U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 471 - 480 of 2596 results

Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)


Conditions:

Glyceryl 1-phosphate,(S)- or glycerol-1-phosphate is a glycerophosphate backbone of the archeal ether lipids. It results from the reduction of dihydroxyacetone phosphate using NADH (or NADPH) and divalent ions as cofactors. Two different enzymes carry out the condensation of the isoprenoid chains to the glycerophosphate backbone in archea. The first ether linkage that brings together glycerol-1-phosphate and geranylgeranyl diphosphate is catalyzed by a cytoplasmic protein geranylgeranylglyceryl diphosphate (GGGP) synthase.
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)


Conditions:

Praziquantel, (+)- is the dextrorotated (+) isomer of Praziquantel. Praziquantel (PZQ) is the drug of choice against schistosomiasis. Since exposure of schistosomes to the drug is associated with calcium influx and muscular contraction, calcium channels have been suggested as the target. It is a specific pharmacological effect seen exclusively with the active levo-R(-)stereo isomer of the drug. Praziquantel, (+)- apparently contributes little to the therapeutic efficacy of Praziquantel. In vivo, single 400-mg/kg oral doses of Praziquantel, (-)- and Praziquantel, (+)- achieved worm burden reductions of 100 and 19%, respectively. Moreover, worms treated in vivo with Praziquantel, (+)- displayed an only transient hepatic shift and returned to the mesenteric veins within 24 h.
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Cupric octanoate is a fungicide and bactericide used to control many plant diseases. Cupric octanoate is classified as category III (caution) for acute oral, dermal and inhalation toxicity and category IV for eye and skin irritation.
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)


Conditions:

D-isoleucine (D-Ile) can be assayed using chiral chromatography to differentiate the activities of D- and L-isoleucine in processes such as the induction of pigmentation in B16F0 melanoma cells and also to help characterize and differentiate various D-amino acid oxidases.
Status:
Other

Class (Stereo):
CHEMICAL (RACEMIC)

Conditions:

Pelletierine +/- also known as isopelletierine is an alkaloid found in the root-bark of the pomegranate tree. There is a little information about the pharmacological application of this compound, but one article describes its anthelminthic activity.
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)

Conditions:

(-)-Coniine is a biologically active enantiomer of piperidine alkaloid and nicotinic acetylcholine receptor agonist found in poison hemlock (Conium maculatum L.). (-)-Coniine is teratogenic and its teratogenecity can be explained by the binding, activation, and prolonged desensitization of fetal muscle-type nAChR, which results in the complete inhibition of fetal movement.
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)

Conditions:

Lyxose, an analog of riboflavin, isolated from human myocardium.
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

POTASSIUM TRIIODOZINCATE (KZnI3) is an inorganic compound complex iodide, potassium and zinc with formula KZnI 3 crystals is dissolved in water, it forms crystalline hydrates. Highly soluble in water. Molar mass of KZnI3 is 485.1917 g/mol,
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

There is no information about properties of trolamine salicylate monoester (also known as 2-(Bis(2-hydroxyethyl)amino)ethyl salicylate), except that this chemical substance is an ingredient of sunscreen.
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

NJ-5207787 is a potent and selective pharmacological tool available to establish the potential role of central and peripheral Y(2) receptors in vivo.