| Stereochemistry | ABSOLUTE |
| Molecular Formula | C32H41N3O7 |
| Molecular Weight | 579.6838 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12CCCN1C(=O)[C@]3(O)[C@@H](OCC=C(C)C)C4=C5N([C@H](OOC(C)(C)C[C@]5([H])N3C2=O)C=C(C)C)C6=CC(OC)=CC=C46
InChI
InChIKey=ACGHJVZDNQZJOV-BMOJZYMJSA-N
InChI=1S/C32H41N3O7/c1-18(2)12-14-40-28-26-21-11-10-20(39-7)16-23(21)34-25(15-19(3)4)41-42-31(5,6)17-24(27(26)34)35-29(36)22-9-8-13-33(22)30(37)32(28,35)38/h10-12,15-16,22,24-25,28,38H,8-9,13-14,17H2,1-7H3/t22-,24-,25+,28-,32+/m0/s1
| Molecular Formula | C32H41N3O7 |
| Molecular Weight | 579.6838 |
| Charge | 0 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Fumitremorgin A (FTA) is the most potent mycotoxin among fumitremorgins, a series of tremorgenic toxins isolated from Aspergillus fumigatus by Yamazaki et al. in 1971. When injected intravenously in experimental animals, FTA causes tremor and generalized tonic-clonic convulsion. Both dopaminergic and gamma-aminobutyric acid (GABA)-ergic systems are involved in FTA-induced abnormal behaviors. On the other hand insignificant participation of serotonergic mechanism in modulation of those behavioral states elicited by FTA is conclusively suggested.
CNS Activity
Originator
Approval Year
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|