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Details

Stereochemistry ACHIRAL
Molecular Formula C12H8ClNS
Molecular Weight 233.717
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of 2-CHLOROPHENOTHIAZINE

SMILES

ClC1=CC2=C(SC3=C(N2)C=CC=C3)C=C1

InChI

InChIKey=KFZGLJSYQXZIGP-UHFFFAOYSA-N
InChI=1S/C12H8ClNS/c13-8-5-6-12-10(7-8)14-9-3-1-2-4-11(9)15-12/h1-7,14H

HIDE SMILES / InChI

Description

2-chloro-phenothiazine is an important intermediate in the synthesis of anti-psychotic, anesthetic, anticonvulsant and other pharmaceutical drugs. 2-chlorophenothiazine exerts no effect on cellular bioenergetics and do not inhibit glioblastoma cell proliferation. In the photo-micronucleus test using V79 cells, 2-chlorophenothiazine was identified as photogenotoxin.

Approval Year

Unknown
139594
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
PubMed

PubMed

TitleDatePubMed
The application of the micronucleus test in Chinese hamster V79 cells to detect drug-induced photogenotoxicity.
1999 Sep 15
Prediction of genotoxicity of chemical compounds by statistical learning methods.
2005 Jun
Patents

Patents

04705854
1
20040053920
1
CN101417986A
1

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
At a 2-chlorophenothiazine (2Cl-PTH) concentration of 2 uM, an apparent 16-fold increase in Ks was observed for 6-methyl-benzo[a]pyrene (6-CH3-BaP). 2Cl-PTH might exert a strong effect on the metabolism of 6-CH3-BaP.
Name Type Language
2-CHLOROPHENOTHIAZINE
Systematic Name English
PHENOTHIAZINE, 2-CHLORO-
Systematic Name English
NSC-170953
Code English
2-CL-PH
Common Name English
2-CHLORO-10H-PHENOTHIAZINE
Systematic Name English
PROCHLORPERAZINE MALEATE IMPURITY D [EP IMPURITY]
Common Name English
CHLORPROMAZINE HYDROCHLORIDE IMPURITY E [EP IMPURITY]
Common Name English
NSC-67188
Code English
NSC-17469
Code English
2-CHLORO-PHENOTHIAZINE
Systematic Name English
Code System Code Type Description
PUBCHEM
7088
Created by admin on Fri Dec 15 15:33:27 GMT 2023 , Edited by admin on Fri Dec 15 15:33:27 GMT 2023
PRIMARY
CAS
92-39-7
Created by admin on Fri Dec 15 15:33:27 GMT 2023 , Edited by admin on Fri Dec 15 15:33:27 GMT 2023
PRIMARY
NSC
17469
Created by admin on Fri Dec 15 15:33:27 GMT 2023 , Edited by admin on Fri Dec 15 15:33:27 GMT 2023
PRIMARY
NSC
67188
Created by admin on Fri Dec 15 15:33:27 GMT 2023 , Edited by admin on Fri Dec 15 15:33:27 GMT 2023
PRIMARY
EPA CompTox
DTXSID3057854
Created by admin on Fri Dec 15 15:33:27 GMT 2023 , Edited by admin on Fri Dec 15 15:33:27 GMT 2023
PRIMARY
ECHA (EC/EINECS)
202-152-5
Created by admin on Fri Dec 15 15:33:27 GMT 2023 , Edited by admin on Fri Dec 15 15:33:27 GMT 2023
PRIMARY
NSC
170953
Created by admin on Fri Dec 15 15:33:27 GMT 2023 , Edited by admin on Fri Dec 15 15:33:27 GMT 2023
PRIMARY
FDA UNII
95H3AO2301
Created by admin on Fri Dec 15 15:33:27 GMT 2023 , Edited by admin on Fri Dec 15 15:33:27 GMT 2023
PRIMARY
PARENT (METABOLITE)
Structure of CHLORPROMAZINE
NIH
NCATS
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