Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C13H13N3.C8H6O4 |
| Molecular Weight | 377.3933 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)C1=CC=CC=C1C(O)=O.N=C(NC2=CC=CC=C2)NC3=CC=CC=C3
InChI
InChIKey=JSCFNQDWXBNVBP-UHFFFAOYSA-N
InChI=1S/C13H13N3.C8H6O4/c14-13(15-11-7-3-1-4-8-11)16-12-9-5-2-6-10-12;9-7(10)5-3-1-2-4-6(5)8(11)12/h1-10H,(H3,14,15,16);1-4H,(H,9,10)(H,11,12)
DescriptionCurator's Comment: Description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/11965241
Curator's Comment: Description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/11965241
Diphenylguanidine (DPG) has been used as a primary and secondary accelerator in the vulcanization of rubber. Exposure to DPG may occur as a result of dermal contact during rubber manufacture or from contact with the finished products. DPG is poorly absorbed through skin. It can be found in latex gloves and other rubber products found in homes and offices. Diphenylguanidine is a standardized chemical allergen. It is used for diagnosis of contact allergy. It is a component of Carba Mix, used in the epicutaneous patch test, called T.R.U.E. TEST, approved by FDA in 1994. T.R.U.E. TEST is indicated for use as an aid in the diagnosis of allergic contact dermatitis in persons 18 years of age and older whose history suggests sensitivity to one or more of the 35 substances included on the T.R.U.E. TEST panels.
Approval Year
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Diagnostic | T.R.U.E. TEST Approved UseT.R.U.E. TEST is an epicutaneous patch test indicated for use as an aid in the diagnosis of allergic contact dermatitis in persons 18 years of age and older whose history suggests sensitivity to one or more of the 35 substances included on the T.R.U.E. TEST panels. Launch Date1993 |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Occupational rubber glove allergy: results of the Information Network of Departments of Dermatology (IVDK), 1995-2001. | 2003 Jan |
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| Simultaneous sodium lauryl sulphate testing improves the diagnostic validity of allergic patch tests. Results from a prospective multicentre study of the German Contact Dermatitis Research Group (Deutsche Kontaktallergie-Gruppe, DKG). | 2005 Apr |
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| Glove allergy due to 1,3-diphenylguanidine. | 2006 Jan |
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| Identification of an unknown extraneous contaminant in pharmaceutical product analysis. | 2007 Dec 21 |
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| Novel tailoring reaction for two adjacent coordinated nitriles giving platinum 1,3,5-triazapentadiene complexes. | 2008 Dec 15 |
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| Study of molecularly imprinted solid-phase extraction of diphenylguanidine and its structural analogs. | 2009 Apr 20 |
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| A novel reactivity mode for metal-activated dialkylcyanamide species: addition of N,N'-diphenylguanidine to a cis-(R2NCN)2Pt(II) center giving an eight-membered chelated platinaguanidine. | 2009 Mar 16 |
|
| An 8-year retrospective review of patch testing with rubber allergens: the Mayo Clinic experience. | 2010 Jan-Feb |
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| Lymphomatoid allergic contact dermatitis mimicking cutaneous T cell lymphoma. | 2010 Jul-Aug |
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| Allergic contact dermatitis to synthetic rubber gloves: changing trends in patch test reactions to accelerators. | 2010 Sep |
|
| Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. | 2011 Jul 14 |
|
| Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels. | 2011 May 1 |
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DTXSID60612123
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17573-13-6
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QN8EL2P69Q
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22497391
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SUBSTANCE RECORD
