATE
MART.   USAN   VANDF   WHO-DD  
USAN  
Official Name English
TIXOCORTOL 21-PIVALATE
MI  
Common Name English
TIXOCORTOL 21-PIVALATE [MI]
Common Name English
TIXOCORTOL PIVALATE [VANDF]
Common Name English
11β,17-Dihydroxy-21-mercaptopregn-4-ene-3,20-dione 21-pivalate
Common Name English
JO-1016
Code English
TIXOCORTOL PIVALATE [USAN]
Common Name English
PREGN-4-ENE-3,20-DIONE, 21-((2,2-DIMETHYL-1-OXOPROPYL)THIO)-11,17-DIHYDROXY-, (11.BETA.)-
Systematic Name English
TIXOCORTOL PIVALATE [MART.]
Common Name English
TIXOCORTOL-21-PIVALATE
Common Name English
Tixocortol pivalate [WHO-DD]
Common Name English
Classification Tree Code System Code
NDF-RT N0000185508
Created by admin on Fri Dec 15 15:01:32 GMT 2023 , Edited by admin on Fri Dec 15 15:01:32 GMT 2023
NCI_THESAURUS C211
Created by admin on Fri Dec 15 15:01:32 GMT 2023 , Edited by admin on Fri Dec 15 15:01:32 GMT 2023
Code System Code Type Description
WIKIPEDIA
TIXOCORTOL PIVALATE
Created by admin on Fri Dec 15 15:01:32 GMT 2023 , Edited by admin on Fri Dec 15 15:01:32 GMT 2023
PRIMARY
ChEMBL
CHEMBL2107112
Created by admin on Fri Dec 15 15:01:32 GMT 2023 , Edited by admin on Fri Dec 15 15:01:32 GMT 2023
PRIMARY
NCI_THESAURUS
C152668
Created by admin on Fri Dec 15 15:01:32 GMT 2023 , Edited by admin on Fri Dec 15 15:01:32 GMT 2023
PRIMARY
CHEBI
63564
Created by admin on Fri Dec 15 15:01:32 GMT 2023 , Edited by admin on Fri Dec 15 15:01:32 GMT 2023
PRIMARY
EVMPD
SUB04894MIG
Created by admin on Fri Dec 15 15:01:32 GMT 2023 , Edited by admin on Fri Dec 15 15:01:32 GMT 2023
PRIMARY
CAS
55560-96-8
Created by admin on Fri Dec 15 15:01:32 GMT 2023 , Edited by admin on Fri Dec 15 15:01:32 GMT 2023
PRIMARY
EPA CompTox
DTXSID30970904
Created by admin on Fri Dec 15 15:01:32 GMT 2023 , Edited by admin on Fri Dec 15 15:01:32 GMT 2023
PRIMARY
PUBCHEM
15052414
Created by admin on Fri Dec 15 15:01:32 GMT 2023 , Edited by admin on Fri Dec 15 15:01:32 GMT 2023
PRIMARY
DAILYMED
6K28E35M3B
Created by admin on Fri Dec 15 15:01:32 GMT 2023 , Edited by admin on Fri Dec 15 15:01:32 GMT 2023
PRIMARY
FDA UNII
6K28E35M3B
Created by admin on Fri Dec 15 15:01:32 GMT 2023 , Edited by admin on Fri Dec 15 15:01:32 GMT 2023
PRIMARY
DRUG BANK
DBSALT001131
Created by admin on Fri Dec 15 15:01:32 GMT 2023 , Edited by admin on Fri Dec 15 15:01:32 GMT 2023
PRIMARY
NDF-RT
N0000184306
Created by admin on Fri Dec 15 15:01:32 GMT 2023 , Edited by admin on Fri Dec 15 15:01:32 GMT 2023
PRIMARY Cell-mediated Immunity [PE]
USAN
Y-58
Created by admin on Fri Dec 15 15:01:32 GMT 2023 , Edited by admin on Fri Dec 15 15:01:32 GMT 2023
PRIMARY
RXCUI
38336
Created by admin on Fri Dec 15 15:01:32 GMT 2023 , Edited by admin on Fri Dec 15 15:01:32 GMT 2023
PRIMARY RxNorm
SMS_ID
100000091288
Created by admin on Fri Dec 15 15:01:32 GMT 2023 , Edited by admin on Fri Dec 15 15:01:32 GMT 2023
PRIMARY
NDF-RT
N0000171131
Created by admin on Fri Dec 15 15:01:32 GMT 2023 , Edited by admin on Fri Dec 15 15:01:32 GMT 2023
PRIMARY Allergens [Chemical/Ingredient]
ECHA (EC/EINECS)
259-706-4
Created by admin on Fri Dec 15 15:01:32 GMT 2023 , Edited by admin on Fri Dec 15 15:01:32 GMT 2023
PRIMARY
MESH
C019112
Created by admin on Fri Dec 15 15:01:32 GMT 2023 , Edited by admin on Fri Dec 15 15:01:32 GMT 2023
PRIMARY
NDF-RT
N0000175629
Created by admin on Fri Dec 15 15:01:32 GMT 2023 , Edited by admin on Fri Dec 15 15:01:32 GMT 2023
PRIMARY Increased Histamine Release [PE]
MERCK INDEX
m10911
Created by admin on Fri Dec 15 15:01:32 GMT 2023 , Edited by admin on Fri Dec 15 15:01:32 GMT 2023
PRIMARY Merck Index
Related Record Type Details
Structure of 3.ALPHA.,11.BETA.,17.ALPHA.-TRIHYDROXY-5.BETA.-PREGNAN-20-ONE
METABOLITE -> PARENT
IN-VIVO
URINE
Related Record Type Details
Structure of TIXOCORTOL
ACTIVE MOIETY
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
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