Enpromate is an antineoplastic agent.

A radioconjugate of synthetic active thyroid hormone, liothyronine (T3), labeled with Iodine 125. Liothyronine involves many important metabolic functions and is essential to the proper development and differentiation of all cells. I-125 liothyronine may be used in radiotherapy in thyroid cancers. It was used for the thyroxine T4 determination in serum by competitive protein-binding analysis.

The synthetic steroid nivazol lacks three of the substituents considered to be important for glucocorticoid activity, i.e. the 3-keto, the 11-hydroxy, and the 20-keto groups. Nevertheless, in the rat, nivazol has the activity profile of a glucocorticoid. Nivazol elicits numerous glucocorticoid activities in the rodent, but only the inhibition of the hypothalamic-pituitary-adrenal axis was observed in the primate. Nivazol has been investigated with respect to the treatment of Cushing's disease. In a patient with Nelson's syndrome nivazol was clearly highly effective in decreasing plasma ACTH concentrations and pigmentation. Its mechanism of action is similar to that of hydrocortisone. Both steroids directly inhibit in vitro ACTH secretion from corticotroph tumour cells removed from patients with Nelson's syndrome and block stimulation of ACTH release by ovine corticotrophin releasing factor and arginine vasopressin.

Pentrinitrol is a metabolite of pentaerythritol tetranitrate. It has been introduced as an antianginal agent for man. Pentrinitrol decrease myocardial oxygen consumption and have a relatively long duration of action. The pharmacologic effects of pentrinitrol are similar to those of nitroglycerin. However, the duration of action of pentrinitrol is longer. Pentrinitrol produced lower pre-exercise systolic blood pressures and systolic blood pressures at point of angina. Pentrinitrol should permit patients to have fewer episodes of angina pectoris resulting from minor increases in physical activity. The same protection may also exist against angina pectoris produced by psychic stress. However, patients should still be cautioned against physical activity or psychic stress that ordinarily provokes angina pectoris.

Epostane (WIN-32729) a pure competitive inhibitor of 3-beta-hydroxysteroid dehydrogenase. Epostane blocks progesterone synthesis during the luteal phase and in pregnancy in women and has strong anti-steroidogenic effect in endocrine tissues. Epostane is an abortifacient agent in early human pregnancy. It inhibits ovarian follicular steroidogenesis and ovulation.

Oxagrelate (also known as EG626) is an inhibitor of cAMP phosphodiesterase and lead to the platelet aggregation inhibition. Oxagrelate was studied as a smooth muscle relaxant. Information about the further development of this drug is not available.

Triflumidate is a fluoroalkanesulfonanilide. It had been identified for clinical trials. This non-steroidal compound is an anti-inflammatory agent.

Dioxation is an organophosphorous insecticide. It is a narrow-spectrum insecticide and acaricide with long residual effectiveness. The technical product is a mixture of cis and trans isomers and the oxygen analog of dioxation is relatively unstable. Dioxation is used as a spray to control mites on cotton, grapes, citrus, ornamentals, and certain other fruits including apples, pears, and quinces; and as a spray or dip on cattle, goats, sheep, and hogs for control of ticks, lice, horn flies, and sheep ked. Dietary administration of dioxation was not carcinogenic in Osborne-Mendel rats or B6C3F1 mice. Dioxation has moderate to extreme acute toxicity in mammal species tested and is moderately toxic to birds.

Diftalone is a symmetrical tetracyclic compound with anti-inflammatory and antipyretic activities. The anti-inflammatory potency of diftalone is greater than that of aspirin, approximately equal to that of phenylbutazone, but lower than that of indomethacin. Diftalone exhibited limited but statistically significant antipyretic activities. It less potent than aspirin or phenylbutazone. Diftalone seems to be an effective and safe anti-inflammatory agent in the treatment of rheumatoid arthritis. It demonstrated the same activity as indomethacin and phenylbutazone. However, because of hepatotoxicity and carcinogenicity (hepatoma) in preclinical studies and hemotoxicity and gastrointestinal adverse effects in humans, diftalone was withdrawn by its manufacturer.

Probarbital is ethylisopropylbarbituric acid patented by Thorp, L as hypnotic and sedative agent.