PYRIDOXINE PHOSPHATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C8H12NO6P
Molecular Weight	249.1577
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=NC=C(COP(O)(O)=O)C(CO)=C1O

InChI

InChIKey=WHOMFKWHIQZTHY-UHFFFAOYSA-N

InChI=1S/C8H12NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2,10-11H,3-4H2,1H3,(H2,12,13,14)

HIDE SMILES / InChI

Molecular Formula	C8H12NO6P
Molecular Weight	249.1577
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/29379851 | https://www.ncbi.nlm.nih.gov/pubmed/22854025 | https://www.ncbi.nlm.nih.gov/pubmed/22576361

Pyridoxine-phosphate is a vitamer of Vitamin B6. In man vitamin B(6) ingested from the diet exists as six different vitamers, pyridoxal (PL), pyridoxamine (PM), pyridoxine (PN), pyridoxal 5'-phosphate (PLP), pyridoxamine 5'- phosphate (PMP) and pyridoxine 5'-phosphate (PNP). It is a substrate for pyridoxine-5'-phosphate oxidase (PNPO) and pyridoxal phosphate phosphatase (PDXP). PNPO deficiency is responsible of severe neonatal encephalopathy.

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Pyridoxine-5'-phosphate oxidase 1 Target ID: CHEMBL3271932 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6244277 \| https://www.ncbi.nlm.nih.gov/pubmed/3114257 \| https://www.ncbi.nlm.nih.gov/pubmed/29379851	Substrate 661
Pyridoxal phosphate phosphatase 1 Target ID: Q96GD0 Gene ID: 57026.0 Gene Symbol: PDXP Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/18256491 \| https://www.ncbi.nlm.nih.gov/pubmed/22854025	Substrate 661

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2578

PubMed

Title	Date	PubMed
CSF glutamate/GABA concentrations in pyridoxine-dependent seizures: etiology of pyridoxine-dependent seizures and the mechanisms of pyridoxine action in seizure control.	2001 Mar	11226725
Immunohistochemical studies of brain pyridoxine-5'-phosphate oxidase.	2002 Jan 25	11792364
Chronological changes in pyridoxine-5'-phosphate oxidase immunoreactivity in the seizure-sensitive gerbil hippocampus.	2002 Jun 15	12111839
Multistate binding in pyridoxine 5'-phosphate synthase: 1.96 A crystal structure in complex with 1-deoxy-D-xylulose phosphate.	2002 Oct 1	12269807
Vigabatrin inhibits pyridoxine-5'-phosphate oxidase, not pyridoxal kinase in the hippocampus of seizure prone gerbils.	2004 Feb	14568555
Structure of the phenazine biosynthesis enzyme PhzG.	2004 Nov	15502343
Dietary antioxidant lack, impaired hepatic glutathione reserve, and cholesterol gallstones.	2004 Nov	15469869
Purification and characterization of pyridoxine 5'-phosphate phosphatase from Sinorhizobium meliloti.	2005 Dec	16377884
[A preliminary proteomic analysis of tauopathies].	2005 May	16009011
Time course of changes in pyridoxal 5'-phosphate (vitamin B6 active form) and its neuroprotection in experimental ischemic damage.	2007 Jul	17531224
Vitamin B6 related epilepsy during childhood.	2007 Sep-Oct	18062169
Genome-based construction of the metabolic pathways of Orientia tsutsugamushi and comparative analysis within the Rickettsiales order.	2008	18528528
Identification of non-Alzheimer's disease tauopathies-related proteins by proteomic analysis.	2008 Jul	18647502
Pyridoxal phosphate-dependent neonatal epileptic encephalopathy.	2008 Mar	18296573
The assembly of the plasmodial PLP synthase complex follows a defined course.	2008 Mar 19	18350152
Potential role of pyridoxal-5'-phosphate phosphatase/chronopin in epilepsy.	2008 May	18346735
Human brain pyridoxal-5'-phosphate phosphatase (PLPP):protein transduction of PEP-1-PLPP into PC12 cells.	2008 May 31	18510874
Pyridoxal phosphate-dependent neonatal epileptic encephalopathy.	2009	21686393
Pyridoxine 5'-phosphate oxidase, not pyridoxal kinase, involves in long-term potentiation induction in the rat dentate gyrus.	2009 Jan	18680158
Enhanced pyridoxal 5'-phosphate synthetic enzyme immunoreactivities do not contribute to GABAergic inhibition in the rat hippocampus following pilocarpine-induced status epilepticus.	2009 Mar 31	19356691
Inherited glutathione reductase deficiency and Plasmodium falciparum malaria--a case study.	2009 Oct 6	19806191
Pyridoxine-dependent epilepsy and pyridoxine phosphate oxidase deficiency: unique clinical symptoms and non-specific EEG characteristics.	2010 Jul	20412262
Seizures and paroxysmal events: symptoms pointing to the diagnosis of pyridoxine-dependent epilepsy and pyridoxine phosphate oxidase deficiency.	2010 Jul	20370816
Proteomic analysis of aging brain in SAMP10 mouse: a model of age-related cerebral degeneration.	2010 Jun	20471994
A genomic perspective on the potential of Actinobacillus succinogenes for industrial succinate production.	2010 Nov 30	21118570

Patents

Sample Use Guides

In Vivo Use Guide

Single injection of 10 ug of pyridoxine-phosphate.

Route of Administration: Intravenous

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 19:45:28 UTC 2023` Edited by `admin` on `Fri Dec 15 19:45:28 UTC 2023`
Record UNII	RG20W8WYLS
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PYRIDOXINE PHOSPHATE

Common Name

English

VITAMIN B6 (PYRIDOXINE PHOSPHATE)

Common Name

English

NSC-83119

Code

English

Pyridoxine phosphate [WHO-DD]

Common Name

English

PYRIDOXINE 5-PHOSPHATE

Common Name

English

3,4-PYRIDINEDIMETHANOL, 5-HYDROXY-6-METHYL-, .ALPHA.3-(DIHYDROGEN PHOSPHATE)

Systematic Name

English

Code System Code Type Description

FDA UNII

RG20W8WYLS