U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 631 - 640 of 2596 results

Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)

Conditions:

Dibutyl tartrate is a plasticizer listed as an ingredient in pharmaceutical formulations.
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)

Conditions:

Lycorine, galantamine and tazettine has been found as one of the major alkaloid from Amaryllidaceae plants. Tazettine showed affinity to the serotonin reuptake transport protein.
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)


Conditions:

Catalposide is a compound isolated from irinoid-producing plant Catalpa ovata. Catalposide has been shown to possess anti-microbial, anti-tumoral, and anti-inflammatory properties. was found to inhibit the productions of tumor necrosis factor-alpha (TNF- alpha), interleukin-1beta, and interleukin-6 (IL-6), and the activation of nuclear factor kB (NF-kB) in RAW 264.7 macrophages activated with lipopolysaccharide (LPS).
Status:
Other

Class (Stereo):
CHEMICAL (RACEMIC)


Conditions:

Adrenoglomerulotropin is a lipid factor obtained from pineal extracts, selectively stimulates secretion of aldosterone.
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)


Conditions:

7α-hydroxytestosterone is an androstanoid that is testosterone substituted by a α-hydroxy group at position 7. It is a polar testosterone metabolite first identified by incubation of testes of adult rats with testosterone. Cytochrome P450 2A1 (CYP2A1) present in rat testis catalyzes the metabolism of testosterone into 7α-hydroxytestosterone. 7α-hydroxytestosterone is also a natural product found in Daphnia magna exposed to the biocide tributyltin. It has been reported to inhibit steroidogenic enzymes in testis including 5α-reductase and 3α-hydroxysteroid dehydrogenase (17β-HSD3). In the developing rat testis and Leydig cells 7 alpha-hydroxytestosterone effected the activity of 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1), enzyme that interconverts active corticosterone and inactive 11-dehydrocorticosterone. It competitively suppressed 11 beta-HSD1 oxidase and reductase activities in rat testis microsome preparations and regulated the direction of 11 beta-HSD1 activity in rat Leydig cells. 7-hydroxytestosterone does not influence rat seminal vesicle weight nor does it induce thermogenic enzymes. It was reported that 7a-hydroxytestosterone has no androgenic activity as measured by its lack of effect on maintenance of acid phosphatase in the prostate of castrated rats.
(+)-3-(3-Hydroxyphenyl)-N-(1-propyl)piperidine ((+)-3-PPP or preclamor, (R)) is an agonist of the sigma receptors and also acts as a dopamine receptor agonist with autoreceptor as well as postsynaptic receptor stimulatory properties. In vivo experiments have shown, that preclamor, (R) inhibited DOPA accumulation in the striatum, nucleus accumbens, and medial prefrontal cortex.
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)

Conditions:

(-)-Usnic acid is the 'S-' isomer of usnic acid a bioactive compound mainly found as a secondary metabolite in lichens. Meaningful differences have been noted in the bioactivity of (+)- and (-)- usnic acid. For Example (-)-usnic acid is more active as an antiviral against H1N1 influenza; but, derivitization reverses this specificity (-)usnic acid is also a selective natural herbicide because of its blocking action against a specific key plant enzyme. In contrast (+)-usnic acid showed higher cytotoxic activity in cancerous cells, and (+)-usnic acid appears to be selective against Streptococcus mutants without perturbing side effects on the oral saprophyte flora.
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)


Conditions:

Ryanodine (or ryania), a natural product found in members of the genusRyania and was previously used in insecticides. Its properties and biological actions have permitted the identification and molecular characterization of a family of intracellular Ca2+ release channels, now commonly termed the ryanodine receptors. Ryanodine binds with high affinity to the ryanodine receptors to modulate intracellular Ca2+ release, depending on the concentration used
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)

Conditions:

(2R,3AR,6AR)-1-((2S)-2-(((1S)-1-(ethoxycarbonyl)-3-phenylpropyl)amino)propanoyl)octahydrocyclopenta(B)pyrole-2-carboxylic acid is one of many isomers of ramipril and is known as Impurity N. Ramipril is an angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure (hypertension) and congestive heart failure.
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

There is no information about biological and pharmacological application of nickel benzoate.