Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C8H17N |
Molecular Weight | 127.2273 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCC[C@@H]1CCCCN1
InChI
InChIKey=NDNUANOUGZGEPO-MRVPVSSYSA-N
InChI=1S/C8H17N/c1-2-5-8-6-3-4-7-9-8/h8-9H,2-7H2,1H3/t8-/m1/s1
Molecular Formula | C8H17N |
Molecular Weight | 127.2273 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/23086230
Sources: https://www.ncbi.nlm.nih.gov/pubmed/23086230
(-)-Coniine is a biologically active enantiomer of piperidine alkaloid and nicotinic acetylcholine receptor agonist found in poison hemlock (Conium maculatum L.). (-)-Coniine is teratogenic and its teratogenecity can be explained by the binding, activation, and prolonged desensitization of fetal muscle-type nAChR, which results in the complete inhibition of fetal movement.
CNS Activity
Approval Year
Sample Use Guides
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/23086230
Human rhabdomyosarcoma cell line TE-671 was incubated with (-)-Coniine at concentrations from 10(-8) M to 10(-3) M. (-)-Coniine was effective at eliciting changes in membrane potential sensing dye fluorescence, with the EC50 value of 65 uM.
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 09:09:36 UTC 2023
by
admin
on
Sat Dec 16 09:09:36 UTC 2023
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Record UNII |
QKK1SI92BR
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Record Status |
Validated (UNII)
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Record Version |
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-
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638021
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QKK1SI92BR
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DTXSID301019378
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admin on Sat Dec 16 09:09:36 UTC 2023 , Edited by admin on Sat Dec 16 09:09:36 UTC 2023
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