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Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Pircotoxinin is a component of pircotoxin, a poisonous compound from Anamirta cocculus. It exerts its action by blockade of anion channels, such as GABA-A or GlyR.
Glycitein is an orally active flavonoid, which possesses estrogenic activity. It was discovered, that glycitein suppresses osteoclast generation and induces osteoclast apoptosis and exerts bone beneficial effects.
Tropic acid is a chiral substance, existing as either a racemic mixture or as a single enantiomer. TROPIC ACID, (-)- is also known as L-Tropic acid or (S)-Tropic acid. (S)-Tropic Acid is used as a reagent in the synthesis of Scopolamine and its salts.
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
N-(Fluorenyl-9-methoxycarbonyl)leucine (NPC 15199) is an organic compound that demonstrates antiinflammatory effects. NPC 15199 and other N-(9-fluorenylmethoxycarbonyl)-protected amino acids are demonstrated to block recruitment of neutrophils into inflammatory lesions and to inhibit T-cell activation in vitro, and are classified as leumedins. N-(Fluorenyl-9-methoxycarbonyl)leucine is described to act as a chemically distinct ligand and modulator of PPARγ (peroxisome proliferator-activated receptor γ). N-(Fluorenyl-9-methoxycarbonyl)leucine is demonstrated to increase intracellular Ca2+ and to mobilize Ca2+ stores in human bladder female transitional cancer (BFTC) cells.
DOXYLAMINE CHLOROTHEOPHYLLINATE is a combination of two drugs doxylamine and 8-chlorotheophylline. Doxylamine is a first-generation antihistamine, that have short-term sedative effect. 8-Chlorotheophylline, a chlorinated derivative of theophylline, was added in order to counteract drowsiness. Doxylamine Chlorotheophyllinate can be used to treat motion sickness and nausea.
1,3-Diiminobenz[f]isoindoline is an intermediate in the preparation of synthetic dyes.
There has been little to no formal interest in the biological and/or pharmacological application of 3-(4-Fluorobenzoyl)propyl chloride.
2-chloro-phenothiazine is an important intermediate in the synthesis of anti-psychotic, anesthetic, anticonvulsant and other pharmaceutical drugs. 2-chlorophenothiazine exerts no effect on cellular bioenergetics and do not inhibit glioblastoma cell proliferation. In the photo-micronucleus test using V79 cells, 2-chlorophenothiazine was identified as photogenotoxin.
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Dihydrocoumarin is a concentrated aromatic and flavor ingredient which may be used in flavor and fragrance
compounds according to legal and IFRA or FEMA GRAS/FDA guidelines. Dihydrocoumarin is a common compound found in sweet clover that has been studied as a disruptor of epigenetic processes in cells. Epigenetic processes control gene expression within a cell and are highly influenced by environmental factors. Epigenomic disruptions change which genes are expressed and to what extent and are not linked to DNA mutations. Dihydrocoumarin has been shown to inhibit the sirtuin deacetylase family, specifically Sir2, SIRT1, and SIRT2.
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Anthraquinone has yet to be found in nature. Of all the quinones found naturally, those derived from anthraquinone far exceed all others. Many of these are found in molds. Derivatives of 9,10-anthracenedione (anthraquinones) with several hydroxy and other functional groups are biologically active compounds isolated from Rubia and Cassia medical plant species. Anthraquinone is a comparatively safe compound: LD50 (rat) is 3500 mg/kg. It is a mild allergen and, as a fine powder, may cause skin irritation. Exposure to 3,000 ppm may be tolerated for only 30–60 min after which irritation of the nose, throat, and lungs may occur along with headaches, dizziness, and slurred speech. 9,10-anthraquinone is a weak carcinogen. Aside from its major use in the manufacture of intermediates for anthraquinone dyes and pigments, anthraquinone is finding increasing interest as a catalyst in the pulping of wood, in the polymerization of various materials for plastics, and in the isomerization of vegetable oils. It has been used to make seeds distasteful to birds (bird repellent) and as an accelerator in nickel electroplating.