Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C14H21NO |
| Molecular Weight | 219.3226 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCN1CCC[C@@H](C1)C2=CC(O)=CC=C2
InChI
InChIKey=HTSNFXAICLXZMA-ZDUSSCGKSA-N
InChI=1S/C14H21NO/c1-2-8-15-9-4-6-13(11-15)12-5-3-7-14(16)10-12/h3,5,7,10,13,16H,2,4,6,8-9,11H2,1H3/t13-/m0/s1
| Molecular Formula | C14H21NO |
| Molecular Weight | 219.3226 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
(+)-3-(3-Hydroxyphenyl)-N-(1-propyl)piperidine ((+)-3-PPP or preclamor, (R)) is an agonist of the sigma receptors and also acts as a dopamine receptor agonist with autoreceptor as well as postsynaptic receptor stimulatory properties. In vivo experiments have shown, that preclamor, (R) inhibited DOPA accumulation in the striatum, nucleus accumbens, and medial prefrontal cortex.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: Q99720|||Q7Z653 Gene ID: 10280.0 Gene Symbol: SIGMAR1 Target Organism: Homo sapiens (Human) |
|||
Target ID: Q5BJF2 Gene ID: 27346.0 Gene Symbol: TMEM97 Target Organism: Homo sapiens (Human) |
|||
Target ID: P14416 Gene ID: 1813.0 Gene Symbol: DRD2 Target Organism: Homo sapiens (Human) |
|||
Target ID: Q99720|||Q7Z653 Gene ID: 10280.0 Gene Symbol: SIGMAR1 Target Organism: Homo sapiens (Human) |
|||
Target ID: P14416 Gene ID: 1813.0 Gene Symbol: DRD2 Target Organism: Homo sapiens (Human) |
|||
Target ID: Q5BJF2 Gene ID: 27346.0 Gene Symbol: TMEM97 Target Organism: Homo sapiens (Human) |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
PubMed
| Title | Date | PubMed |
|---|---|---|
| Differential agonist profile of the enantiomers of 3-PPP at striatal dopamine autoreceptors: dependence on extracellular dopamine. | 1991 Jul |
|
| Pharmacological characteristics of hyperambulation induced by the sigma ligand (+)-3-PPP in rats. | 1994 May |
|
| Involvement of direct inhibition of NMDA receptors in the effects of sigma-receptor ligands on glutamate neurotoxicity in vitro. | 2000 Sep 15 |
Sample Use Guides
in rats: at doses above 3 mg/kg (s.c.) increased the ambulatory activity of rats
Route of Administration:
Other
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:06:56 GMT 2023
by
admin
on
Sat Dec 16 08:06:56 GMT 2023
|
| Record UNII |
8L7H229K4I
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
8L7H229K4I
Created by
admin on Sat Dec 16 08:06:56 GMT 2023 , Edited by admin on Sat Dec 16 08:06:56 GMT 2023
|
PRIMARY | |||
|
85976-54-1
Created by
admin on Sat Dec 16 08:06:56 GMT 2023 , Edited by admin on Sat Dec 16 08:06:56 GMT 2023
|
PRIMARY | |||
|
DTXSID101017364
Created by
admin on Sat Dec 16 08:06:56 GMT 2023 , Edited by admin on Sat Dec 16 08:06:56 GMT 2023
|
PRIMARY | |||
|
202478
Created by
admin on Sat Dec 16 08:06:56 GMT 2023 , Edited by admin on Sat Dec 16 08:06:56 GMT 2023
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
RACEMATE -> ENANTIOMER |
|
||
|
|
SALT/SOLVATE -> PARENT |
