JNJ-5207787

Details

Stereochemistry	ACHIRAL
Molecular Formula	C32H38N4O2
Molecular Weight	510.6697
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(=O)N1CCC2=C1C=C(C=C2)N(C3CCN(CCC4CCCC4)CC3)C(=O)\C=C\C5=CC=CC(=C5)C#N

InChI

InChIKey=DSEJCLDJIFTPPH-FMIVXFBMSA-N

InChI=1S/C32H38N4O2/c1-24(37)35-20-14-28-10-11-30(22-31(28)35)36(32(38)12-9-26-7-4-8-27(21-26)23-33)29-15-18-34(19-16-29)17-13-25-5-2-3-6-25/h4,7-12,21-22,25,29H,2-3,5-6,13-20H2,1H3/b12-9+

HIDE SMILES / InChI

Molecular Formula	C32H38N4O2
Molecular Weight	510.6697
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14617685

NJ-5207787 is a potent and selective pharmacological tool available to establish the potential role of central and peripheral Y(2) receptors in vivo.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Neuropeptide Y receptor type 2 4 Target ID: CHEMBL4018 Sources: https://www.ncbi.nlm.nih.gov/pubmed/14617685	Antagonist 2849		7.0 null [pIC50]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2596

PubMed

Title	Date	PubMed
Ligands of the neuropeptide Y Y2 receptor.	2014-01-15	24365162
Characterization of N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyano-phenyl)-N-[1-(2-cyclopentyl-ethyl)-piperidin-4yl]acrylamide (JNJ-5207787), a small molecule antagonist of the neuropeptide Y Y2 receptor.	2004-03	14617685

Patents

Sample Use Guides

In Vivo Use Guide

JNJ-5207787 was intraperitoneally (i.p.) bioavailable (33%), but not orally, with a plasma half-life of 2.03 h. JNJ-5207787 given i.p. (30 mg/kg, rats)

Route of Administration: Intraperitoneal

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 22:29:48 GMT 2025` Edited by `admin` on `Mon Mar 31 22:29:48 GMT 2025`
Record UNII	OW44B6FA0Y
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

JNJ-5207787

Common Name

English

2-PROPENAMIDE, N-(1-ACETYL-2,3-DIHYDRO-1H-INDOL-6-YL)-3-(3-CYANOPHENYL)-N-(1-(2-CYCLOPENTYLETHYL)-4-PIPERIDINYL)-, (2E)-

Preferred Name

English

TRANS-N-(1-ACETYL-2,3-DIHYDRO-1H-INDOL-6-YL)-3-(3-CYANOPHENYL)-N-(1-(2-CYCLOPENTYLETHYL)PIPERIDIN-4-YL)ACRYLAMIDE

Systematic Name

English

Code System Code Type Description

PUBCHEM

10324083