| Stereochemistry | ABSOLUTE |
| Molecular Formula | C19H17NO4 |
| Molecular Weight | 323.3426 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
C1OC2=CC=C3C[C@H]4N(CCC5=CC6=C(OCO6)C=C45)CC3=C2O1
InChI
InChIKey=UXYJCYXWJGAKQY-OAHLLOKOSA-N
InChI=1S/C19H17NO4/c1-2-16-19(24-10-21-16)14-8-20-4-3-12-6-17-18(23-9-22-17)7-13(12)15(20)5-11(1)14/h1-2,6-7,15H,3-5,8-10H2/t15-/m1/s1
Stylopine is a major component of the leaf of Chelidonium majus L. (Papaveraceae) which has been used for the removal of warts, papillomas, and condylomas, as well as the treatment of liver disease in oriental countries. It was shown that stylopine might contribute to the anti-inflammatory activity of Chelidonium majus by means of suppressing NO and PGE2 production. Stylopine has also been highlighted as a model compound for the design and future development of structurally related AKR1C3 inhibitors.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
PubMed
Patents
Sample Use Guides
Different doses of aerial parts of F. capreolata (AFC) (25, 50 and 100mg/kg) were assayed in the DNBS model of experimental colitis in mice, and the colonic damage was evaluated both histologically and biochemically. AFC containS 1.3% of stylopine and 0.9% of protopine
Route of Administration:
Oral
SUBSTANCE RECORD
