N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indazole-3-carboxamide [ADB-FUBINACA] is a synthetic cannabinoid, a Schedule I drug. ADB-FUBINACA acts as a high potency agonist of cannabinoid CB1 receptor. The compound considered to be a component of illicit smoking mixtures "spice".

2-Cyano-4'-methylbiphenyl is a building block of the angiotensin II inhibitors for the treatment of hypertension known as the ‘Sartan’ family, like Irbesartan and it is an intermediate in the synthesis of glycogen synthase kinase-3 inhibitors with a selective sting for glycogen synthase kinase 3 alpha. 2-Cyano-4'-methylbiphenyl is a starting compound for the synthesis of substituted biphenyl tetrazole compounds with antimicrobial activity.

JWH-072 is a cannabinoid-2 receptor (CB-2) agonist. The physiological and toxicological properties of this compound are not known, but it was detected in initial blood, urine, and CSF samples from 18-year-old man presented to the emergency department (ED) with acute onset psychosis after allegedly smoking "spice." JWH-072 is intended for research and forensic purposes.

3',5'-DICHLORO-2-HYDROXY-2-METHYLBUT-3-ENANILIDE is a metabolite of vinclozolin, a dicarboximide fungicide widely used in the United States and Europe for control of diseases caused by B. cineera, S. sclerotiorum, and Monilinia species in fruits, grapes, ornamental plants, turfgrass and vegetables. This fungicide possesses antiandrogenic activity. 3',5'-DICHLORO-2-HYDROXY-2-METHYLBUT-3-ENANILIDE has an antiandrogenic activity too. Moreover, it is an antagonist of progesterone, glucocorticoid, mineralocorticoid receptors and agonist for both estrogen receptors. This ability to act via more than one mechanism must be taken into consideration in the risk assessment process.

(-)-p-Bromotetramisole is an inhibitor of non-specific alkaline phosphatase. L-p-Bromotetramisole shows no inhibition of specific phosphatase activity, and the D-enantiomer shows no inhibitory effects against either phosphatase. L-p-Bromotetramisole is used as a tool inhibitor in studies of tissue distribution of alkaline phosphatases.

Meleagrin is an indole alkaloids, extracted from Penicillium chrysogenum mycelia, is a bacterial enoyl-acyl carrier protein reductase (FabI) inhibitor, and has at least has one additional mode of action that could have potential for treating multidrug-resistant bacteria. Also was shown, that this alkaloid is useful for the control of c-Met-dependent metastatic and invasive breast malignancies.

Orteronel R form or also known as TAK-700 R-form is a naphthylmethylimidazole derivative.

The DOTAP (N-[1-(2,3-Dioleoyloxy)propyl]-N,N,N-trimethylammonium methyl-sulfate) is a liposomal transfection reagent suitable for transient and stable transfection of mammalian cell lines with DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides). Mixing DOTAP with DNA results in spontaneously formed stable complexes. These complexes can be added directly to the tissue culture medium. This method avoiding the cytotoxic effects commonly encountered with lipofection or others transfection methods. The recently published article described the ability of R-DOTAP stabilized microparticles (MP) to act as a carrier platform for antigens e.g. for cancer vaccination. It was investigated whether or not a combination of R-DOTAP and PLGA leads to a boosted adjuvant effect in dendritic cell maturation.

CCT129202 is a representative of a structurally novel series of imidazopyridine small-molecule ATP-competitive pan-Aurora inhibitors. This compound showed high selectivity for the Aurora kinases over a panel of other kinases tested and inhibits proliferation in multiple cultured human tumor cell lines. CCT129202 causes the accumulation of human tumor cells with >=4N DNA content, leading to apoptosis. CCT120202-treated human tumor cells showed a delay in mitosis, abrogation of nocodazole-induced mitotic arrest, and spindle defects. Growth of HCT116 xenografts in nude mice was inhibited after i.p. administration of CCT129202. The cyclin-dependent kinase inhibitor p21, is induced by CCT129202. Up-regulation of p21 by CCT129202 in HCT116 cells led to Rb hypophosphorylation and E2F inhibition, contributing to a decrease in thymidine kinase 1 transcription.

Behenamide MEA (behenoyl monoethanolamide) is the ethanolamide of behenic acid, which is used as a surfactant, and foaming agent in the cosmetic industry.