Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C15H14O3S |
| Molecular Weight | 274.335 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)C[S+]([O-])C(C1=CC=CC=C1)C2=CC=CC=C2
InChI
InChIKey=QARQPIWTMBRJFX-UHFFFAOYSA-N
InChI=1S/C15H14O3S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H,16,17)
Modafinil acid is a metabolite of modafinil, a wake-promoting agent for oral administration. Orally administered modafinil is extensively biotransformed in the liver to the inactive metabolites modafinil acid and modafinil sulphone, before being eliminated primarily in the urine (elimination half-life 9 to 14 hours). Modafinil acid was the major urinary metabolite, which accounted for 35% to 60% of the dose. Two major metabolites of modafinil, modafinil acid, and modafinil sulfone, do not appear to contribute to the CNS-activating properties of modafinil.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Single-dose pharmacokinetics of modafinil and methylphenidate given alone or in combination in healthy male volunteers. | 1998 Mar |
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| A double-blind, placebo-controlled, ascending-dose evaluation of the pharmacokinetics and tolerability of modafinil tablets in healthy male volunteers. | 1999 Jan |
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| Determination of modafinil, modafinil acid and modafinil sulfone in human plasma utilizing liquid-liquid extraction and high-performance liquid chromatography. | 2002 Feb 15 |
|
| Population pharmacokinetics of modafinil and its acid and sulfone metabolites in Chinese males. | 2011 Dec |
|
| Population pharmacokinetics of modafinil acid and estimation of the metabolic conversion of modafinil into modafinil acid in 5 major ethnic groups of China. | 2012 Nov |
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DTXSID60979768
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63547-24-0
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3085267
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Modafinil acid
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54N37HN7N4
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1445346
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PARENT (METABOLITE)
SUBSTANCE RECORD
