Asiaticoside B (TERMINOLOSIDE) was isolated from the roots of Cimicifuga foetida and roots/rhizomes extract of Actaea asiatica. It was found, that asiaticoside B had notable cytotoxicity against HepG2 and MCF-7 cancer cell lines.

3-Methylcholanthrene a compound, which can activate both aryl hydrocarbon receptor (AhR) and estrogen receptor alpha. It is used to induce fibrosarcomas and skin carcinomas in laboratory animals. The daily exposure to 3-methylcholanthrene induced changes in both gene expression and epigenomic remodeling, which had led to premature ovarian failure.

trans-Ketoconazole was identified as impurity of an antifungal compound cis-ketoconazole. Cis-Ketoconazole displayed broad-spectrum in vivo activity in a wide range of experimental fungal infections caused by different fungi in a variety of animal models. trans-isomer of ketoconazole is less active than cis-ketoconazole.

Information related to the biological or to the pharmacological activity of temazepam acetate is absent.

cimiracemoside N is a triterpene glycoside which can be isolated from the roots of Cimicifuga racemosa (Black Cohosh). Black Cohosh is consumed as a natural dietary supplement for the treatment of menopause symptoms.

Bromadiolone is a multi-feed, synthetic, second-generation anti-coagulant rodenticide. The active ingredient is formulated on a food base, typically cereal, to produce a ready to use bait containing 0.005% w/w bromadiolone. When compared to other anticoagulant rodenticides, bromadiolone has a good level of activity against the brown rat, and moderate levels of activity against mice. Bromadiolone is marginally more toxic to non-target 'farmyard' species than difenacoum. Bromadiolone is a potent poison to all mammal species and it is essential that all baits should be well protected from non-target animals. The best way to achieve this is by placing the baits in an approved bait box. Bromadiolone is a second-generation single-dose anticoagulant rodenticide. It disrupts the normal blood clotting mechanisms resulting in increased bleeding tendency and, eventually, profuse haemorrhage and death. Effectiveness of bromadiolone depends on exposure (i.e. consumption of the bait by the target organism).

Ondansetron 8-sulfate is a metabolite of the ondansetron, a drug which is used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, or surgery. Ondansetron is extensively metabolized in humans; the primary metabolic pathway is hydroxylation on the indole ring followed by glucuronide or sulfate conjugation.

6-alpha-Naloxol is active metabolite of naloxone. 6-alpha-Naloxol was shown to be neutral antagonist at the mu receptor in vitro, with no affect on cAMP levels or GTPitalic gammaS binding, regardless of morphine pretreatment. It elicits withdrawal behaviour and conditioned place aversion in morphine pretreated rodents.

R-(-)-modafinil acid is a major metabolite of armodafinil, a wakefulness-promoting agent for oral administration. It does not appear to contribute to the CNS-activating properties of the parent compound.

Modafinil acid is a metabolite of modafinil, a wake-promoting agent for oral administration. Orally administered modafinil is extensively biotransformed in the liver to the inactive metabolites modafinil acid and modafinil sulphone, before being eliminated primarily in the urine (elimination half-life 9 to 14 hours). Modafinil acid was the major urinary metabolite, which accounted for 35% to 60% of the dose. Two major metabolites of modafinil, modafinil acid, and modafinil sulfone, do not appear to contribute to the CNS-activating properties of modafinil.