U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 671 - 680 of 2596 results

Status:
Other

Class (Stereo):
CHEMICAL (EPIMERIC)

Conditions:

There is no information related the biological and pharmacological application of cefdinir lactone but it’s known that this compound is an admixture of cefdinir, that is why it’s also called as cefdinir impurity E.
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Ferric formate - the inorganic compound, a salt of iron and formic acid with the formula Fe (CHO 2)3. It is used in preservation of silage. Mineral product (a source of iron) suitable for use in an animal feed or feed supplement or other veterinary use.
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)

Conditions:

Fumitremorgin A (FTA) is the most potent mycotoxin among fumitremorgins, a series of tremorgenic toxins isolated from Aspergillus fumigatus by Yamazaki et al. in 1971. When injected intravenously in experimental animals, FTA causes tremor and generalized tonic-clonic convulsion. Both dopaminergic and gamma-aminobutyric acid (GABA)-ergic systems are involved in FTA-induced abnormal behaviors. On the other hand insignificant participation of serotonergic mechanism in modulation of those behavioral states elicited by FTA is conclusively suggested.
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)

Conditions:

10-Deacetylbaccatin III is a natural taxoid, isolated from the leaves of the European yew tree, Taxus baccata. 10-Deacetylbaccatin III is a very useful starting material in the semisynthetic production of the anticancer drug taxol and analogs. The first chemical conversion of 10-deacetylbaccatin III into paclitaxel and 10-deacetylpaclitaxel was achieved through the hydroxyamination of the 13-cinnamoylbaccatin IIΙ derivatives. This strategy led also to the discovery of docetaxel. A more convenient procedure for a large scale production of paclitaxel and docetaxel, based on the direct coupling of O-protected baccatin III derivatives with the acid side chain of paclitaxel or docetaxel, made paclitaxel as well as docetaxel available for clinical use.
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

There is no information about medical and biological application of ferrous thiocyanate, which is known as rhodanide (red color of the complex).
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)

Conditions:

Betamethasone 9,11-epoxide (aka betamethasone impurity E) is an impurity of the preparation of Betamethasone. Betamethasone and several derivatives are approved for the treatment of various disorders where the use of corticosteroids is indicated.
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)


Conditions:

Stylopine is a major component of the leaf of Chelidonium majus L. (Papaveraceae) which has been used for the removal of warts, papillomas, and condylomas, as well as the treatment of liver disease in oriental countries. It was shown that stylopine might contribute to the anti-inflammatory activity of Chelidonium majus by means of suppressing NO and PGE2 production. Stylopine has also been highlighted as a model compound for the design and future development of structurally related AKR1C3 inhibitors.
Status:
Other

Class (Stereo):
CHEMICAL (RACEMIC)

Conditions:

Trans-abacavir is the trans-isomer of abacavir, considered to be abacavir USP impurity. Abacavir, a nucleoside analog, is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection.
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

N-(3-Acetyl-4-hydroxyphenyl)butanamide is a key intermediate for the synthesis of β1-selective blocker acebutolol.
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)

Conditions:

Polycyclic aromatic hydrocarbon.