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Details

Stereochemistry ABSOLUTE
Molecular Formula C25H35NO9
Molecular Weight 493.5467
Optical Activity UNSPECIFIED
Defined Stereocenters 11 / 11
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of RYANIA

SMILES

CC(C)[C@@]1(O)[C@@H](OC(=O)C2=CC=CN2)[C@@]3(O)[C@@]4(C)C[C@]5(O)O[C@@]6([C@H](O)[C@@H](C)CC[C@]46O)[C@@]3(O)[C@]15C

InChI

InChIKey=JJSYXNQGLHBRRK-YSOSZROBSA-N
InChI=1S/C25H35NO9/c1-12(2)22(31)17(34-16(28)14-7-6-10-26-14)23(32)18(4)11-21(30)19(22,5)25(23,33)24(35-21)15(27)13(3)8-9-20(18,24)29/h6-7,10,12-13,15,17,26-27,29-33H,8-9,11H2,1-5H3/t13-,15+,17+,18-,19-,20-,21-,22+,23+,24+,25+/m0/s1

HIDE SMILES / InChI
Molecular Formula C25H35NO9
Molecular Weight 493.5467
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 11 / 11
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Ryanodine (or ryania), a natural product found in members of the genusRyania and was previously used in insecticides. Its properties and biological actions have permitted the identification and molecular characterization of a family of intracellular Ca2+ release channels, now commonly termed the ryanodine receptors. Ryanodine binds with high affinity to the ryanodine receptors to modulate intracellular Ca2+ release, depending on the concentration used

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Ryanodine receptor 1
4
Target ID: P21817
Gene ID: 6261.0
Gene Symbol: RYR1
Target Organism: Homo sapiens (Human)
Binding Agent
1064
 11.3 nM [Kd]
Ryanodine receptor 2
1
Target ID: Q92736
Gene ID: 6262.0
Gene Symbol: RYR2
Target Organism: Homo sapiens (Human)
Binding Agent
1064
Ryanodine receptor 3
1
Target ID: Q15413
Gene ID: 6263.0
Gene Symbol: RYR3
Target Organism: Homo sapiens (Human)
Binding Agent
1064
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
PubMed

PubMed

TitleDatePubMed
Effect of sulphur mustard on the expression of urokinase in cultured 3T3 fibroblasts.
1997
Calcium transients regulate titin organization during myofibrillogenesis.
2005 Mar
Lysosome-dependent Ca(2+) release response to Fas activation in coronary arterial myocytes through NAADP: evidence from CD38 gene knockouts.
2010 May
Para- and ortho-substitutions are key determinants of polybrominated diphenyl ether activity toward ryanodine receptors and neurotoxicity.
2011 Apr

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Kinetic and equilibrium measurements of [3H]ryanodine (ryania) binding to the Ca2+ release channel of rabbit skeletal and rat cardiac sarcoplasmic reticulum (SR) are examined to ascertain the nature of cooperative interactions among high and low affinity binding sites and to quantitate their distribution. Equilibrium studies reveal affinities of 1-4 nM for the highest affinity binding site and of 30-50 nM, 500-800 nM, and 2-4 microM for the lower affinity sites in both preparations, with Hill coefficients of significantly less than 1, and initial rates of association and dissociation increase with increasing concentrations of ryanodine.
Substance Class Chemical
Created
by admin
on Sat Dec 16 08:05:33 GMT 2023
Edited
by admin
on Sat Dec 16 08:05:33 GMT 2023
Record UNII
37H6ATE4SA
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
RYANIA
ISO  
Common Name English
(+)-RYANODINE
Brand Name English
RYANODINE [MI]
Common Name English
RYANIA [ISO]
Common Name English
1H-PYRROLE-2-CARBOXYLIC ACID, (3S,4R,4AR,6S,6AS,7S,8R,8AS,8BR,9S,9AS)-DODECAHYDRO-4,6,7,8A,8B,9A-HEXAHYDROXY-3,6A,9-TRIMETHYL-7-(1-METHYLETHYL)-6,9-METHANOBENZO(1,2)PENTALENO(1,6-BC)FURAN-8-YL ESTER
Systematic Name English
NSC-114572
Code English
RYANEX
Brand Name English
RYANICIDE
Brand Name English
RYANODIN
Brand Name English
Classification Tree Code System Code
EPA PESTICIDE CODE 71502
Created by admin on Sat Dec 16 08:05:33 GMT 2023 , Edited by admin on Sat Dec 16 08:05:33 GMT 2023
Code System Code Type Description
CAS
8047-13-0
Created by admin on Sat Dec 16 08:05:33 GMT 2023 , Edited by admin on Sat Dec 16 08:05:33 GMT 2023
SUPERSEDED
CAS
15662-33-6
Created by admin on Sat Dec 16 08:05:33 GMT 2023 , Edited by admin on Sat Dec 16 08:05:33 GMT 2023
PRIMARY
MERCK INDEX
m9712
Created by admin on Sat Dec 16 08:05:33 GMT 2023 , Edited by admin on Sat Dec 16 08:05:33 GMT 2023
PRIMARY Merck Index
WIKIPEDIA
Ryanodine
Created by admin on Sat Dec 16 08:05:33 GMT 2023 , Edited by admin on Sat Dec 16 08:05:33 GMT 2023
PRIMARY
NSC
114572
Created by admin on Sat Dec 16 08:05:33 GMT 2023 , Edited by admin on Sat Dec 16 08:05:33 GMT 2023
PRIMARY
PUBCHEM
441753
Created by admin on Sat Dec 16 08:05:33 GMT 2023 , Edited by admin on Sat Dec 16 08:05:33 GMT 2023
PRIMARY
ALANWOOD
ryania
Created by admin on Sat Dec 16 08:05:33 GMT 2023 , Edited by admin on Sat Dec 16 08:05:33 GMT 2023
PRIMARY
FDA UNII
37H6ATE4SA
Created by admin on Sat Dec 16 08:05:33 GMT 2023 , Edited by admin on Sat Dec 16 08:05:33 GMT 2023
PRIMARY
ECHA (EC/EINECS)
239-732-2
Created by admin on Sat Dec 16 08:05:33 GMT 2023 , Edited by admin on Sat Dec 16 08:05:33 GMT 2023
PRIMARY
EPA CompTox
DTXSID0032574
Created by admin on Sat Dec 16 08:05:33 GMT 2023 , Edited by admin on Sat Dec 16 08:05:33 GMT 2023
PRIMARY
CHEBI
8925
Created by admin on Sat Dec 16 08:05:33 GMT 2023 , Edited by admin on Sat Dec 16 08:05:33 GMT 2023
PRIMARY
NIH
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