PYRIDOXINE PHOSPHATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C8H12NO6P
Molecular Weight	249.1577
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=NC=C(COP(O)(O)=O)C(CO)=C1O

InChI

InChIKey=WHOMFKWHIQZTHY-UHFFFAOYSA-N

InChI=1S/C8H12NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2,10-11H,3-4H2,1H3,(H2,12,13,14)

HIDE SMILES / InChI

Molecular Formula	C8H12NO6P
Molecular Weight	249.1577
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/29379851 | https://www.ncbi.nlm.nih.gov/pubmed/22854025 | https://www.ncbi.nlm.nih.gov/pubmed/22576361

Pyridoxine-phosphate is a vitamer of Vitamin B6. In man vitamin B(6) ingested from the diet exists as six different vitamers, pyridoxal (PL), pyridoxamine (PM), pyridoxine (PN), pyridoxal 5'-phosphate (PLP), pyridoxamine 5'- phosphate (PMP) and pyridoxine 5'-phosphate (PNP). It is a substrate for pyridoxine-5'-phosphate oxidase (PNPO) and pyridoxal phosphate phosphatase (PDXP). PNPO deficiency is responsible of severe neonatal encephalopathy.

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Pyridoxine-5'-phosphate oxidase 2 Target ID: CHEMBL3271932 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6244277 \| https://www.ncbi.nlm.nih.gov/pubmed/3114257 \| https://www.ncbi.nlm.nih.gov/pubmed/29379851	Substrate 661
Pyridoxal phosphate phosphatase 1 Target ID: Q96GD0 Gene ID: 57026.0 Gene Symbol: PDXP Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/18256491 \| https://www.ncbi.nlm.nih.gov/pubmed/22854025	Substrate 661

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2596

PubMed

Title	Date	PubMed
A genomic perspective on the potential of Actinobacillus succinogenes for industrial succinate production.	2010-11-30	21118570
Pyridoxine-dependent epilepsy and pyridoxine phosphate oxidase deficiency: unique clinical symptoms and non-specific EEG characteristics.	2010-07	20412262
Seizures and paroxysmal events: symptoms pointing to the diagnosis of pyridoxine-dependent epilepsy and pyridoxine phosphate oxidase deficiency.	2010-07	20370816
Proteomic analysis of aging brain in SAMP10 mouse: a model of age-related cerebral degeneration.	2010-06	20471994
Inherited glutathione reductase deficiency and Plasmodium falciparum malaria--a case study.	2009-10-06	19806191
Enhanced pyridoxal 5'-phosphate synthetic enzyme immunoreactivities do not contribute to GABAergic inhibition in the rat hippocampus following pilocarpine-induced status epilepticus.	2009-03-31	19356691
Pyridoxine 5'-phosphate oxidase, not pyridoxal kinase, involves in long-term potentiation induction in the rat dentate gyrus.	2009-01	18680158
Pyridoxal phosphate-dependent neonatal epileptic encephalopathy.	2009	21686393
Identification of non-Alzheimer's disease tauopathies-related proteins by proteomic analysis.	2008-07	18647502
Human brain pyridoxal-5'-phosphate phosphatase (PLPP):protein transduction of PEP-1-PLPP into PC12 cells.	2008-05-31	18510874
Potential role of pyridoxal-5'-phosphate phosphatase/chronopin in epilepsy.	2008-05	18346735
The assembly of the plasmodial PLP synthase complex follows a defined course.	2008-03-19	18350152
Pyridoxal phosphate-dependent neonatal epileptic encephalopathy.	2008-03	18296573
Genome-based construction of the metabolic pathways of Orientia tsutsugamushi and comparative analysis within the Rickettsiales order.	2008	18528528
Vitamin B6 related epilepsy during childhood.	2007-12-08	18062169
Time course of changes in pyridoxal 5'-phosphate (vitamin B6 active form) and its neuroprotection in experimental ischemic damage.	2007-07	17531224
Purification and characterization of pyridoxine 5'-phosphate phosphatase from Sinorhizobium meliloti.	2005-12	16377884
[A preliminary proteomic analysis of tauopathies].	2005-05	16009011
Structure of the phenazine biosynthesis enzyme PhzG.	2004-11	15502343
Dietary antioxidant lack, impaired hepatic glutathione reserve, and cholesterol gallstones.	2004-11	15469869
Vigabatrin inhibits pyridoxine-5'-phosphate oxidase, not pyridoxal kinase in the hippocampus of seizure prone gerbils.	2004-02	14568555
Multistate binding in pyridoxine 5'-phosphate synthase: 1.96 A crystal structure in complex with 1-deoxy-D-xylulose phosphate.	2002-10-01	12269807
Chronological changes in pyridoxine-5'-phosphate oxidase immunoreactivity in the seizure-sensitive gerbil hippocampus.	2002-06-15	12111839
Immunohistochemical studies of brain pyridoxine-5'-phosphate oxidase.	2002-01-25	11792364
CSF glutamate/GABA concentrations in pyridoxine-dependent seizures: etiology of pyridoxine-dependent seizures and the mechanisms of pyridoxine action in seizure control.	2001-03	11226725

Patents

Sample Use Guides

In Vivo Use Guide

Single injection of 10 ug of pyridoxine-phosphate.

Route of Administration: Intravenous

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:56:01 GMT 2025` Edited by `admin` on `Mon Mar 31 19:56:01 GMT 2025`
Record UNII	RG20W8WYLS
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PYRIDOXINE PHOSPHATE

Common Name

English

NSC-83119

Preferred Name

English

VITAMIN B6 (PYRIDOXINE PHOSPHATE)

Common Name

English

Pyridoxine phosphate [WHO-DD]

Common Name

English

PYRIDOXINE 5-PHOSPHATE

Common Name

English

3,4-PYRIDINEDIMETHANOL, 5-HYDROXY-6-METHYL-, .ALPHA.3-(DIHYDROGEN PHOSPHATE)

Systematic Name

English

Code System Code Type Description

FDA UNII

RG20W8WYLS