U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula 2C7H5O2.Zn
Molecular Weight 307.636
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ZINC BENZOATE

SMILES

[Zn++].[O-]C(=O)C1=CC=CC=C1.[O-]C(=O)C2=CC=CC=C2

InChI

InChIKey=JDLYKQWJXAQNNS-UHFFFAOYSA-L
InChI=1S/2C7H6O2.Zn/c2*8-7(9)6-4-2-1-3-5-6;/h2*1-5H,(H,8,9);/q;;+2/p-2

HIDE SMILES / InChI

Description

Zinc Benzoate is an organic metal salt in a white powder form. It is very slightly soluble in water. Zinc Benzoate is commonly used in food and feed additives as a preservative and source of zinc. It is antiseptic, anti-animalcule and anti-freezing agent used in food, medicine, tobacco, plating, printing and dyeing.

CNS Activity

CNS Active
3913
Curator's Comment: Zinc benzoate, which inhibits MAO-A activity, is easily incorporated in DDI water by boiling polystyrene and also may be a contaminating environmental chemical compound that alters the levels of serotonin and norepinephrine in the central nervous system. Demonstrated in monkeys.

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8297
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
PubMed

PubMed

TitleDatePubMed
Zinc benzoate, a contaminating environmental compound derived from polystyrene resin inhibits A-type monoamine oxidase.
2003 Nov 30
Synthesis of inorganic-organic layered compounds using immiscible liquid-liquid systems under the distribution law.
2010 Oct 19
Patents

Patents

CA2154860A1
1
JPH069502A
1
JPS59232146A
1

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
The effects of zinc benzoate at concentrations of 0.01–10ug/ml on MAO activity in the mitochondria of monkey brain were studied in vitro. The MAO-A activity was inhibited dose-dependently with 5-HT as substrate, and the residual activity of MAO-A was about 10% in the presence of 10ug/ml of zinc benzoate.
Name Type Language
ZINC BENZOATE
Systematic Name English
BENZOIC ACID, ZINC SALT
Common Name English
NSC-176118
Code English
Code System Code Type Description
CAS
553-72-0
Created by admin on Fri Dec 15 19:48:29 GMT 2023 , Edited by admin on Fri Dec 15 19:48:29 GMT 2023
PRIMARY
FDA UNII
6S1JO8U0CK
Created by admin on Fri Dec 15 19:48:29 GMT 2023 , Edited by admin on Fri Dec 15 19:48:29 GMT 2023
PRIMARY
NSC
176118
Created by admin on Fri Dec 15 19:48:29 GMT 2023 , Edited by admin on Fri Dec 15 19:48:29 GMT 2023
PRIMARY
ECHA (EC/EINECS)
209-047-3
Created by admin on Fri Dec 15 19:48:29 GMT 2023 , Edited by admin on Fri Dec 15 19:48:29 GMT 2023
PRIMARY
EPA CompTox
DTXSID00890504
Created by admin on Fri Dec 15 19:48:29 GMT 2023 , Edited by admin on Fri Dec 15 19:48:29 GMT 2023
PRIMARY
PUBCHEM
160523
Created by admin on Fri Dec 15 19:48:29 GMT 2023 , Edited by admin on Fri Dec 15 19:48:29 GMT 2023
PRIMARY
PARENT (SALT/SOLVATE)
Structure of Benzoic acid
PARENT (SALT/SOLVATE)
Structure of ZINC CATION
SUBSTANCE RECORD
Structure of ZINC BENZOATE
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966