TIXOCORTOL

US Approved Allergenic Extract (1994)

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C21H30O4S
Molecular Weight	378.525
Optical Activity	UNSPECIFIED
Defined Stereocenters	7 / 7
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12CC[C@](O)(C(=O)CS)[C@@]1(C)C[C@H](O)[C@@]3([H])[C@@]2([H])CCC4=CC(=O)CC[C@]34C

InChI

InChIKey=YWDBSCORAARPPF-VWUMJDOOSA-N

InChI=1S/C21H30O4S/c1-19-7-5-13(22)9-12(19)3-4-14-15-6-8-21(25,17(24)11-26)20(15,2)10-16(23)18(14)19/h9,14-16,18,23,25-26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C21H30O4S
Molecular Weight	378.525
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	7 / 7
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9591812 | http://www.doctissimo.fr/medicament-PIVALONE.htm | https://www.onmeda.fr/medicament/pivalone-93206110.html

Tixocortol is a synthetic steroid with topical anti-inflammatory properties. In form of Tixocortol pivalate, also known as Pivalone, it is used to treat the inflammatory and allergic manifestations of the rhino-pharynx: allergic rhinitis, acute and chronic congestive rhinitis, vasomotor rhinitis. In addition, it has been shown to be a useful agent for assessing corticosteroid contact dermatitis, particularly for hydrocortisone-type derivatives. Labeled adverse effects are: itchy nose, dryness of the nasal mucosa, edema of the face mucosa, cataract, glaucoma, Cushing syndrome, skin thinning.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Glucocorticoid receptor 172 Target ID: CHEMBL3144 Sources: https://www.ncbi.nlm.nih.gov/pubmed/3136624\|https://www.drugbank.ca/drugs/DB09091\|https://www.genome.jp/dbget-bin/www_bget?dr:D06171	Agonist 2678

PubMed

Title	Date	PubMed
[Epidemiologic surveillance of contact allergens. The "monitoring series" of IVDK (Information Network ofDermatologic Clinics for Detection and Scientific Evaluation of Contact Allergy].	2003 Aug	12942188
Positive patch-test reactions to propylene glycol: a retrospective cross-sectional analysis from the North American Contact Dermatitis Group, 1996 to 2006.	2009 Jan-Feb	19321115
[Allergic contact dermatitis due to corticosteroids: a 3-year retrospective study in a hospital skin allergy unit].	2009 May	19463232
Pattern of corticosteroid allergy in Thailand.	2010 Jul-Aug	20646671

Patents

Sample Use Guides

In Vivo Use Guide

1 to 2 sprays of 1 % Suspension in each nostril 2 to 4 times daily.

Route of Administration: Nasal

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:56:09 GMT 2023` Edited by `admin` on `Fri Dec 15 16:56:09 GMT 2023`
Record UNII	ZX3KEK657Z
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TIXOCORTOL

Official Name

English

11.BETA.,17-DIHYDROXY-21-MERCAPTOPREGN-4-ENE-3,20-DIONE

Systematic Name

English

TIXOCORTOL [VANDF]

Common Name

English

tixocortol [INN]

Common Name

English

TIXOCORTOL [MI]

Common Name

English

CORTISOL 21-THIOL

Common Name

English

PROGESTERONE, 11.BETA.,17-DIHYDROXY-21-MERCAPTO-

Common Name

English

11.BETA.,17.ALPHA.-DIHYDROXY-21-THIO-3,20-DIOXO-4-PREGNENE

Common Name

English

PREGN-4-ENE-3,20-DIONE, 11,17-DIHYDROXY-21-MERCAPTO-, (11.BETA.)-

Systematic Name

English

Tixocortol [WHO-DD]

Common Name

English

Classification Tree Code System Code

WHO-ATC

A07EA05