Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C15H14O3S |
| Molecular Weight | 274.335 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)C[S+]([O-])C(C1=CC=CC=C1)C2=CC=CC=C2
InChI
InChIKey=QARQPIWTMBRJFX-UHFFFAOYSA-N
InChI=1S/C15H14O3S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H,16,17)
| Molecular Formula | C15H14O3S |
| Molecular Weight | 274.335 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Modafinil acid is a metabolite of modafinil, a wake-promoting agent for oral administration. Orally administered modafinil is extensively biotransformed in the liver to the inactive metabolites modafinil acid and modafinil sulphone, before being eliminated primarily in the urine (elimination half-life 9 to 14 hours). Modafinil acid was the major urinary metabolite, which accounted for 35% to 60% of the dose. Two major metabolites of modafinil, modafinil acid, and modafinil sulfone, do not appear to contribute to the CNS-activating properties of modafinil.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Single-dose pharmacokinetics of modafinil and methylphenidate given alone or in combination in healthy male volunteers. | 1998 Mar |
|
| A double-blind, placebo-controlled, ascending-dose evaluation of the pharmacokinetics and tolerability of modafinil tablets in healthy male volunteers. | 1999 Jan |
|
| Determination of modafinil, modafinil acid and modafinil sulfone in human plasma utilizing liquid-liquid extraction and high-performance liquid chromatography. | 2002 Feb 15 |
|
| Population pharmacokinetics of modafinil and its acid and sulfone metabolites in Chinese males. | 2011 Dec |
|
| Population pharmacokinetics of modafinil acid and estimation of the metabolic conversion of modafinil into modafinil acid in 5 major ethnic groups of China. | 2012 Nov |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 10:49:53 UTC 2023
by
admin
on
Sat Dec 16 10:49:53 UTC 2023
|
| Record UNII |
54N37HN7N4
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
DTXSID60979768
Created by
admin on Sat Dec 16 10:49:54 UTC 2023 , Edited by admin on Sat Dec 16 10:49:54 UTC 2023
|
PRIMARY | |||
|
63547-24-0
Created by
admin on Sat Dec 16 10:49:54 UTC 2023 , Edited by admin on Sat Dec 16 10:49:54 UTC 2023
|
PRIMARY | |||
|
3085267
Created by
admin on Sat Dec 16 10:49:54 UTC 2023 , Edited by admin on Sat Dec 16 10:49:54 UTC 2023
|
PRIMARY | |||
|
Modafinil acid
Created by
admin on Sat Dec 16 10:49:54 UTC 2023 , Edited by admin on Sat Dec 16 10:49:54 UTC 2023
|
PRIMARY | |||
|
54N37HN7N4
Created by
admin on Sat Dec 16 10:49:54 UTC 2023 , Edited by admin on Sat Dec 16 10:49:54 UTC 2023
|
PRIMARY | |||
|
1445346
Created by
admin on Sat Dec 16 10:49:54 UTC 2023 , Edited by admin on Sat Dec 16 10:49:54 UTC 2023
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
ENANTIOMER -> RACEMATE | |||
|
|
ENANTIOMER -> RACEMATE |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
PARENT -> METABOLITE |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
PARENT -> IMPURITY |
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
|
||
|
PARENT -> IMPURITY |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
|