U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 911 - 920 of 2596 results

Status:
Other

Class (Stereo):
CHEMICAL (RACEMIC)

Conditions:

4-Hydroxyphenyglycine is a racemic mixture of L and D forms. The L form is biologically active and is also known as Oxfenicine. Formation of the racemic mixture proceeds the separation and preparation of individual enantiomers.
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Zinc decanoate has being patented as a feed additive and a feed-use growth promoter. It might be used in pig feed as a substitute for a high dose of zinc oxide; zinc decanoate reduces the use of zinc in animal husbandry and can decrease production costs, while also reducing the toxic side effects of high levels of zinc. Zinc decanoate is used as a drier in paints, dispersing agent, emulsifying agent, lubricant.
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Zinc Benzoate is an organic metal salt in a white powder form. It is very slightly soluble in water. Zinc Benzoate is commonly used in food and feed additives as a preservative and source of zinc. It is antiseptic, anti-animalcule and anti-freezing agent used in food, medicine, tobacco, plating, printing and dyeing.
Potassium tetrachloroplatinate is used in the preparation of platinum (Pt) nanoparticles. Ligands like ammonia or triphenyl phosphine can able to replace the chloride ligands to afford various derivatives. The replacement by ammonia results in the preparation of cisplatin, which is used in the cancer treatment. Further, it is used as catalyst in the hydroarylation reaction. Cisplatin and potassium tetrachloroplatinate are shown to bind to DNA that encapsulates SWNTs in aqueous solution. The bound platinum salt can then be reduced to decorate the DNA-encapsulated SWNTs with platinum nanoparticles. The unique combination of catalytic activity of nanoscale platinum, biological functionality of DNA, and optoelectronic properties of SWNTs suggests a myriad of applications including fuel cells, catalysts, biosensors, and electrochemical devices.
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Urea nitrate is a powerful explosive. It has not found use as a legitimate explosive but is commonly used as an improvised explosive.
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Ferric acetylacetonate, often abbreviated Fe(acac)3, is a ferric coordination complex featuring acetylacetonate (acac) ligands. Fe(acac)3 has been examined as a precatalyst and reagent in organic chemistry. Can be used as a catalyst in preparation, degradation, and calcification of biodegradable polyurethane foams for bone graft substitutes. Thermal decomposition of Fe(acac)(3) in triethylene glycol has being used in the synthesis of water-stable magnetite nanoparticles for clinical MRI and magnetic hyperthermia applications.
Terreic acid is a metabolite with antibiotic properties produced by the fungus Aspergillus terreus. It was found, that terreic acid inactivated UDP-N-acetylglucosamine 1-carboxyvinyltransferase (MurA), a bacterial cell wall biosynthetic enzyme, by covalently attaching to Cys115. This compound also inhibits the catalytic activity of BTK (Bruton's tyrosine kinase) and the interaction of Btk with protein kinase C beta type (PKCβII) without affecting the activity of PKC.
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

3,4,5-trimethoxy-cinnamaldehyde (TMCA) caused nasal tumors in rats. These results can be important and may have some bearing on the high incidence of nasal tumors among woodworkers. Though it is not known whether TMCA as such is present in wood lignins, it may be formed metabolically in the animal body by the action of O-methyl-transferase from its phenolic congeners.
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)


Conditions:

Retrorsine (RTS) is a naturally occurring pyrrolizidine alkaloid (PA), isolated from Senecio retrorsus of South African origin. Retrorsine is a hepatotoxic Pyrrolizidine alkaloid which specifically inhibits the proliferation of hepatocytes and subsequently induces liver injury. The toxic effect of PAs has received plentiful clinical attention, yet the understanding of the mechanism of Retrorsine-induced hepatotoxicity is still limited. It has been reported that the CYPs mediated bioactivation is necessary for the toxicity of PAs and that CYP3A4 is the major isoform involved in the metabolism of Retrorsine. Together withCYP3A4, Organic cation transporter 1 mediates the liver-specific uptake of Retrorsine and plays an important role in RTS-induced hepatotoxicity. Retrorsine impairs liver regeneration after partial hepatectomy, not only by an S or G2/M phase block but also by a block located before the G1/S transition of the cell cycle. Treatment of rats with retrorsine, a pyrrolizidine alkaloid, results in a series of chronic and progressive hepatic lesions, including a long-lasting block in the cell cycle.
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Pyridoxine-phosphate is a vitamer of Vitamin B6. In man vitamin B(6) ingested from the diet exists as six different vitamers, pyridoxal (PL), pyridoxamine (PM), pyridoxine (PN), pyridoxal 5'-phosphate (PLP), pyridoxamine 5'- phosphate (PMP) and pyridoxine 5'-phosphate (PNP). It is a substrate for pyridoxine-5'-phosphate oxidase (PNPO) and pyridoxal phosphate phosphatase (PDXP). PNPO deficiency is responsible of severe neonatal encephalopathy.