Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C16H12O5 |
| Molecular Weight | 284.2635 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC2=C(OC=C(C2=O)C3=CC=C(O)C=C3)C=C1O
InChI
InChIKey=DXYUAIFZCFRPTH-UHFFFAOYSA-N
InChI=1S/C16H12O5/c1-20-15-6-11-14(7-13(15)18)21-8-12(16(11)19)9-2-4-10(17)5-3-9/h2-8,17-18H,1H3
| Molecular Formula | C16H12O5 |
| Molecular Weight | 284.2635 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| [Daily intake of isoflavones based on the market basket method]. | 2001 Apr |
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| Suppression effect of soy isoflavones on nitric oxide production in RAW 264.7 macrophages. | 2001 Apr |
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| Effect of polyphenols on calcium content and alkaline phosphatase activity in rat femoral tissues in vitro. | 2001 Dec |
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| Optimization of a yeast estrogen screen and its applicability to study the release of estrogenic isoflavones from a soygerm powder. | 2001 Jul |
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| Glycitein effect on suppressing the proliferation and stimulating the differentiation of osteoblastic MC3T3-E1 cells. | 2001 May |
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| Effects of phytoestrogens on acetylcholine- and isoprenaline-induced vasodilation in rat aorta. | 2001 Sep |
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| Quantification of isoflavones and lignans in serum using isotope dilution liquid chromatography/tandem mass spectrometry. | 2003 |
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| Determination of isoflavones in ready-to-feed soy-based infant formula. | 2003 Jan-Feb |
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| Stability and bioaccessibility of isoflavones from soy bread during in vitro digestion. | 2003 Jul 30 |
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| Effect of soy-derived isoflavones on hot flushes, endometrial thickness, and the pulsatility index of the uterine and cerebral arteries. | 2003 May |
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| The influence of dietary isoflavone on the uterotrophic response in juvenile rats. | 2003 Nov |
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| Dietary exposure estimates of isoflavones from the 1998 UK Total Diet Study. | 2004 Apr |
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| Influence of soya-based infant formula consumption on isoflavone and gut microflora metabolite concentrations in urine and on faecal microflora composition and metabolic activity in infants and children. | 2004 Apr |
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| Recombinant human estrogen, androgen and progesterone receptors for detection of potential endocrine disruptors. | 2004 Feb |
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| Simultaneous determination of isoflavones and bisphenol A in rat serum by high-performance liquid chromatography coupled with coulometric array detection. | 2004 Jan |
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| Evaluation of the preventive effect of isoflavone extract on bone loss in ovariectomized rats. | 2004 May |
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| LC/UV/ESI-MS analysis of isoflavones in Edamame and Tofu soybeans. | 2004 May 19 |
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| Effects of a diet rich in phytoestrogens on prostate-specific antigen and sex hormones in men diagnosed with prostate cancer. | 2004 Sep |
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| Analysis of isoflavone contents in vegetable soybeans. | 2004 Spring |
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| Daidzein-rich isoflavone-aglycones for menopausal symptoms. | 2005 Apr |
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| Soy isoflavone glycitein protects against beta amyloid-induced toxicity and oxidative stress in transgenic Caenorhabditis elegans. | 2005 Aug 25 |
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| Isoflavones modulate the glucuronidation of estradiol in human liver microsomes. | 2005 Dec |
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| Evaluation of isoflavone aglycon and glycoside distribution in soy plants and soybeans by fast column high-performance liquid chromatography coupled with a diode-array detector. | 2005 Jul 27 |
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| Bioavailability of isoflavone phytoestrogens in postmenopausal women consuming soya milk fermented with probiotic bifidobacteria. | 2005 Jun |
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| Pharmacokinetics of isoflavones, daidzein and genistein, after ingestion of soy beverage compared with soy extract capsules in postmenopausal Thai women. | 2005 Mar 3 |
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| Metabolism of glycitein (7,4'-dihydroxy-6-methoxy-isoflavone) by human gut microflora. | 2005 Nov 2 |
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| Prostatic fluid concentrations of isoflavonoids in soy consumers are sufficient to inhibit growth of benign and malignant prostatic epithelial cells in vitro. | 2006 Apr 1 |
|
| Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods. | 2006 Nov |
Sample Use Guides
dietary supplement containing high-dose purified soy isoflavones (genistein, 558 mg/day; daidzein, 296 mg/day; and glycitein, 44 mg/day) to 30 postmenopausal women for 84 days and collected peripheral lymphocytes at timed intervals
Route of Administration:
Oral
Bone marrow-derived osteoclasts were cultured with various concentrations (0.01-100 nM) of glycitein. Osteoclast generation was inhibited by glycitein in a biphasic-dose-dependent manner and showed the greatest inhibitory effects at 10 nM (-70%, p < 0.01). Glycitein increased caspase 3/7 activity by 15% at a concentration of 10 nM (p < 0.001). Further, 10 nM glycitein significantly decreased the expression of IL-6 (-53%, p < 0.05) and RANKL (-64%, p < 0.05) in osteoblasts but did not change mRNA levels of OPG.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:38:49 GMT 2023
by
admin
on
Fri Dec 15 15:38:49 GMT 2023
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| Record UNII |
92M5F28TVF
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| Record Status |
Validated (UNII)
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| Record Version |
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DSLD |
1428 (Number of products:4)
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DSLD |
3258 (Number of products:29)
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NCI_THESAURUS |
C599
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| Code System | Code | Type | Description | ||
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C086566
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1295844
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34778
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GLYCITEIN
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92M5F28TVF
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40957-83-3
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5317750
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C63949
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DTXSID40193960
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